This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript varia... See more...

Aliases for PHB Gene

Aliases for PHB Gene

  • Prohibitin 2 3 4 5
  • PHB1 2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 54e 3
  • Epididymis Luminal Protein 215 3
  • HEL-S-54e 3
  • HEL-215 3
  • PHB 5

External Ids for PHB Gene

Previous GeneCards Identifiers for PHB Gene

  • GC17M047192
  • GC17M049961
  • GC17M047823
  • GC17M047956
  • GC17M044836
  • GC17M047481
  • GC17M042846

Summaries for PHB Gene

Entrez Gene Summary for PHB Gene

  • This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHB Gene

PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Chikungunya. Among its related pathways are RET signaling and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.

UniProtKB/Swiss-Prot Summary for PHB Gene

  • Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
  • In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117).
  • In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195).
  • In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).

Gene Wiki entry for PHB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHB Gene

Genomics for PHB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PHB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHB

Top Transcription factor binding sites by QIAGEN in the PHB gene promoter:
  • AML1a
  • CP1A
  • CUTL1
  • GATA-3
  • MyoD
  • POU3F2
  • RORalpha1
  • SRY
  • STAT3
  • STAT5A

Genomic Locations for PHB Gene

Latest Assembly
chr17:49,404,052-49,414,901
(GRCh38/hg38)
Size:
10,850 bases
Orientation:
Minus strand

Previous Assembly
chr17:47,481,414-47,492,244
(GRCh37/hg19 by Entrez Gene)
Size:
10,831 bases
Orientation:
Minus strand

chr17:47,481,414-47,492,246
(GRCh37/hg19 by Ensembl)
Size:
10,833 bases
Orientation:
Minus strand

Genomic View for PHB Gene

Genes around PHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB Gene

Proteins for PHB Gene

  • Protein details for PHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35232-PHB_HUMAN
    Recommended name:
    Prohibitin
    Protein Accession:
    P35232
    Secondary Accessions:
    • B4DY47
    • Q4VBQ0

    Protein attributes for PHB Gene

    Size:
    272 amino acids
    Molecular mass:
    29804 Da
    Quaternary structure:
    • The mitochondrial prohibitin complex consists of two subunits (PHB and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Interacts with STOML2 (PubMed:21746876). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction requires PHB2 and takes place upon Parkin-mediated mitochondrial damage (PubMed:28017329). Interacts with STAT3 (unphosphorylated or phosphorylated at 'Ser-727') (PubMed:31899195). Interacts with CLPB (PubMed:31522117). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (By similarity).
    • (Microbial infection) Interacts with SARS coronavirus/SARS-CoV nsp2 protein.
    • (Microbial infection) Interacts with chikungunya virus spike glycoprotein E2.
    • (Microbial infection) Interaction with human immunodeficiency virus type 1/HIV-1 envelope glycoprotein GP160.
    • (Microbial infection) Interacts with human enterovirus 71/EV-71 capsid protein VP0, protein 3CD and protease 3C.

    Three dimensional structures from OCA and Proteopedia for PHB Gene

    Alternative splice isoforms for PHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB Gene

Post-translational modifications for PHB Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Antibodies for research

No data available for DME Specific Peptides for PHB Gene

Domains & Families for PHB Gene

Gene Families for PHB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PHB Gene

InterPro:
Blocks:
  • Prohibitin signature

Suggested Antigen Peptide Sequences for PHB Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA (A8K401_HUMAN)
  • cDNA FLJ51562, highly similar to Prohibitin (B4DY47_HUMAN)
  • Prohibitin (PHB_HUMAN)
  • PHB protein (Q6FHP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35232

UniProtKB/Swiss-Prot:

PHB_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB: view

Function for PHB Gene

Molecular function for PHB Gene

UniProtKB/Swiss-Prot Function:
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
UniProtKB/Swiss-Prot Function:
In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117).
UniProtKB/Swiss-Prot Function:
In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195).
UniProtKB/Swiss-Prot Function:
In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
GENATLAS Biochemistry:
prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function

Phenotypes From GWAS Catalog for PHB Gene

Gene Ontology (GO) - Molecular Function for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001850 complement component C3a binding IDA 17070910
GO:0001851 complement component C3b binding IDA 17070910
GO:0003714 transcription corepressor activity IDA 18487222
GO:0005515 protein binding IPI 11302691
GO:0008022 protein C-terminus binding IPI 19906925
genes like me logo Genes that share ontologies with PHB: view
genes like me logo Genes that share phenotypes with PHB: view

Human Phenotype Ontology for PHB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PHB Gene

MGI Knock Outs for PHB:
  • Phb Phb<tm1.2Bwo>

Animal Models for research

  • Taconic Biosciences Mouse Models for PHB

miRNA for PHB Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PHB Gene

Localization for PHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene

Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 5
endosome 5
extracellular 4
cytosol 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm IDA 12466959
GO:0005737 cytoplasm IEA,IDA 16964284
GO:0005739 mitochondrion IEA,IDA 24732013
GO:0005743 mitochondrial inner membrane IEA,TAS 14500729
genes like me logo Genes that share ontologies with PHB: view

Pathways & Interactions for PHB Gene

PathCards logo

SuperPathways for PHB Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with PHB: view

Pathways by source for PHB Gene

1 R&D Systems pathway for PHB Gene
1 Cell Signaling Technology pathway for PHB Gene

Gene Ontology (GO) - Biological Process for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16964284
GO:0001541 ovarian follicle development IEA --
GO:0001552 ovarian follicle atresia IEA --
GO:0001649 osteoblast differentiation HDA 16210410
GO:0002377 immunoglobulin production ISS --
genes like me logo Genes that share ontologies with PHB: view

