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This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript varia... See more...
Aliases for PHB Gene
Aliases for PHB Gene
External Ids for PHB Gene
- HGNC: 8912
- Entrez Gene: 5245
- Ensembl: ENSG00000167085
- OMIM: 176705
- UniProtKB: P35232
Previous GeneCards Identifiers for PHB Gene
- GC17M047192
- GC17M049961
- GC17M047823
- GC17M047956
- GC17M044836
- GC17M047481
- GC17M042846
Summaries for PHB Gene
-
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PHB Gene
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.
UniProtKB/Swiss-Prot Summary for PHB Gene
-
Regulates mitochondrial respiration activity and in aging (PubMed:11302691). In neurons, regulates the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Inhibits DNA synthesis (By similarity).
Additional gene information for PHB Gene
- HGNC(8912)
- Entrez Gene(5245)
- Ensembl(ENSG00000167085)
- OMIM(176705)
- UniProtKB(P35232)
- Open Targets Platform(ENSG00000167085)
- Monarch Initiative
- Search for PHB at DataMed
- Search for PHB at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PHB Gene
Genomics for PHB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PHB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PHB
- Top Transcription factor binding sites by QIAGEN in the PHB gene promoter:
-
- AML1a
- CP1A
- CUTL1
- GATA-3
- MyoD
- POU3F2
- RORalpha1
- SRY
- STAT3
- STAT5A
Genomic Locations for PHB Gene
Genomic Locations for PHB Gene
- chr17:49,404,048-49,414,905
- (GRCh38/hg38)
- Size:
- 10,858 bases
- Orientation:
- Minus strand
- chr17:47,481,414-47,492,246
- (GRCh37/hg19)
- Size:
- 10,833 bases
- Orientation:
- Minus strand
Genomic View for PHB Gene
Genes around PHB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by HGNC
- 17q21.33 by Entrez Gene
- 17q21.33 by Ensembl
PHB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHB Gene
Proteins for PHB Gene
-
Protein details for PHB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35232-PHB_HUMAN
- Recommended name:
- Prohibitin
- Protein Accession:
- P35232
- B4DY47
- Q4VBQ0
Protein attributes for PHB Gene
- Size:
- 272 amino acids
- Molecular mass:
- 29804 Da
- Quaternary structure:
-
- Interacts with PHB2 (PubMed:11302691, PubMed:20959514). Interacts with STOML2 (PubMed:21746876).
Protein Expression for PHB Gene
Post-translational modifications for PHB Gene
Other Protein References for PHB Gene
Antibody Products
- G Biosciences Immunotag™ Prohibitin Antibody and Immunotag™ PHB Antibody
- NSJ Bioreagents Prohibitin Antibody (PHB1) and Prohibitin Antibody / PHB (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for PHB
- Novus Biologicals Antibodies for PHB
-
Abcam antibodies for PHB
- Invitrogen Antibodies for PHB (AFLGC-PHB)
- antibodies-online: Show 105 available Prohibitin Antibodies ranked by validation data
- Compare Top Prohibitin Antibodies
-
Recommended
- 195 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 82 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PHB
- Sino Biological Antibodies for PHB
Protein Products
-
OriGene Purified Proteins for PHB
- Search Origene for MassSpec and Protein Over-expression Lysates for PHB
- Origene Custom Protein Services for PHB
- ProSpec Recombinant Proteins for PHB
-
Abcam proteins for PHB
Assay Products
- G Biosciences Immunotag™ Human PHB (Prohibitin) ELISA
- Novus Biologicals ELISA Kits for PHB
- antibodies-online: Show 52 available Prohibitin Elisa Kits ranked by validation data
- Compare Top Prohibitin Elisa Kits
-
Quality Products:
- ABIN1116655
- ABIN820339
- ABIN415254
- ABIN1571841
- ABIN5521376
- ABIN5668697
- ABIN510518
- ABIN5658085
- ABIN2538191
- ABIN2950649
- ABIN1571842
- ABIN1116654
- ABIN415814
- ABIN5521377
- ABIN5669870
- ABIN512015
- ABIN5658086
- ABIN6254427
- ABIN2538192
- ABIN2950650
- ABIN431722
- ABIN1571843
- ABIN1116656
- ABIN5521378
- ABIN5670529
- ABIN511792
- ABIN5658087
- ABIN2538193
- ABIN2950651
- ABIN6206661
- ABIN1565762
- ABIN6206654
-
Signalway ELISA kits for PHB
No data available for DME Specific Peptides for PHB Gene
Domains & Families for PHB Gene
Gene Families for PHB Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PHB Gene
- InterPro:
- Blocks:
-
- Prohibitin signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PHB Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA (A8K401_HUMAN)
- cDNA FLJ51562, highly similar to Prohibitin (B4DY47_HUMAN)
- Prohibitin (PHB_HUMAN)
- PHB protein (Q6FHP5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35232- Family:
-
- Belongs to the prohibitin family.
