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This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript varia... See more...
Aliases for PHB Gene
Aliases for PHB Gene
External Ids for PHB Gene
- HGNC: 8912
- NCBI Entrez Gene: 5245
- Ensembl: ENSG00000167085
- OMIM®: 176705
- UniProtKB/Swiss-Prot: P35232
Previous GeneCards Identifiers for PHB Gene
- GC17M047192
- GC17M049961
- GC17M047823
- GC17M047956
- GC17M044836
- GC17M047481
- GC17M042846
Summaries for PHB Gene
-
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PHB Gene
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Chikungunya. Among its related pathways are RET signaling and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.
UniProtKB/Swiss-Prot Summary for PHB Gene
-
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
-
In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117).
-
In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195).
-
In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
Additional gene information for PHB Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHB Gene
Genomics for PHB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PHB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHB
- Top Transcription factor binding sites by QIAGEN in the PHB gene promoter:
-
- AML1a
- CP1A
- CUTL1
- GATA-3
- MyoD
- POU3F2
- RORalpha1
- SRY
- STAT3
- STAT5A
Genomic Locations for PHB Gene
Latest Assembly
- chr17:49,404,052-49,414,901
- (GRCh38/hg38)
- Size:
- 10,850 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:47,481,414-47,492,244
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 10,831 bases
- Orientation:
- Minus strand
Genomic View for PHB Gene
Genes around PHB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by HGNC
- 17q21.33 by Entrez Gene
- 17q21.33 by Ensembl
PHB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHB Gene
Proteins for PHB Gene
-
Protein details for PHB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35232-PHB_HUMAN
- Recommended name:
- Prohibitin
- Protein Accession:
- P35232
- B4DY47
- Q4VBQ0
Protein attributes for PHB Gene
- Size:
- 272 amino acids
- Molecular mass:
- 29804 Da
- Quaternary structure:
-
- The mitochondrial prohibitin complex consists of two subunits (PHB and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Interacts with STOML2 (PubMed:21746876). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction requires PHB2 and takes place upon Parkin-mediated mitochondrial damage (PubMed:28017329). Interacts with STAT3 (unphosphorylated or phosphorylated at 'Ser-727') (PubMed:31899195). Interacts with CLPB (PubMed:31522117). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (By similarity).
- (Microbial infection) Interacts with SARS coronavirus/SARS-CoV nsp2 protein.
- (Microbial infection) Interacts with chikungunya virus spike glycoprotein E2.
- (Microbial infection) Interaction with human immunodeficiency virus type 1/HIV-1 envelope glycoprotein GP160.
- (Microbial infection) Interacts with human enterovirus 71/EV-71 capsid protein VP0, protein 3CD and protease 3C.
Protein Expression for PHB Gene
Post-translational modifications for PHB Gene
Other Protein References for PHB Gene
Antibodies for research
- LifeSpan BioSciences PHB / Prohibitin Antibody and PHB / Prohibitin Monoclonal Antibody
- G Biosciences Immunotag™ Prohibitin Antibody and Immunotag™ PHB Antibody
- NSJ Bioreagents Prohibitin Antibody (PHB1) and Prohibitin Antibody / PHB (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for PHB
- Novus Biologicals Antibodies for PHB
-
Abcam antibodies for PHB
- Invitrogen Antibodies for PHB (AFLGC-PHB)
- antibodies-online: Show 105 available Prohibitin Antibodies ranked by validation data
- Compare Top Prohibitin Antibodies
-
Recommended
- 195 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 82 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PHB
- Sino Biological Antibodies for PHB
Protein products for research
-
OriGene Purified Proteins for PHB
- Search Origene for MassSpec and Protein Over-expression Lysates for PHB
- Origene Custom Protein Services for PHB
- ProSpec Recombinant Proteins for PHB
-
Abcam proteins for PHB
Assay products for research
- G Biosciences Immunotag™ Human PHB (Prohibitin) ELISA
- Novus Biologicals ELISA Kits for PHB
- antibodies-online: Show 52 available Prohibitin Elisa Kits ranked by validation data
- Compare Top Prohibitin Elisa Kits
-
Quality Products:
- ABIN1116655
- ABIN820339
- ABIN415254
- ABIN1571841
- ABIN5521376
- ABIN5668697
- ABIN510518
- ABIN5658085
- ABIN2538191
- ABIN2950649
- ABIN1571842
- ABIN1116654
- ABIN415814
- ABIN5521377
- ABIN5669870
- ABIN512015
- ABIN5658086
- ABIN6254427
- ABIN2538192
- ABIN2950650
- ABIN431722
- ABIN1571843
- ABIN1116656
- ABIN5521378
- ABIN5670529
- ABIN511792
- ABIN5658087
- ABIN2538193
- ABIN2950651
- ABIN6206661
- ABIN1565762
- ABIN6206654
No data available for DME Specific Peptides for PHB Gene
Domains & Families for PHB Gene
Gene Families for PHB Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PHB Gene
- InterPro:
- Blocks:
-
- Prohibitin signature
Suggested Antigen Peptide Sequences for PHB Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA (A8K401_HUMAN)
- cDNA FLJ51562, highly similar to Prohibitin (B4DY47_HUMAN)
- Prohibitin (PHB_HUMAN)
- PHB protein (Q6FHP5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35232- Family:
-
- Belongs to the prohibitin family.