No data available for SIGNOR curated interactions for PHB Gene

Drugs & Compounds for PHB Gene

(13) Drugs for PHB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Didesmethylrocaglamide Experimental Pharma Target, inhibitor 0
Rocaglamide Experimental Pharma Target, inhibitor 0

(9) Additional Compounds for PHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PHB: view

Transcripts for PHB Gene

mRNA/cDNA for PHB Gene

4 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB

Alternative Splicing Database (ASD) splice patterns (SP) for PHB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PHB Gene

GeneLoc Exon Structure for
PHB

Expression for PHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PHB Gene

Protein differential expression in normal tissues from HIPED for PHB Gene

This gene is overexpressed in Nasal epithelium (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHB Gene



Protein tissue co-expression partners for PHB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHB

SOURCE GeneReport for Unigene cluster for PHB Gene:

Hs.514303

mRNA Expression by UniProt/SwissProt for PHB Gene:

P35232-PHB_HUMAN
Tissue specificity: Widely expressed in different tissues.

Evidence on tissue expression from TISSUES for PHB Gene

  • Nervous system(5)
  • Liver(4.9)
  • Lung(4.8)
  • Muscle(4.7)
  • Skin(4.3)
  • Intestine(4.2)
  • Kidney(3.7)
  • Pancreas(3.7)
  • Eye(3.6)
  • Heart(3.4)
  • Stomach(2.8)
  • Blood(2.6)
  • Lymph node(2.5)
  • Bone(2.5)
  • Thyroid gland(2.4)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PHB: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene

Orthologs for PHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PHB 29 30
  • 99.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PHB 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PHB 29 30 30
  • 93.5 (n)
OneToMany
-- 30
  • 93 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia PHB 29 30
  • 93.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PHB 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Phb 29
  • 91.54 (n)
Mouse
(Mus musculus)
Mammalia Phb 29 16 30
  • 91.18 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 89 (a)
OneToMany
PHB 29 30
  • 82.84 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 92 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia phb 29
  • 78.8 (n)
MGC75944 29
African clawed frog
(Xenopus laevis)
Amphibia MGC64447 29
Zebrafish
(Danio rerio)
Actinopterygii phb 29 30
  • 77.9 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10205 29
Fruit Fly
(Drosophila melanogaster)
Insecta l(2)37Cc 29 30 31
  • 68.51 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009323 29
  • 67.03 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y37E3.9 31
  • 68 (a)
phb-1 29 30
  • 62.21 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR313C 29
  • 60.8 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB1 29 30 32
  • 56.82 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16302g 29
  • 55.71 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PHB3 29
  • 56.63 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3157 29
Soybean
(Glycine max)
eudicotyledons Gma.15151 29
Rice
(Oryza sativa)
Liliopsida Os02g0580500 29
  • 57.95 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.24798 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6789 30
  • 71 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU08946 29
  • 58.04 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb1 29
  • 56.58 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4549 29
Species where no ortholog for PHB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB Gene

ENSEMBL:
Gene Tree for PHB (if available)
TreeFam:
Gene Tree for PHB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PHB: view image
Alliance of Genome Resources:
Additional Orthologs for PHB

Paralogs for PHB Gene

Paralogs for PHB Gene

(3) SIMAP similar genes for PHB Gene using alignment to 9 proteins:

  • PHB_HUMAN
  • A8K401_HUMAN
  • B4DY47_HUMAN
  • C9JW96_HUMAN
  • C9JZ20_HUMAN
  • D6RBK0_HUMAN
  • E7ESE2_HUMAN
  • E9PCW0_HUMAN
  • Q6FHP5_HUMAN
genes like me logo Genes that share paralogs with PHB: view

Variants for PHB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHB Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs112294663 Risk Factor: Breast cancer, susceptibility to 49,404,263(-) G/A
PHB:c.*729C>T
THREE_PRIME_UTR
rs121918372 A breast cancer sample p.Arg105His
rs121918373 A breast cancer sample p.Val88Ala
rs2233670 Benign: not provided 49,405,058(-) G/A
NM_002634.4(PHB):c.753C>T (p.Leu251=)
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PHB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PHB Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV gain+loss 17160897
nsv960500 CNV duplication 23825009
nsv960501 CNV duplication 23825009
nsv960502 CNV duplication 23825009
nsv962338 CNV duplication 23825009
nsv978437 CNV duplication 23825009

Variation tolerance for PHB Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHB Gene

Human Gene Mutation Database (HGMD)
PHB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB
Leiden Open Variation Database (LOVD)
PHB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene

Disorders for PHB Gene

MalaCards: The human disease database

(11) MalaCards diseases for PHB Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
chikungunya
  • chikungunya fever
igg4-related disease
  • hyper-igg4 disease
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
parkinson disease 4, autosomal dominant
  • park4
- elite association - COSMIC cancer census association via MalaCards
Search PHB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PHB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PHB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene

Publications for PHB Gene

  1. Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility. (PMID: 11377649) Jupe ER … Thompson LF (Lancet (London, England) 2001) 3 22 40 72
  2. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T … Nakamura Y (Genomics 1993) 2 3 4 22
  3. Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N … Ulusoy AN (DNA and cell biology 2008) 3 22 40
  4. The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C … Hefler LA (European journal of obstetrics, gynecology, and reproductive biology 2008) 3 22 40
  5. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A … Hamann U (BMC cancer 2008) 3 22 40

Products for PHB Gene

  • Addgene plasmids for PHB

Sources for PHB Gene