Aliases for PHB2 Gene

Aliases for PHB2 Gene

  • Prohibitin 2 2 3 5
  • B-Cell Receptor-Associated Protein BAP37 3 4
  • Repressor Of Estrogen Receptor Activity 3 4
  • Prohibitin-2 3 4
  • D-Prohibitin 3 4
  • BAP 3 4
  • REA 3 4
  • B-Cell Associated Protein 3
  • PNAS-141 3
  • BCAP37 3
  • Bap37 3
  • HBAP 3
  • P22 3

External Ids for PHB2 Gene

Previous GeneCards Identifiers for PHB2 Gene

  • GC12M006945
  • GC12M007074

Summaries for PHB2 Gene

GeneCards Summary for PHB2 Gene

PHB2 (Prohibitin 2) is a Protein Coding gene. Diseases associated with PHB2 include Breast Medullary Carcinoma and 3-Methylglutaconic Aciduria, Type V. Among its related pathways are GPCR Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Gene Ontology (GO) annotations related to this gene include estrogen receptor binding. An important paralog of this gene is PHB.

UniProtKB/Swiss-Prot Summary for PHB2 Gene

  • Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).

Gene Wiki entry for PHB2 Gene

Additional gene information for PHB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHB2 Gene

Genomics for PHB2 Gene

GeneHancer (GH) Regulatory Elements for PHB2 Gene

Promoters and enhancers for PHB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PHB2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHB2

Top Transcription factor binding sites by QIAGEN in the PHB2 gene promoter:
  • HFH-1
  • MyoD
  • Sp1
  • SRF

Genomic Locations for PHB2 Gene

Genomic Locations for PHB2 Gene
chr12:6,965,327-6,970,823
(GRCh38/hg38)
Size:
5,497 bases
Orientation:
Minus strand
chr12:7,074,490-7,079,988
(GRCh37/hg19)
Size:
5,499 bases
Orientation:
Minus strand

Genomic View for PHB2 Gene

Genes around PHB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB2 Gene

Proteins for PHB2 Gene

  • Protein details for PHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99623-PHB2_HUMAN
    Recommended name:
    Prohibitin-2
    Protein Accession:
    Q99623
    Secondary Accessions:
    • B4DP75
    • Q2YDA4
    • Q7KYU3
    • Q92978

    Protein attributes for PHB2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33296 Da
    Quaternary structure:
    • Interacts with PHB (PubMed:20959514). Interacts with ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786). Interacts with SPHK2. Interacts with COX4I1; the interaction associates PHB2 with COX (By similarity).

    Three dimensional structures from OCA and Proteopedia for PHB2 Gene

    Alternative splice isoforms for PHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB2 Gene

Post-translational modifications for PHB2 Gene

  • Ubiquitination at Lys6, Lys97, Lys147, Lys224, and Lys244
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHB2 Gene

Domains & Families for PHB2 Gene

Gene Families for PHB2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PHB2 Gene

Blocks:
  • Prohibitin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PHB2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56579, highly similar to Prohibitin-2 (B4DP75_HUMAN)
  • cDNA FLJ60175, highly similar to Prohibitin-2 (B4DW05_HUMAN)
  • Repressor of estrogen receptor activity (PHB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99623

UniProtKB/Swiss-Prot:

PHB2_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB2: view

Function for PHB2 Gene

Molecular function for PHB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Phenotypes From GWAS Catalog for PHB2 Gene

Gene Ontology (GO) - Molecular Function for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359819
GO:0008022 protein C-terminus binding IPI 19906925
GO:0030331 estrogen receptor binding NAS 10359819
GO:0033218 amide binding IPI 19116139
GO:0046625 sphingolipid binding IDA 20959514
genes like me logo Genes that share ontologies with PHB2: view
genes like me logo Genes that share phenotypes with PHB2: view

Animal Models for PHB2 Gene

MGI Knock Outs for PHB2:
  • Phb2 Phb2<tm1.1Tlan>
  • Phb2 Phb2<tm1Katz>

miRNA for PHB2 Gene

miRTarBase miRNAs that target PHB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHB2 Gene

Localization for PHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB2 Gene

Mitochondrion inner membrane. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA,IDA 19116139
GO:0005739 mitochondrion IDA 19906925
GO:0005741 mitochondrial outer membrane IDA 17008324
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with PHB2: view

