This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript varia... See more...

Aliases for PHB Gene

Aliases for PHB Gene

  • Prohibitin 2 3 4 5
  • Epididymis Secretory Sperm Binding Protein Li 54e 3
  • Epididymis Luminal Protein 215 3
  • HEL-S-54e 3
  • HEL-215 3
  • PHB1 3

External Ids for PHB Gene

Previous GeneCards Identifiers for PHB Gene

  • GC17M047192
  • GC17M049961
  • GC17M047823
  • GC17M047956
  • GC17M044836
  • GC17M047481
  • GC17M042846

Summaries for PHB Gene

Entrez Gene Summary for PHB Gene

  • This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHB Gene

PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.

UniProtKB/Swiss-Prot Summary for PHB Gene

  • Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB Gene

Additional gene information for PHB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHB Gene

Genomics for PHB Gene

GeneHancer (GH) Regulatory Elements for PHB Gene

Promoters and enhancers for PHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PHB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHB

Top Transcription factor binding sites by QIAGEN in the PHB gene promoter:
  • AML1a
  • CP1A
  • CUTL1
  • GATA-3
  • MyoD
  • POU3F2
  • RORalpha1
  • SRY
  • STAT3
  • STAT5A

Genomic Locations for PHB Gene

Genomic Locations for PHB Gene
chr17:49,404,048-49,414,905
(GRCh38/hg38)
Size:
10,858 bases
Orientation:
Minus strand
chr17:47,481,414-47,492,246
(GRCh37/hg19)
Size:
10,833 bases
Orientation:
Minus strand

Genomic View for PHB Gene

Genes around PHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB Gene

Proteins for PHB Gene

  • Protein details for PHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35232-PHB_HUMAN
    Recommended name:
    Prohibitin
    Protein Accession:
    P35232
    Secondary Accessions:
    • B4DY47
    • Q4VBQ0

    Protein attributes for PHB Gene

    Size:
    272 amino acids
    Molecular mass:
    29804 Da
    Quaternary structure:
    • Interacts with PHB2 (PubMed:11302691, PubMed:20959514). Interacts with STOML2 (PubMed:21746876).

    Three dimensional structures from OCA and Proteopedia for PHB Gene

    Alternative splice isoforms for PHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB Gene

Post-translational modifications for PHB Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PHB Gene

Domains & Families for PHB Gene

Gene Families for PHB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PHB Gene

Blocks:
  • Prohibitin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PHB Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA (A8K401_HUMAN)
  • cDNA FLJ51562, highly similar to Prohibitin (B4DY47_HUMAN)
  • Prohibitin (PHB_HUMAN)
  • PHB protein (Q6FHP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35232

UniProtKB/Swiss-Prot:

PHB_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB: view

Function for PHB Gene

Molecular function for PHB Gene

UniProtKB/Swiss-Prot Function:
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
GENATLAS Biochemistry:
prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function

Phenotypes From GWAS Catalog for PHB Gene

Gene Ontology (GO) - Molecular Function for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001850 complement component C3a binding IDA 17070910
GO:0001851 complement component C3b binding IDA 17070910
GO:0005515 protein binding IPI 11302691
GO:0008022 protein C-terminus binding IPI 19906925
GO:0019899 enzyme binding IPI 23921388
genes like me logo Genes that share ontologies with PHB: view
genes like me logo Genes that share phenotypes with PHB: view

Human Phenotype Ontology for PHB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PHB Gene

MGI Knock Outs for PHB:
  • Phb Phb<tm1.2Bwo>

Animal Model Products

  • Taconic Biosciences Mouse Models for PHB

miRNA for PHB Gene

Clone Products

  • Addgene plasmids for PHB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PHB Gene

Localization for PHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene

Mitochondrion inner membrane. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 5
endosome 5
cytosol 3
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm IDA 12466959
GO:0005737 cytoplasm IDA 16964284
GO:0005739 mitochondrion IEA,IDA 24732013
GO:0005743 mitochondrial inner membrane TAS 14500729
genes like me logo Genes that share ontologies with PHB: view

Pathways & Interactions for PHB Gene

PathCards logo

SuperPathways for PHB Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with PHB: view

Pathways by source for PHB Gene

1 R&D Systems pathway for PHB Gene
1 Cell Signaling Technology pathway for PHB Gene

Gene Ontology (GO) - Biological Process for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16964284
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006355 regulation of transcription, DNA-templated IDA 14500729
GO:0006851 mitochondrial calcium ion transmembrane transport TAS --
GO:0007005 mitochondrion organization IMP 17008324
genes like me logo Genes that share ontologies with PHB: view

No data available for SIGNOR curated interactions for PHB Gene

Drugs & Compounds for PHB Gene

(13) Drugs for PHB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Didesmethylrocaglamide Experimental Pharma Target, inhibitor 0
Rocaglamide Experimental Pharma Target, inhibitor 0

(9) Additional Compounds for PHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PHB: view

Transcripts for PHB Gene

mRNA/cDNA for PHB Gene

4 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for PHB

Alternative Splicing Database (ASD) splice patterns (SP) for PHB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PHB Gene

GeneLoc Exon Structure for
PHB

Expression for PHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PHB Gene

Protein differential expression in normal tissues from HIPED for PHB Gene

This gene is overexpressed in Nasal epithelium (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHB Gene



Protein tissue co-expression partners for PHB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHB

SOURCE GeneReport for Unigene cluster for PHB Gene:

Hs.514303

mRNA Expression by UniProt/SwissProt for PHB Gene:

P35232-PHB_HUMAN
Tissue specificity: Widely expressed in different tissues.