Function for PHB Gene
Molecular function for PHB Gene
- UniProtKB/Swiss-Prot Function:
- Regulates mitochondrial respiration activity and in aging (PubMed:11302691). In neurons, regulates the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Inhibits DNA synthesis (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
- GENATLAS Biochemistry:
- prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function
Phenotypes From GWAS Catalog for PHB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18487222 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA | -- |
| GO:0001850 | complement component C3a binding | IDA | 17070910 |
| GO:0001851 | complement component C3b binding | IDA | 17070910 |
| GO:0005515 | protein binding | IPI | 11302691 |
Phenotypes for PHB Gene
- MGI mutant phenotypes for PHB:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for PHB:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Increased G1 DNA content
- shRNA abundance <= 25%
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- G0/1 arrest
- Decreased viability with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, decreased peripheral FA formation
Animal Models for PHB Gene
- MGI Knock Outs for PHB:
-
- Phb Phb<tm1.2Bwo>
Animal Model Products
-
Taconic Biosciences Mouse Models for PHB
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PHB - Select products 50% OFF >
- * PHB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
miRNA for PHB Gene
- miRTarBase miRNAs that target PHB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Clone Products
- Applied Biological Materials (abm): Clones for PHB - Select products 50% OFF >
- * PHB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG220824
- MR220824
- MR220824L1
- MR220824L2
- MR220824L3
- MR220824L4
- RC201229
- RC201229L1
- RC201229L2
- RC201229L3
- RC201229L4
- RC236119
- RC237072
- RC237073
- RG201229
- RR205193
- RR205193L1
- RR205193L2
- RR205193L3
- RR205193L4
- MR220824L1V
- MR220824L2V
- MR220824L3V
- MR220824L4V
- RC201229L1V
- RC201229L2V
- RC201229L3V
- RC201229L4V
- RR205193L1V
- RR205193L2V
- RR205193L3V
- RR205193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PHB
- Addgene plasmids for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PHB Gene
Localization for PHB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene
- Mitochondrion inner membrane. Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| endosome | 5 |
| extracellular | 4 |
| cytosol | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Mitochondria (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005654 | nucleoplasm | IDA | 12466959 |
| GO:0005737 | cytoplasm | IDA | 16964284 |
| GO:0005739 | mitochondrion | IEA,IDA | 24732013 |
| GO:0005743 | mitochondrial inner membrane | TAS | 14500729 |
Pathways & Interactions for PHB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for PHB Gene
1 BioSystems pathway for PHB Gene
53 Reactome pathways for PHB Gene
1 R&D Systems pathway for PHB Gene
1 Cell Signaling Technology pathway for PHB Gene
Interacting Proteins for PHB Gene
Selected Interacting proteins:
P35232-PHB_HUMAN
ENSP00000479488
for PHB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PHB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 16964284 |
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 14500729 |
| GO:0006851 | mitochondrial calcium ion transmembrane transport | TAS | -- |
| GO:0007005 | mitochondrion organization | IMP | 17008324 |
No data available for SIGNOR curated interactions for PHB Gene
Transcripts for PHB Gene
mRNA/cDNA for PHB Gene
- 4 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300408 1832 nts (view in UCSC)
- ENST00000393345 847 nts (view in UCSC)
- ENST00000419140 907 nts (view in UCSC)
- ENST00000434917 534 nts (view in UCSC)
- ENST00000446735 732 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PHB - Select products 50% OFF >
- * PHB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PHB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Clone Products
- Applied Biological Materials (abm): Clones for PHB - Select products 50% OFF >
- * PHB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG220824
- MR220824
- MR220824L1
- MR220824L2
- MR220824L3
- MR220824L4
- RC201229
- RC201229L1
- RC201229L2
- RC201229L3
- RC201229L4
- RC236119
- RC237072
- RC237073
- RG201229
- RR205193
- RR205193L1
- RR205193L2
- RR205193L3
- RR205193L4
- MR220824L1V
- MR220824L2V
- MR220824L3V
- MR220824L4V
- RC201229L1V
- RC201229L2V
- RC201229L3V
- RC201229L4V
- RR205193L1V
- RR205193L2V
- RR205193L3V
- RR205193L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PHB
- Addgene plasmids for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for PHB Gene
- GeneLoc Exon Structure for
- PHB
Expression for PHB Gene
This gene is overexpressed in Nasal epithelium (25.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PHB Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PHB
SOURCE GeneReport for Unigene cluster for PHB Gene:
Hs.514303mRNA Expression by UniProt/SwissProt for PHB Gene:
P35232-PHB_HUMAN
Tissue specificity:
Widely expressed in different tissues.
