Aliases for PHF2 Gene
Aliases for PHF2 Gene
External Ids for PHF2 Gene
- HGNC: 8920
- Entrez Gene: 5253
- Ensembl: ENSG00000197724
- OMIM: 604351
- UniProtKB: O75151
Previous GeneCards Identifiers for PHF2 Gene
- GC09U990060
- GC09P088066
- GC09P089638
- GC09P091680
- GC09P093418
- GC09P095378
- GC09P096338
- GC09P066069
Summaries for PHF2 Gene
-
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
GeneCards Summary for PHF2 Gene
PHF2 (PHD Finger Protein 2) is a Protein Coding gene. Diseases associated with PHF2 include Decubitus Ulcer. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and methylated histone binding. An important paralog of this gene is PHF8.
UniProtKB/Swiss-Prot for PHF2 Gene
-
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated Lys-9 of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated Lys-4 of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF2 Gene
Genomics for PHF2 Gene
GeneHancer (GH) Regulatory Elements for PHF2 Gene
Promoters and enhancers for PHF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PHF2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PHF2 Gene
Genomic Locations for PHF2 Gene
- chr9:93,576,407-93,679,587
- (GRCh38/hg38)
- Size:
- 103,181 bases
- Orientation:
- Plus strand
- chr9:96,338,689-96,441,869
- (GRCh37/hg19)
Genomic View for PHF2 Gene
Genes around PHF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.31 by Ensembl
- 9q22.31 by Entrez Gene
- 9q22.31 by HGNC
PHF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHF2 Gene
Proteins for PHF2 Gene
-
Protein details for PHF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75151-PHF2_HUMAN
- Recommended name:
- Lysine-specific demethylase PHF2
- Protein Accession:
- O75151
- Q4VXG0
- Q8N3K2
- Q9Y6N4
Protein attributes for PHF2 Gene
- Size:
- 1096 amino acids
- Molecular mass:
- 120775 Da
- Quaternary structure:
-
- Component of the PHF2-ARID5B complex, at least composed of PHF2 and ARID5B. Interacts with HNF4A and NR1H4.
- SequenceCaution:
-
- Sequence=BAA31637.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for PHF2 Gene
Post-translational modifications for PHF2 Gene
- Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex.
- Ubiquitination at Lys175, isoforms=412, and isoforms=427
Other Protein References for PHF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for PHF2 (PHF2)
- Novus Biologicals Antibodies for PHF2
-
Abcam antibodies for PHF2
- Invitrogen Antibodies for PHF2
- antibodies-online: Search results for available PHF2 related products ranked by validation data
- GeneTex PHF2 antibody for PHF2
- Sino Biological Antibodies for PHF2
Protein Products
-
OriGene Purified Proteins for PHF2
- Search Origene for MassSpec and Protein Over-expression Lysates for PHF2
- Origene Custom Protein Services for PHF2
- Novus Biologicals proteins for PHF2
- antibodies-online: Search results for 3 available PHF2 Proteins ranked by validation data
- Compare Top PHF2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for PHF2
-
Abcam proteins for PHF2
Assay Products
- antibodies-online: Search results for available PHF2 related products ranked by validation data
No data available for DME Specific Peptides for PHF2 Gene
Domains & Families for PHF2 Gene
Gene Families for PHF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PHF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PHF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75151UniProtKB/Swiss-Prot:
PHF2_HUMAN :- The PHD-type zinc finger mediates the binding to H3K4me2 and H3K4me3.
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
- Domain:
-
- The PHD-type zinc finger mediates the binding to H3K4me2 and H3K4me3.
- Family:
-
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Function for PHF2 Gene
Molecular function for PHF2 Gene
- GENATLAS Biochemistry:
- PHD finger protein 2,Drosophila polycomb group homolog,PcG,widespread expressed
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Enzymatically inactive by itself, and become active following phosphorylation by PKA.