Evidence on tissue expression from TISSUES for PHB Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Lung(4.8)
  • Muscle(4.7)
  • Intestine(4.1)
  • Skin(4.1)
  • Kidney(3.4)
  • Eye(3.3)
  • Pancreas(3.3)
  • Heart(2.9)
  • Stomach(2.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene

Orthologs for PHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB 31 30
  • 99.75 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHB 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB 31 31 30
  • 93.5 (n)
OneToMany
-- 31
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PHB 31 30
  • 93.01 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHB 31
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phb 30
  • 91.54 (n)
mouse
(Mus musculus)
Mammalia Phb 17 31 30
  • 91.18 (n)
chicken
(Gallus gallus)
Aves -- 31
  • 89 (a)
OneToMany
PHB 31 30
  • 82.84 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 92 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia phb 30
  • 78.8 (n)
MGC75944 30
African clawed frog
(Xenopus laevis)
Amphibia MGC64447 30
zebrafish
(Danio rerio)
Actinopterygii phb 31 30 30
  • 77.9 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10205 30
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cc 31 32 30
  • 68.51 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009323 30
  • 67.03 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.9 32
  • 68 (a)
phb-1 31 30
  • 62.21 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR313C 30
  • 60.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB1 33 31 30
  • 56.82 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16302g 30
  • 55.71 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB3 30
  • 56.63 (n)
soybean
(Glycine max)
eudicotyledons Gma.15151 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3157 30
rice
(Oryza sativa)
Liliopsida Os02g0580500 30
  • 57.95 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.24798 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6789 31
  • 71 (a)
OneToOne
Cin.4549 30
bread mold
(Neurospora crassa)
Ascomycetes NCU08946 30
  • 58.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb1 30
  • 56.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4549 30
Species where no ortholog for PHB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB Gene

ENSEMBL:
Gene Tree for PHB (if available)
TreeFam:
Gene Tree for PHB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PHB: view image

Paralogs for PHB Gene

Paralogs for PHB Gene

(3) SIMAP similar genes for PHB Gene using alignment to 9 proteins:

  • PHB_HUMAN
  • A8K401_HUMAN
  • B4DY47_HUMAN
  • C9JW96_HUMAN
  • C9JZ20_HUMAN
  • D6RBK0_HUMAN
  • E7ESE2_HUMAN
  • E9PCW0_HUMAN
  • Q6FHP5_HUMAN
genes like me logo Genes that share paralogs with PHB: view

Variants for PHB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHB Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
784359 Benign: not provided 49,405,058(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
rs112294663 Risk Factor: Breast cancer, susceptibility to 49,404,263(-) G/A THREE_PRIME_UTR_VARIANT
rs121918372 A breast cancer sample p.Arg105His
rs121918373 A breast cancer sample p.Val88Ala

Additional dbSNP identifiers (rs#s) for PHB Gene

Structural Variations from Database of Genomic Variants (DGV) for PHB Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV gain+loss 17160897
nsv960500 CNV duplication 23825009
nsv960501 CNV duplication 23825009
nsv960502 CNV duplication 23825009
nsv962338 CNV duplication 23825009
nsv978437 CNV duplication 23825009

Variation tolerance for PHB Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHB Gene

Human Gene Mutation Database (HGMD)
PHB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene

Disorders for PHB Gene

MalaCards: The human disease database

(10) MalaCards diseases for PHB Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
igg4-related disease
  • mediastinal fibrosis, familial
chikungunya
  • chikungunya fever
female breast cancer
  • female breast carcinoma
3-methylglutaconic aciduria, type iii
  • mgca3
- elite association - COSMIC cancer census association via MalaCards
Search PHB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PHB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PHB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene

Publications for PHB Gene

  1. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T … Nakamura Y (Genomics 1993) 2 3 4 23 54
  2. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A … Hamann U (BMC cancer 2008) 3 23 41 54
  3. The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C … Hefler LA (European journal of obstetrics, gynecology, and reproductive biology 2008) 3 23 41 54
  4. Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N … Ulusoy AN (DNA and cell biology 2008) 3 23 41 54
  5. The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PMID: 17004108) Jakubowska A … Hamann U (Breast cancer research and treatment 2007) 3 23 41 54

Products for PHB Gene

  • Addgene plasmids for PHB