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This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expre... See more...
Aliases for PHF2 Gene
Aliases for PHF2 Gene
External Ids for PHF2 Gene
- HGNC: 8920
- Entrez Gene: 5253
- Ensembl: ENSG00000197724
- OMIM: 604351
- UniProtKB: O75151
Previous GeneCards Identifiers for PHF2 Gene
- GC09U990060
- GC09P088066
- GC09P089638
- GC09P091680
- GC09P093418
- GC09P095378
- GC09P096338
- GC09P066069
Summaries for PHF2 Gene
-
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
GeneCards Summary for PHF2 Gene
PHF2 (PHD Finger Protein 2) is a Protein Coding gene. Diseases associated with PHF2 include Basidiobolomycosis and Culler-Jones Syndrome. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and methylated histone binding. An important paralog of this gene is PHF8.
UniProtKB/Swiss-Prot Summary for PHF2 Gene
-
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Additional gene information for PHF2 Gene
- HGNC(8920)
- Entrez Gene(5253)
- Ensembl(ENSG00000197724)
- OMIM(604351)
- UniProtKB(O75151)
- Open Targets Platform(ENSG00000197724)
- Search for PHF2 at DataMed
- Search for PHF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHF2 Gene
Genomics for PHF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PHF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PHF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHF2
- Top Transcription factor binding sites by QIAGEN in the PHF2 gene promoter:
-
- AREB6
- ITF-2
- Meis-1
- Meis-1a
- MyoD
- RSRFC4
- Tal-1beta
- TBP
- TFIID
Genomic Locations for PHF2 Gene
Genomic Locations for PHF2 Gene
- chr9:93,576,584-93,679,587
- (GRCh38/hg38)
- Size:
- 103,004 bases
- Orientation:
- Plus strand
- chr9:96,338,689-96,441,869
- (GRCh37/hg19)
- Size:
- 103,181 bases
- Orientation:
- Plus strand
Genomic View for PHF2 Gene
Genes around PHF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.31 by HGNC
- 9q22.31 by Entrez Gene
- 9q22.31 by Ensembl
PHF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHF2 Gene
Proteins for PHF2 Gene
-
Protein details for PHF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75151-PHF2_HUMAN
- Recommended name:
- Lysine-specific demethylase PHF2
- Protein Accession:
- O75151
- Q4VXG0
- Q8N3K2
- Q9Y6N4
Protein attributes for PHF2 Gene
- Size:
- 1096 amino acids
- Molecular mass:
- 120775 Da
- Quaternary structure:
-
- Component of the PHF2-ARID5B complex, at least composed of PHF2 and ARID5B. Interacts with HNF4A and NR1H4.
- SequenceCaution:
-
- Sequence=BAA31637.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for PHF2 Gene
Post-translational modifications for PHF2 Gene
- Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex.
-
Ubiquitination at Lys175, Lys412, and Lys427
- NX_O75151 (NX_O75151-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PHF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PHF2 Antibody
- Creative Diagnostics Anti-PHF2 (aa 2-100) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human PHF2 Antibody and Mouse Anti-PHF2 Recombinant Antibody (3E7)
- Novus Biologicals Antibodies for PHF2
-
Abcam antibodies for PHF2
- Invitrogen Antibodies for PHF2 (AFLGC-PHF2)
-
Boster Bio Antibodies for PHF2
- Sino Biological Antibodies for PHF2
Protein Products
-
OriGene Purified Proteins for PHF2
- Search Origene for MassSpec and Protein Over-expression Lysates for PHF2
- Origene Custom Protein Services for PHF2
- Novus Biologicals proteins for PHF2
- antibodies-online: Show 3 available PHF2 Proteins ranked by validation data
- Compare Top PHF2 Proteins
-
Quality Products:
-
Abcam proteins for PHF2
No data available for DME Specific Peptides for PHF2 Gene
Domains & Families for PHF2 Gene
Gene Families for PHF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PHF2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PHF2 Gene
- GenScript: Design optimal peptide antigens:
-
- PHD finger protein 2 (PHF2_HUMAN)
- PHF2 protein (Q6P2C5_HUMAN)
- PHF2 protein (Q8N359_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75151UniProtKB/Swiss-Prot:
PHF2_HUMAN :- The PHD-type zinc finger mediates the binding to H3K4me2 and H3K4me3.
