Aliases for PHB Gene
External Ids for PHB Gene
Previous GeneCards Identifiers for PHB Gene
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PHB Gene
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are Integrated Breast Cancer Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding.
UniProtKB/Swiss-Prot for PHB Gene
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.