Function for PHB Gene
Molecular function for PHB Gene
- UniProtKB/Swiss-Prot Function:
- Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
- UniProtKB/Swiss-Prot Function:
- In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117).
- UniProtKB/Swiss-Prot Function:
- In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195).
- UniProtKB/Swiss-Prot Function:
- In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
- GENATLAS Biochemistry:
- prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function
Phenotypes From GWAS Catalog for PHB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001850 | complement component C3a binding | IDA | 17070910 |
| GO:0001851 | complement component C3b binding | IDA | 17070910 |
| GO:0003714 | transcription corepressor activity | IDA | 18487222 |
| GO:0005515 | protein binding | IPI | 11302691 |
| GO:0008022 | protein C-terminus binding | IPI | 19906925 |
Phenotypes for PHB Gene
- MGI mutant phenotypes for PHB:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for PHB:
-
- Increased vaccinia virus (VACV) infection
- Increased G1 DNA content
- shRNA abundance <= 25%
- shRNA abundance <= 50%
- Increased shRNA abundance (Z-score > 2)
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- G0/1 arrest
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, decreased peripheral FA formation
Animal Models for PHB Gene
- MGI Knock Outs for PHB:
-
- Phb Phb<tm1.2Bwo>
Animal Models for research
-
Taconic Biosciences Mouse Models for PHB
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PHB - Starting at $85 >
- * PHB CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
miRNA for PHB Gene
- miRTarBase miRNAs that target PHB
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Clone products for research
- Applied Biological Materials (abm): Clones for PHB - Starting at $45 >
- * PHB as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220824
- MR220824
- MR220824L1
- MR220824L2
- MR220824L3
- MR220824L4
- RC201229
- RC201229L1
- RC201229L2
- RC201229L3
- RC201229L4
- RC236119
- RC237072
- RC237073
- RG201229
- RR205193
- RR205193L1
- RR205193L2
- RR205193L3
- RR205193L4
- MR220824L1V
- MR220824L2V
- MR220824L3V
- MR220824L4V
- RC201229L1V
- RC201229L2V
- RC201229L3V
- RC201229L4V
- RR205193L1V
- RR205193L2V
- RR205193L3V
- RR205193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PHB
- Addgene plasmids for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PHB Gene
Localization for PHB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene
- Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| endosome | 5 |
| extracellular | 4 |
| cytosol | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005654 | nucleoplasm | IDA | 12466959 |
| GO:0005737 | cytoplasm | IEA,IDA | 16964284 |
| GO:0005739 | mitochondrion | IEA,IDA | 24732013 |
| GO:0005743 | mitochondrial inner membrane | IEA,TAS | 14500729 |
Pathways & Interactions for PHB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for PHB Gene
1 BioSystems pathway for PHB Gene
53 Reactome pathways for PHB Gene
1 R&D Systems pathway for PHB Gene
1 Cell Signaling Technology pathway for PHB Gene
Interacting Proteins for PHB Gene
Selected Interacting proteins:
P35232-PHB_HUMAN
ENSP00000479488
for PHB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PHB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 16964284 |
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001552 | ovarian follicle atresia | IEA | -- |
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0002377 | immunoglobulin production | ISS | -- |
No data available for SIGNOR curated interactions for PHB Gene
Transcripts for PHB Gene
mRNA/cDNA for PHB Gene
- 4 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300408 1834 nts (view in UCSC)
- ENST00000393345 847 nts (view in UCSC)
- ENST00000419140 1867 nts (view in UCSC)
- ENST00000434917 1174 nts (view in UCSC)
- ENST00000446735 1604 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PHB - Starting at $85 >
- * PHB CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Clone products for research
- Applied Biological Materials (abm): Clones for PHB - Starting at $45 >
- * PHB as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220824
- MR220824
- MR220824L1
- MR220824L2
- MR220824L3
- MR220824L4
- RC201229
- RC201229L1
