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This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18487222 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA | -- |
GO:0001850 | complement component C3a binding | IDA | 17070910 |
GO:0001851 | complement component C3b binding | IDA | 17070910 |
GO:0005515 | protein binding | IPI | 11302691 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 16130169 |
GO:0005654 | nucleoplasm | IDA | 12466959 |
GO:0005737 | cytoplasm | IDA | 16964284 |
GO:0005739 | mitochondrion | IEA,IDA | 24732013 |
GO:0005743 | mitochondrial inner membrane | TAS | 14500729 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
3 | Developmental Biology |
.51
|
|
4 | Cytokine Signaling in Immune system | ||
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 16964284 |
GO:0001649 | osteoblast differentiation | HDA | 16210410 |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 14500729 |
GO:0006851 | mitochondrial calcium ion transmembrane transport | TAS | -- |
GO:0007005 | mitochondrion organization | IMP | 17008324 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PHB 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PHB 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PHB 30 31 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | PHB 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PHB 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Phb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Phb 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
PHB 30 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | phb 30 |
|
||
MGC75944 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC64447 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | phb 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10205 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)37Cc 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009323 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | Y37E3.9 32 |
|
|
|
phb-1 30 31 |
|
OneToOne | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR313C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHB1 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D16302g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PHB3 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3157 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.15151 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0580500 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.24798 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6789 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08946 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | phb1 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4549 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
784359 | Benign: not provided | 49,405,058(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs112294663 | Risk Factor: Breast cancer, susceptibility to | 49,404,263(-) | G/A | THREE_PRIME_UTR_VARIANT | |
rs121918372 | A breast cancer sample | p.Arg105His | |||
rs121918373 | A breast cancer sample | p.Val88Ala |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
igg4-related disease |
|
|
chikungunya |
|
|
female breast cancer |
|
|
heinz body anemias |
|
|