- UniProtKB/Swiss-Prot Function:
- Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated Lys-9 of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated Lys-4 of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Enzyme Numbers (IUBMB) for PHF2 Gene
Phenotypes From GWAS Catalog for PHF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | contributes_to transcription coactivator activity | IDA | 21532585 |
| GO:0005506 | iron ion binding | IDA | 21167174 |
| GO:0005515 | protein binding | IPI | 21532585 |
| GO:0008270 | zinc ion binding | IDA | 20129925 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for PHF2 Gene
- MGI mutant phenotypes for PHF2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PHF2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Strongly decreased CFP-tsO45G cell surface transport
- Increased cell death HMECs cells
- Decreased influenza A/WSN/33 replication
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased HIV-1 infection
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Models for PHF2 Gene
- MGI Knock Outs for PHF2:
-
- Phf2 tm1.1Yima
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHF2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PHF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PHF2 gene
- Search ViGene Biosciences for PHF2
CRISPR Products
-
OriGene CRISPR knockouts for PHF2
- genomics-online: gRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- Applied Biological Materials CRISPR for PHF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHF2
- GenScript: Design CRISPR guide RNA sequences for PHF2
miRNA Products
- Search ViGene Biosciences for PHF2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for PHF2
- Browse OriGene Inhibitory RNA Products For PHF2
- genomics-online: shRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PHF2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PHF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PHF2
- Applied Biological Materials Clones for PHF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PHF2
-
ViGene Biosciences adenoviral particle packaged cDNA for PHF2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PHF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PHF2 gene
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PHF2 Gene
Localization for PHF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHF2 Gene
- Nucleus, nucleolus. Chromosome, centromere, kinetochore.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA,IDA | 20813266 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | TAS | 10051327 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PHF2 Gene
Pathways & Interactions for PHF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
Pathways by source for PHF2 Gene
1 Cell Signaling Technology pathway for PHF2 Gene
3 Reactome pathways for PHF2 Gene
Interacting Proteins for PHF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001889 | liver development | TAS | 21532585 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006482 | protein demethylation | IDA | 21532585 |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for SIGNOR curated interactions for PHF2 Gene
Transcripts for PHF2 Gene
mRNA/cDNA for PHF2 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (192) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PHF2
- genomics-online: gRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- Applied Biological Materials CRISPR for PHF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHF2
- GenScript: Design CRISPR guide RNA sequences for PHF2
miRNA Products
- Search ViGene Biosciences for PHF2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for PHF2
- Browse OriGene Inhibitory RNA Products For PHF2
- genomics-online: shRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PHF2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PHF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PHF2
- Applied Biological Materials Clones for PHF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 18c | ^ | 19a | · | 19b | · | 19c |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | - | - | |||||
| SP7: |
Expression for PHF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Eye (Sensory Organs)
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Neural Tube (Nervous System)
- Thymus (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (16.4), Placenta (10.9), CD8 Tcells (8.6), and Pancreatic juice (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHF2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PHF2 Gene:
PHF2SOURCE GeneReport for Unigene cluster for PHF2 Gene:
Hs.211441mRNA Expression by UniProt/SwissProt for PHF2 Gene:
O75151-PHF2_HUMAN
Tissue specificity:
Widely expressed, including in liver (at protein level).