- RC201229L2
- RC201229L3
- RC201229L4
- RC236119
- RC237072
- RC237073
- RG201229
- RR205193
- RR205193L1
- RR205193L2
- RR205193L3
- RR205193L4
- MR220824L1V
- MR220824L2V
- MR220824L3V
- MR220824L4V
- RC201229L1V
- RC201229L2V
- RC201229L3V
- RC201229L4V
- RR205193L1V
- RR205193L2V
- RR205193L3V
- RR205193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PHB
- Addgene plasmids for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for PHB Gene
- GeneLoc Exon Structure for
- PHB
Expression for PHB Gene
This gene is overexpressed in Nasal epithelium (25.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHB Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHB
SOURCE GeneReport for Unigene cluster for PHB Gene:
Hs.514303mRNA Expression by UniProt/SwissProt for PHB Gene:
P35232-PHB_HUMAN
Tissue specificity:
Widely expressed in different tissues.
Evidence on tissue expression from TISSUES for PHB Gene
- Nervous system(5)
- Liver(4.9)
- Lung(4.8)
- Muscle(4.7)
- Skin(4.3)
- Intestine(4.2)
- Kidney(3.7)
- Pancreas(3.7)
- Eye(3.6)
- Heart(3.4)
- Stomach(2.8)
- Blood(2.6)
- Lymph node(2.5)
- Bone(2.5)
- Thyroid gland(2.4)
- Bone marrow(2.4)
- Spleen(2.4)
- Adrenal gland(2.4)
- Gall bladder(2)
Primer products for research
-
OriGene qPCR primer pairs for PHB
-
OriGene qPCR primer pairs and template standards for PHB
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene
Orthologs for PHB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PHB 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PHB 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PHB 29 30 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | PHB 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PHB 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Phb 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Phb 29 16 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| PHB 29 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | phb 29 |
|
||
| MGC75944 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64447 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | phb 29 30 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10205 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)37Cc 29 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009323 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | Y37E3.9 31 |
|
|
|
| phb-1 29 30 |
|
OneToOne | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR313C 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHB1 29 30 32 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D16302g 29 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PHB3 29 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3157 29 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.15151 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0580500 29 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.24798 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6789 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08946 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | phb1 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4549 29 |
|
- Species where no ortholog for PHB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PHB Gene
- ENSEMBL:
- Gene Tree for PHB (if available)
- TreeFam:
- Gene Tree for PHB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PHB: view image
- Alliance of Genome Resources:
- Additional Orthologs for PHB
Paralogs for PHB Gene
(3) SIMAP similar genes for PHB Gene using alignment to 9 proteins:
- PHB_HUMAN
- A8K401_HUMAN
- B4DY47_HUMAN
- C9JW96_HUMAN
- C9JZ20_HUMAN
- D6RBK0_HUMAN
- E7ESE2_HUMAN
- E9PCW0_HUMAN
- Q6FHP5_HUMAN
Pseudogenes.org Pseudogenes for PHB Gene
- PGOHUM00000290655
- PGOHUM00000290736
- PGOHUM00000290886
- PGOHUM00000291326
- PGOHUM00000291337
- PGOHUM00000292128
- PGOHUM00000293285
- PGOHUM00000293863
- PGOHUM00000296066
- PGOHUM00000296323
- PGOHUM00000296343
- PGOHUM00000298762
- PGOHUM00000299543
- PGOHUM00000300437
- PGOHUM00000301989
- PGOHUM00000302296
- PGOHUM00000302299
- PGOHUM00000302809
- PGOHUM00000304355
- PGOHUM00000304795
- PGOHUM00000290265
Variants for PHB Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHB Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112294663 | Risk Factor: Breast cancer, susceptibility to | 49,404,263(-) |
