Aliases for PHB Gene
External Ids for PHB Gene
Previous GeneCards Identifiers for PHB Gene
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PHB Gene
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PHB2.
UniProtKB/Swiss-Prot Summary for PHB Gene
Regulates mitochondrial respiration activity and in aging (PubMed:11302691). In neurons, regulates the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Inhibits DNA synthesis (By similarity).