Aliases for PHC1 Gene
External Ids for PHC1 Gene
Previous HGNC Symbols for PHC1 Gene
Previous GeneCards Identifiers for PHC1 Gene
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for PHC1 Gene
PHC1 (Polyhomeotic Homolog 1) is a Protein Coding gene. Diseases associated with PHC1 include Microcephaly 11, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is PHC2.
UniProtKB/Swiss-Prot Summary for PHC1 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.