G/A PHB:c.*729C>T |
THREE_PRIME_UTR | |
| rs121918372 | A breast cancer sample |
p.Arg105His |
|||
| rs121918373 | A breast cancer sample |
p.Val88Ala |
|||
| rs2233670 | Benign: not provided | 49,405,058(-) |
G/A NM_002634.4(PHB):c.753C>T (p.Leu251=) |
SYNONYMOUS_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
8.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHB Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene
Disorders for PHB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| chikungunya |
|
|
| igg4-related disease |
|
|
| human immunodeficiency virus type 1 |
|
|
| parkinson disease 4, autosomal dominant |
|
|
Search PHB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHB
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene
Publications for PHB Gene
- Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility. (PMID: 11377649) Jupe ER … Thompson LF (Lancet (London, England) 2001) 3 22 40 72
- The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T … Nakamura Y (Genomics 1993) 2 3 4 22
- Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N … Ulusoy AN (DNA and cell biology 2008) 3 22 40
- The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C … Hefler LA (European journal of obstetrics, gynecology, and reproductive biology 2008) 3 22 40
- Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A … Hamann U (BMC cancer 2008) 3 22 40
ExternalLinks
Products for PHB Gene
- Custom Antibody ServicesOriGene Antibodies for PHB
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PHB
- Search Origene for MassSpec and Protein Over-expression Lysates for PHB
- Origene Custom Protein Services for PHB
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- OriGene qPCR primer pairs for PHB
- OriGene qPCR primer pairs and template standards for PHB
- OriGene CRISPR knockouts for PHB
- MG220824
- MR220824
- MR220824L1
- MR220824L2
- MR220824L3
- MR220824L4
- RC201229
- RC201229L1
- RC201229L2
- RC201229L3
- RC201229L4
- RC236119
- RC237072
- RC237073
- RG201229
- RR205193
- RR205193L1
- RR205193L2
- RR205193L3
- RR205193L4
- MR220824L1V
- MR220824L2V
- MR220824L3V
- MR220824L4V
- RC201229L1V
- RC201229L2V
- RC201229L3V
- RC201229L4V
- RR205193L1V
- RR205193L2V
- RR205193L3V
- RR205193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PHB
- Sino Biological Human cDNA Clone for PHB
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PHB
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PHB
- Novus Biologicals proteins and lysates for PHB
- Novus Biologicals ELISA Kits for PHB
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PHB
- Abcam proteins for PHB
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PHB
- Taconic Biosciences Mouse Models for PHB
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PHB (AFLGC-PHB)
- VectorBuilder Custom and pre-made DNA vectors for PHB (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PHB (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PHB (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PHB CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PHB
- Addgene plasmids for PHB
- antibodies-online: Show 105 available Prohibitin Antibodies ranked by validation data
- Compare Top Prohibitin Antibodies
- Recommended
- 195 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 82 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 52 available Prohibitin Elisa Kits ranked by validation data
- Compare Top Prohibitin Elisa Kits
- Quality Products:
- ABIN1116655
- ABIN820339
- ABIN415254
- ABIN1571841
- ABIN5521376
- ABIN5668697
- ABIN510518
- ABIN5658085
- ABIN2538191
- ABIN2950649
- ABIN1571842
- ABIN1116654
- ABIN415814
- ABIN5521377
- ABIN5669870
- ABIN512015
- ABIN5658086
- ABIN6254427
- ABIN2538192
- ABIN2950650
- ABIN431722
- ABIN1571843
- ABIN1116656
- ABIN5521378
- ABIN5670529
- ABIN511792
- ABIN5658087
- ABIN2538193
- ABIN2950651
- ABIN6206661
- ABIN1565762
- ABIN6206654
- antibodies-online: Show 16 available Prohibitin Proteins ranked by validation data
- Compare Top Prohibitin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PHB
- Search Santa Cruz Biotechnology (SCBT) for PHB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PHB
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Sources for PHB Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135)