Aliases for PHC2 Gene
External Ids for PHC2 Gene
Previous HGNC Symbols for PHC2 Gene
Previous GeneCards Identifiers for PHC2 Gene
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PHC2 Gene
PHC2 (Polyhomeotic Homolog 2) is a Protein Coding gene. Diseases associated with PHC2 include Conventional Angiosarcoma and Form Agnosia. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and identical protein binding. An important paralog of this gene is PHC3.
UniProtKB/Swiss-Prot Summary for PHC2 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.