Evidence on tissue expression from TISSUES for PHB Gene
- Nervous system(5)
- Liver(4.9)
- Lung(4.8)
- Muscle(4.7)
- Skin(4.4)
- Intestine(4.3)
- Kidney(3.8)
- Pancreas(3.7)
- Eye(3.6)
- Heart(3.5)
- Stomach(3)
- Blood(2.8)
- Lymph node(2.7)
- Bone(2.6)
- Bone marrow(2.5)
- Thyroid gland(2.5)
- Spleen(2.5)
- Adrenal gland(2.4)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for PHB
-
OriGene qPCR primer pairs and template standards for PHB
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene
Orthologs for PHB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PHB 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PHB 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PHB 30 31 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | PHB 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PHB 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Phb 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Phb 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| PHB 30 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | phb 30 |
|
||
| MGC75944 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64447 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | phb 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10205 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)37Cc 30 31 32 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009323 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | Y37E3.9 32 |
|
|
|
| phb-1 30 31 |
|
OneToOne | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR313C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHB1 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D16302g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PHB3 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3157 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.15151 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0580500 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.24798 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6789 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08946 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | phb1 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4549 30 |
|
- Species where no ortholog for PHB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PHB Gene
- ENSEMBL:
- Gene Tree for PHB (if available)
- TreeFam:
- Gene Tree for PHB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PHB: view image
Paralogs for PHB Gene
(3) SIMAP similar genes for PHB Gene using alignment to 9 proteins:
- PHB_HUMAN
- A8K401_HUMAN
- B4DY47_HUMAN
- C9JW96_HUMAN
- C9JZ20_HUMAN
- D6RBK0_HUMAN
- E7ESE2_HUMAN
- E9PCW0_HUMAN
- Q6FHP5_HUMAN
Pseudogenes.org Pseudogenes for PHB Gene
- PGOHUM00000290655
- PGOHUM00000290736
- PGOHUM00000290886
- PGOHUM00000291326
- PGOHUM00000291337
- PGOHUM00000292128
- PGOHUM00000293285
- PGOHUM00000293863
- PGOHUM00000296066
- PGOHUM00000296323
- PGOHUM00000296343
- PGOHUM00000298762
- PGOHUM00000299543
- PGOHUM00000300437
- PGOHUM00000301989
- PGOHUM00000302296
- PGOHUM00000302299
- PGOHUM00000302809
- PGOHUM00000304355
- PGOHUM00000304795
- PGOHUM00000290265
Variants for PHB Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PHB Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 784359 | Benign: not provided | 49,405,058(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| rs112294663 | Risk Factor: Breast cancer, susceptibility to | 49,404,263(-) | G/A | THREE_PRIME_UTR_VARIANT | |
| rs121918372 | A breast cancer sample | p.Arg105His | |||
| rs121918373 | A breast cancer sample | p.Val88Ala |
Residual Variation Intolerance Score:
22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
8.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene
Disorders for PHB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| igg4-related disease |
|
|
| chikungunya |
|
|
| female breast cancer |
|
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| heinz body anemias |
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Search PHB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene
Publications for PHB Gene
- The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T … Nakamura Y (Genomics 1993) 2 3 4 23
- Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N … Ulusoy AN (DNA and cell biology 2008) 3 23 41
- Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A … Hamann U (BMC cancer 2008) 3 23 41
- The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C … Hefler LA (European journal of obstetrics, gynecology, and reproductive biology 2008) 3 23 41
- The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PMID: 17004108) Jakubowska A … Hamann U (Breast cancer research and treatment 2007) 3 23 41
ExternalLinks
Products for PHB Gene
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- antibodies-online: Show 105 available Prohibitin Antibodies ranked by validation data
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- Recommended
- 195 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 82 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
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- antibodies-online: Show 52 available Prohibitin Elisa Kits ranked by validation data
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- antibodies-online: Show 16 available Prohibitin Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PHB
- Search Santa Cruz Biotechnology (SCBT) for PHB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PHB
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PHB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PHB
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PHB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PHB
Sources for PHB Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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