Aliases for PHF19 Gene
External Ids for PHF19 Gene
Previous GeneCards Identifiers for PHF19 Gene
GeneCards Summary for PHF19 Gene
PHF19 (PHD Finger Protein 19) is a Protein Coding gene. Diseases associated with PHF19 include Hereditary Lymphedema and Hereditary Lymphedema I. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include methylated histone binding. An important paralog of this gene is MTF2.
UniProtKB/Swiss-Prot Summary for PHF19 Gene
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.