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
- Domain:
-
- The PHD-type zinc finger mediates the binding to H3K4me2 and H3K4me3.
- Family:
-
- Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Function for PHF2 Gene
Molecular function for PHF2 Gene
- UniProtKB/Swiss-Prot Function:
- Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Enzymatically inactive by itself, and become active following phosphorylation by PKA.
- GENATLAS Biochemistry:
- PHD finger protein 2,Drosophila polycomb group homolog,PcG,widespread expressed
Enzyme Numbers (IUBMB) for PHF2 Gene
Phenotypes From GWAS Catalog for PHF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IDA | 21532585 |
| GO:0005506 | iron ion binding | IDA | 21167174 |
| GO:0005515 | protein binding | IPI | 21532585 |
| GO:0008270 | zinc ion binding | IDA | 20129925 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for PHF2 Gene
- MGI mutant phenotypes for PHF2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PHF2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- shRNA abundance <= 50%
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased viability ratio
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased HIV-1 infection
- Increased cell death in HCT116 cells
Animal Models for PHF2 Gene
- MGI Knock Outs for PHF2:
-
- Phf2 Phf2<tm1.1Yima>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PHF2 - Select products 50% OFF >
- * PHF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PHF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHF2
- Browse OriGene Inhibitory RNA Products For PHF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHF2
Clone Products
- Applied Biological Materials (abm): Clones for PHF2 - Select products 50% OFF >
- * PHF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for PHF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHF2
Cell Line Products
-
Horizon Cell Lines for PHF2
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PHF2 Gene
Localization for PHF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHF2 Gene
- Nucleus, nucleolus. Chromosome, centromere, kinetochore.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 1 |
- Nucleoli (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA,IDA | 20813266 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | TAS | 10051327 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for PHF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
Pathways by source for PHF2 Gene
3 Reactome pathways for PHF2 Gene
1 Cell Signaling Technology pathway for PHF2 Gene
Interacting Proteins for PHF2 Gene
GPS-Prot Interaction Network for PHF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001889 | liver development | TAS | 21532585 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006482 | protein demethylation | IDA | 21532585 |
| GO:0033169 | histone H3-K9 demethylation | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for PHF2 Gene
Transcripts for PHF2 Gene
mRNA/cDNA for PHF2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000359246 5392 nts (view in UCSC)
- ENST00000375376 3045 nts (view in UCSC)
- ENST00000610682 2921 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PHF2 - Select products 50% OFF >
- * PHF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PHF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHF2
- Browse OriGene Inhibitory RNA Products For PHF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHF2
Clone Products
- Applied Biological Materials (abm): Clones for PHF2 - Select products 50% OFF >
- * PHF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for PHF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHF2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 18c | ^ | 19a | · | 19b | · | 19c |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | - | - | |||||
| SP7: |
Relevant External Links for PHF2 Gene
- GeneLoc Exon Structure for
- PHF2
Expression for PHF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Eye (Sensory Organs)
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Neural Tube (Nervous System)
- Thymus (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (16.4), Placenta (10.9), CD8 Tcells (8.6), and Pancreatic juice (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHF2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHF2
SOURCE GeneReport for Unigene cluster for PHF2 Gene:
Hs.211441mRNA Expression by UniProt/SwissProt for PHF2 Gene:
O75151-PHF2_HUMAN
Tissue specificity:
Widely expressed, including in liver (at protein level).