Evidence on tissue expression from TISSUES for PHF2 Gene
- Nervous system(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for PHF2
- genomics-online: primer clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHF2 Gene
Orthologs for PHF2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PHF2 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PHF2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PHF2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Phf2 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PHF2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Phf2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PHF2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PHF2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PHF2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | phf2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | phf2 33 34 |
|
||
| wufa14c10 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | F29B9.2a 35 |
|
|
|
| F29B9.2b 35 |
|
|
|||
| spt-3 35 |
|
|
|||
| jmjd-1.1 34 |
|
ManyToMany | |||
| jmjd-1.2 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD1 34 |
|
OneToMany |
- Species where no ortholog for PHF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PHF2 Gene
(2) SIMAP similar genes for PHF2 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for PHF2 Gene
Variants for PHF2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921057 | uncertain-significance, Malignant tumor of prostate | 93,673,799(+) | G/A/C | coding_sequence_variant, missense_variant | |
| rs1000095901 | -- | 93,579,686(+) | G/C | intron_variant | |
| rs1000111733 | -- | 93,678,873(+) | A/T | 3_prime_UTR_variant | |
| rs1000163363 | -- | 93,578,411(+) | G/T | intron_variant | |
| rs1000164269 | -- | 93,583,983(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv824985 | CNV | gain | 20364138 |
| nsv824984 | CNV | gain | 20364138 |
| nsv519449 | CNV | loss | 19592680 |
| nsv512992 | CNV | insertion | 21212237 |
| nsv509311 | CNV | insertion | 20534489 |
| nsv1149043 | CNV | duplication | 26484159 |
| nsv1145256 | CNV | deletion | 24896259 |
| nsv1139996 | CNV | duplication | 24896259 |
| nsv1137483 | CNV | deletion | 24896259 |
| nsv1110039 | CNV | deletion | 24896259 |
| nsv1076192 | CNV | deletion | 25765185 |
| nsv1036609 | CNV | gain | 25217958 |
| esv3573292 | CNV | loss | 25503493 |
| esv3440136 | CNV | duplication | 20981092 |
| esv3421237 | CNV | duplication | 20981092 |
| esv3358961 | CNV | duplication | 20981092 |
| esv3350789 | CNV | duplication | 20981092 |
| esv28910 | CNV | loss | 19812545 |
| esv2738792 | CNV | deletion | 23290073 |
| esv2738791 | CNV | deletion | 23290073 |
| esv2738790 | CNV | deletion | 23290073 |
| esv2738789 | CNV | deletion | 23290073 |
| esv2738788 | CNV | deletion | 23290073 |
| esv2668862 | CNV | deletion | 23128226 |
| esv2631126 | CNV | insertion | 19546169 |
| esv1581383 | CNV | deletion | 17803354 |
| dgv7688n100 | CNV | gain | 25217958 |
| dgv4485e59 | CNV | duplication | 20981092 |
Residual Variation Intolerance Score:
35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.61;
96.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHF2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF2 Gene
Disorders for PHF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| decubitus ulcer |
|
|
Search PHF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PHF2 Gene
Publications for PHF2 Gene
- Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. (PMID: 20129925) Wen H … Shi X (The Journal of biological chemistry 2010) 2 3 4 58
- PHF2, a novel PHD finger gene located on human chromosome 9q22. (PMID: 10051327) Hasenpusch-Theil K … Frischauf AM (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 58
- PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. (PMID: 21532585) Baba A … Kato S (Nature cell biology 2011) 3 4 58
- Structural basis for human PHF2 Jumonji domain interaction with metal ions. (PMID: 21167174) Horton JR … Cheng X (Journal of molecular biology 2011) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for PHF2 Gene
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- Browse Sino Biological cDNA Clones
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for PHF2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHF2
- VectorBuilder custom plasmid, inducible vectors for PHF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHF2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PHF2
- antibodies-online: Search results for available PHF2 related products ranked by validation data
- antibodies-online: Search results for available PHF2 related products ranked by validation data
- antibodies-online: Search results for 3 available PHF2 Proteins ranked by validation data
- Compare Top PHF2 Proteins
- Quality Products:
- GeneTex PHF2 antibody for PHF2
- Search GeneTex for Proteins for PHF2
- ViGene Biosciences adenoviral particle packaged cDNA for PHF2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PHF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PHF2 gene
- Search ViGene Biosciences for PHF2
- Horizon Cell Lines for PHF2
- genomics-online: cdna clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- orf clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- genomics-online: gRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- genomics-online: primer clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
- genomics-online: shRNA clones - Search results for 75 available PHF2 gene related products
- Overview of 75 available PHF2 gene related products
Sources for PHF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew