Aliases for PHF12 Gene
External Ids for PHF12 Gene
Previous GeneCards Identifiers for PHF12 Gene
GeneCards Summary for PHF12 Gene
PHF12 (PHD Finger Protein 12) is a Protein Coding gene. Diseases associated with PHF12 include Spastic Paraplegia 23 and Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and transcription corepressor binding. An important paralog of this gene is AIRE.
UniProtKB/Swiss-Prot for PHF12 Gene
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.