Pathways & Interactions for PHB2 Gene

PathCards logo

SuperPathways for PHB2 Gene

genes like me logo Genes that share pathways with PHB2: view

Pathways by source for PHB2 Gene

1 R&D Systems pathway for PHB2 Gene
1 Qiagen pathway for PHB2 Gene
  • Estrogen Pathway

SIGNOR curated interactions for PHB2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 17008324
GO:0006851 mitochondrial calcium ion transmembrane transport TAS --
GO:0007005 mitochondrion organization IMP 17008324
GO:0007062 sister chromatid cohesion IDA 23548868
GO:0009611 response to wounding IEA --
genes like me logo Genes that share ontologies with PHB2: view

Drugs & Compounds for PHB2 Gene

(5) Drugs for PHB2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capsaicin Approved Pharma Potentiation, Activator, Target TRPV1 receptor agonist 215
Didesmethylrocaglamide Experimental Pharma Target, inhibitor 0
Rocaglamide Experimental Pharma Target, inhibitor 0
genes like me logo Genes that share compounds with PHB2: view

Transcripts for PHB2 Gene

mRNA/cDNA for PHB2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHB2 Gene

No ASD Table

Relevant External Links for PHB2 Gene

GeneLoc Exon Structure for
PHB2

Expression for PHB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHB2 Gene

This gene is overexpressed in Nasal epithelium (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHB2 Gene



Protein tissue co-expression partners for PHB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHB2

SOURCE GeneReport for Unigene cluster for PHB2 Gene:

Hs.504620

Evidence on tissue expression from TISSUES for PHB2 Gene

  • Skin(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Lymph node(4.5)
  • Spleen(4.5)
  • Nervous system(4.5)
  • Lung(3.9)
  • Eye(3.8)
  • Intestine(3.8)
  • Pancreas(3.8)
  • Muscle(3.1)
  • Heart(2.7)
  • Kidney(2.6)
  • Stomach(2.5)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with PHB2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB2 Gene

Orthologs for PHB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB2 30
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB2 31 30
  • 91.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Phb2 17 31 30
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia PHB2 31 30
  • 90.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phb2 30
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHB2 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHB2 31 30
  • 81.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHB2 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phb2 30
  • 76.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15834 30
zebrafish
(Danio rerio)
Actinopterygii phb2a 31
  • 77 (a)
OneToMany
phb2b 31 30
  • 70.82 (n)
OneToMany
-- 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009642 30
  • 69.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)03709 31 30
  • 69.04 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea phb-2 31 30
  • 60.24 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL141W 30
  • 61.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB2 31 30
  • 57.84 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15731g 30
  • 55.23 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB1 30
  • 55.88 (n)
rice
(Oryza sativa)
Liliopsida Os07g0262200 30
  • 58.24 (n)
Os.32013 30
wheat
(Triticum aestivum)
Liliopsida Ta.14391 30
corn
(Zea mays)
Liliopsida Zm.496 30
barley
(Hordeum vulgare)
Liliopsida Hv.3698 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7966 31
  • 64 (a)
OneToOne
Cin.4663 30
bread mold
(Neurospora crassa)
Ascomycetes NCU03310 30
  • 57.69 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb2 30
  • 55.72 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4663 30
Species where no ortholog for PHB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB2 Gene

ENSEMBL:
Gene Tree for PHB2 (if available)
TreeFam:
Gene Tree for PHB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PHB2: view image

Paralogs for PHB2 Gene

Paralogs for PHB2 Gene

(3) SIMAP similar genes for PHB2 Gene using alignment to 8 proteins:

  • PHB2_HUMAN
  • F5GWA7_HUMAN
  • F5GY37_HUMAN
  • F5H0C5_HUMAN
  • F5H2D2_HUMAN
  • F5H3X6_HUMAN
  • J3KPX7_HUMAN
  • U3KPZ5_HUMAN

Pseudogenes.org Pseudogenes for PHB2 Gene

genes like me logo Genes that share paralogs with PHB2: view

Variants for PHB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHB2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
709112 Benign: not provided 6,966,468(-) T/C SYNONYMOUS_VARIANT
712104 Benign: not provided 6,965,706(-) G/A SYNONYMOUS_VARIANT
725611 Benign: not provided 6,965,713(-) CTG/C SPLICE_ACCEPTOR_VARIANT

Additional dbSNP identifiers (rs#s) for PHB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PHB2 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Variation tolerance for PHB2 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHB2 Gene

Human Gene Mutation Database (HGMD)
PHB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB2 Gene

Disorders for PHB2 Gene