Evidence on tissue expression from TISSUES for PHF2 Gene
- Nervous system(4.5)
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for PHF2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHF2 Gene
Orthologs for PHF2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PHF2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PHF2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PHF2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Phf2 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PHF2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Phf2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PHF2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PHF2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PHF2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | phf2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | phf2 30 31 |
|
OneToOne | |
| wufa14c10 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | F29B9.2a 32 |
|
|
|
| F29B9.2b 32 |
|
|
|||
| spt-3 32 |
|
|
|||
| jmjd-1.1 31 |
|
ManyToMany | |||
| jmjd-1.2 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD1 31 |
|
OneToMany |
- Species where no ortholog for PHF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PHF2 Gene
- ENSEMBL:
- Gene Tree for PHF2 (if available)
- TreeFam:
- Gene Tree for PHF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PHF2: view image
Paralogs for PHF2 Gene
(2) SIMAP similar genes for PHF2 Gene using alignment to 4 proteins:
- PHF2_HUMAN
- E7ET14_HUMAN
- Q6P2C5_HUMAN
- Q8N359_HUMAN
Pseudogenes.org Pseudogenes for PHF2 Gene
Variants for PHF2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHF2 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709466 | Benign: not provided | 93,673,594(+) | G/A | SYNONYMOUS_VARIANT | |
| 722562 | Benign: not provided | 93,676,725(+) | G/T | SYNONYMOUS_VARIANT | |
| 729446 | Benign: not provided | 93,674,979(+) | G/A | SYNONYMOUS_VARIANT | |
| 731722 | Benign: not provided | 93,636,532(+) | T/A | INTRON_VARIANT | |
| 733486 | Benign: not provided | 93,663,633(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4485e59 | CNV | duplication | 20981092 |
| dgv7688n100 | CNV | gain | 25217958 |
| esv1581383 | CNV | deletion | 17803354 |
| esv2631126 | CNV | insertion | 19546169 |
| esv2668862 | CNV | deletion | 23128226 |
| esv2738788 | CNV | deletion | 23290073 |
| esv2738789 | CNV | deletion | 23290073 |
| esv2738790 | CNV | deletion | 23290073 |
| esv2738791 | CNV | deletion | 23290073 |
| esv2738792 | CNV | deletion | 23290073 |
| esv28910 | CNV | loss | 19812545 |
| esv3350789 | CNV | duplication | 20981092 |
| esv3358961 | CNV | duplication | 20981092 |
| esv3421237 | CNV | duplication | 20981092 |
| esv3440136 | CNV | duplication | 20981092 |
| esv3573292 | CNV | loss | 25503493 |
| nsv1036609 | CNV | gain | 25217958 |
| nsv1076192 | CNV | deletion | 25765185 |
| nsv1110039 | CNV | deletion | 24896259 |
| nsv1137483 | CNV | deletion | 24896259 |
| nsv1139996 | CNV | duplication | 24896259 |
| nsv1145256 | CNV | deletion | 24896259 |
| nsv1149043 | CNV | duplication | 26484159 |
| nsv509311 | CNV | insertion | 20534489 |
| nsv512992 | CNV | insertion | 21212237 |
| nsv519449 | CNV | loss | 19592680 |
| nsv824984 | CNV | gain | 20364138 |
| nsv824985 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.61;
96.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF2 Gene
Disorders for PHF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| basidiobolomycosis |
|
|
| culler-jones syndrome |
|
|
| dissociative disorder |
|
|
| decubitus ulcer |
|
|
Search PHF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PHF2 Gene
Publications for PHF2 Gene
- Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. (PMID: 20129925) Wen H … Shi X (The Journal of biological chemistry 2010) 2 3 4
- PHF2, a novel PHD finger gene located on human chromosome 9q22. (PMID: 10051327) Hasenpusch-Theil K … Frischauf AM (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4
- Structural basis for human PHF2 Jumonji domain interaction with metal ions. (PMID: 21167174) Horton JR … Cheng X (Journal of molecular biology 2011) 3 4
- PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. (PMID: 21532585) Baba A … Kato S (Nature cell biology 2011) 3 4
- The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4
ExternalLinks
Products for PHF2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PHF2
- Search Origene for MassSpec and Protein Over-expression Lysates for PHF2
- Origene Custom Protein Services for PHF2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHF2
- Browse OriGene Inhibitory RNA Products For PHF2
- OriGene qPCR primer pairs for PHF2
- OriGene CRISPR knockouts for PHF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PHF2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PHF2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PHF2
- Novus Biologicals proteins for PHF2
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- Abcam antibodies for PHF2
- Abcam proteins for PHF2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for PHF2 (AFLGC-PHF2)
- VectorBuilder Custom and pre-made DNA vectors for PHF2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PHF2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PHF2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PHF2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PHF2
- Addgene plasmids for PHF2
- antibodies-online: Show 21 available PHF2 Antibodies ranked by validation data
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- antibodies-online: Search results for available PHF2 related products ranked by validation data
- antibodies-online: Show 3 available PHF2 Proteins ranked by validation data
- Compare Top PHF2 Proteins
- Quality Products:
- Horizon Cell Lines for PHF2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHF2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PHF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHF2
- Boster Bio Antibodies for PHF2
- Browse Boster Bio ELISA Kits
Sources for PHF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB