Aliases for PHB Gene
Aliases for PHB Gene
External Ids for PHB Gene
- HGNC: 8912
- Entrez Gene: 5245
- Ensembl: ENSG00000167085
- OMIM: 176705
- UniProtKB: P35232
Previous GeneCards Identifiers for PHB Gene
- GC17M047192
- GC17M049961
- GC17M047823
- GC17M047956
- GC17M044836
- GC17M047481
- GC17M042846
Summaries for PHB Gene
-
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PHB Gene
PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Chikungunya. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding.
UniProtKB/Swiss-Prot for PHB Gene
-
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Additional gene information for PHB Gene
- Monarch Initiative
- Search for PHB at DataMed
- Search for PHB at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB Gene
Genomics for PHB Gene
GeneHancer (GH) Regulatory Elements for PHB Gene
Promoters and enhancers for PHB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PHB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PHB Gene
Genomic Locations for PHB Gene
- chr17:49,404,048-49,414,905
- (GRCh38/hg38)
- Size:
- 10,858 bases
- Orientation:
- Minus strand
- chr17:47,481,414-47,492,246
- (GRCh37/hg19)
Genomic View for PHB Gene
Genes around PHB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by Ensembl
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC
PHB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PHB Gene
Proteins for PHB Gene
-
Protein details for PHB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35232-PHB_HUMAN
- Recommended name:
- Prohibitin
- Protein Accession:
- P35232
- B4DY47
- Q4VBQ0
Protein attributes for PHB Gene
- Size:
- 272 amino acids
- Molecular mass:
- 29804 Da
- Quaternary structure:
-
- Interacts with PHB2. Interacts with STOML2.
Protein Expression for PHB Gene
Post-translational modifications for PHB Gene
No Post-translational modifications
Other Protein References for PHB Gene
Antibody Products
- R&D Systems Antibodies for PHB (Prohibitin)
- Cell Signaling Technology (CST) Antibodies for PHB (PHB)
-
Custom Antibody ServicesOriGene Antibodies for PHB
- Novus Biologicals Antibodies for PHB
-
Abcam antibodies for PHB
-
Cloud-Clone Corp. Antibodies for PHB
- Invitrogen Antibodies for PHB
- antibodies-online: Search results for 222 available Prohibitin Antibodies ranked by validation data
- Compare Top Prohibitin Antibodies
-
Recommended
- 2 IHC (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 69 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 69 WB Antibodies (anti-mouse)
- 1 EIA Antibody (anti-human)
- 2 RIA Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 173 WB Antibodies (anti-human)
- GeneTex PHB antibody for PHB
-
Santa Cruz Biotechnology (SCBT) Antibodies for PHB
Protein Products
-
OriGene Purified Proteins for PHB
- Search Origene for MassSpec and Protein Over-expression Lysates for PHB
- Origene Custom Protein Services for PHB
- ProSpec Recombinant Proteins for PHB
-
Cloud-Clone Corp. Proteins for PHB
- Search GeneTex for Proteins for PHB
-
Abcam proteins for PHB
Assay Products
-
Cloud-Clone Corp. Assay Kits for PHB
No data available for DME Specific Peptides for PHB Gene
Domains & Families for PHB Gene
Gene Families for PHB Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PHB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PHB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35232- Family:
-
- Belongs to the prohibitin family.
Function for PHB Gene
Molecular function for PHB Gene
- GENATLAS Biochemistry:
- prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function
- UniProtKB/Swiss-Prot Function:
- Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
- UniProtKB/Swiss-Prot Induction:
- Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
Phenotypes From GWAS Catalog for PHB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0001850 | complement component C3a binding | IDA | 17070910 |
| GO:0001851 | complement component C3b binding | IDA | 17070910 |
| GO:0005515 | protein binding | IPI | 11302691 |
| GO:0008022 | protein C-terminus binding | IPI | 19906925 |
Phenotypes for PHB Gene
- MGI mutant phenotypes for PHB:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for PHB:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased shRNA abundance (Z-score > 2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased POU5F1-GFP protein expression
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased viability of wild-type and TP53 knockout cells
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased viability
- Decreased viability with paclitaxel
Animal Models for PHB Gene
- MGI Knock Outs for PHB:
-
- Phb tm1.2Bwo
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PHB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PHB gene
- Search ViGene Biosciences for PHB
CRISPR Products
-
OriGene CRISPR knockouts for PHB
- genomics-online: gRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- Applied Biological Materials CRISPR for PHB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
- GenScript: Design CRISPR guide RNA sequences for PHB
miRNA for PHB Gene
- miRTarBase miRNAs that target PHB
miRNA Products
- Search ViGene Biosciences for PHB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- genomics-online: shRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PHB gene
Clone Products
- Sino Biological Human cDNA Clone for PHB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PHB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PHB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PHB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PHB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PHB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHB Gene
Localization for PHB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Mitochondria (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 16130169 |
| GO:0005654 | nucleoplasm | IDA | 12466959 |
| GO:0005737 | cytoplasm | IDA | 16964284 |
| GO:0005739 | mitochondrion | IEA,IDA | 24732013 |
| GO:0005743 | mitochondrial inner membrane | TAS | 14500729 |
Pathways & Interactions for PHB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Signaling by moderate kinase activity BRAF mutants | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for PHB Gene
1 Cell Signaling Technology pathway for PHB Gene
1 BioSystems pathway for PHB Gene
53 Reactome pathways for PHB Gene
1 R&D Systems pathway for PHB Gene
Interacting Proteins for PHB Gene
Selected Interacting proteins:
P35232-PHB_HUMAN
ENSP00000300408
for PHB Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 16964284 |
| GO:0001649 | osteoblast differentiation | HDA,IDA | 16210410 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 14500729 |
| GO:0006851 | mitochondrial calcium ion transmembrane transport | TAS | -- |
| GO:0007005 | mitochondrion organization | IMP | 17008324 |
No data available for SIGNOR curated interactions for PHB Gene
Transcripts for PHB Gene
mRNA/cDNA for PHB Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1004) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PHB
- genomics-online: gRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- Applied Biological Materials CRISPR for PHB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PHB
- GenScript: Design CRISPR guide RNA sequences for PHB
miRNA Products
- Search ViGene Biosciences for PHB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PHB
- Browse OriGene Inhibitory RNA Products For PHB
- genomics-online: shRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PHB gene
Clone Products
- Sino Biological Human cDNA Clone for PHB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PHB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PHB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - |
Expression for PHB Gene
This gene is overexpressed in Nasal epithelium (25.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PHB Gene:
PHBSOURCE GeneReport for Unigene cluster for PHB Gene:
Hs.514303mRNA Expression by UniProt/SwissProt for PHB Gene:
P35232-PHB_HUMAN
Tissue specificity:
Widely expressed in different tissues.
Evidence on tissue expression from TISSUES for PHB Gene
- Liver(4.9)
- Nervous system(4.9)
- Lung(4.8)
- Muscle(4.7)
- Intestine(4.1)
- Skin(4.1)
- Kidney(3.4)
- Eye(3.3)
- Pancreas(3.3)
- Heart(2.9)
- Stomach(2.5)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for PHB
-
OriGene qPCR primer pairs and template standards for PHB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene
Orthologs for PHB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PHB 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PHB 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PHB 33 34 34 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | PHB 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PHB 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Phb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Phb 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| PHB 33 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | phb 33 |
|
||
| MGC75944 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64447 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | phb 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10205 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | l(2)37Cc 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009323 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y37E3.9 35 |
|
|
|
| phb-1 33 34 |
|
||||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR313C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHB1 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D16302g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PHB3 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.15151 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3157 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0580500 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.24798 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6789 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08946 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | phb1 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4549 33 |
|
- Species where no ortholog for PHB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for PHB Gene
(3) SIMAP similar genes for PHB Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for PHB Gene
- PGOHUM00000290655
- PGOHUM00000290736
- PGOHUM00000290886
- PGOHUM00000291326
- PGOHUM00000291337
- PGOHUM00000292128
- PGOHUM00000293285
- PGOHUM00000293863
- PGOHUM00000296066
- PGOHUM00000296323
- PGOHUM00000296343
- PGOHUM00000298762
- PGOHUM00000299543
- PGOHUM00000300437
- PGOHUM00000301989
- PGOHUM00000302296
- PGOHUM00000302299
- PGOHUM00000302809
- PGOHUM00000304355
- PGOHUM00000304795
- PGOHUM00000290265
No data available for Paralogs for PHB Gene
Variants for PHB Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112294663 | risk-factor, Breast cancer, susceptibility to | 49,404,263(-) | G/A/C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs121918372 | A breast cancer sample | 49,409,410(-) | C/T | coding_sequence_variant, missense_variant | |
| rs121918373 | A breast cancer sample | 49,409,461(-) | A/G | coding_sequence_variant, missense_variant | |
| rs1001162524 | -- | 49,407,624(-) | C/T | intron_variant | |
| rs1001167734 | -- | 49,410,822(-) | C/G/T | intron_variant |
Residual Variation Intolerance Score:
22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
8.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PHB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene
Disorders for PHB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| chikungunya |
|
|
| igg4-related disease |
|
|
| ovarian epithelial cancer |
|
|
| mikulicz disease |
|
|
Search PHB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PHB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene
Publications for PHB Gene
- The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T … Nakamura Y (Genomics 1993) 2 3 4 22 58
- Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A … Hamann U (BMC cancer 2008) 3 22 44 58
- Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N … Ulusoy AN (DNA and cell biology 2008) 3 22 44 58
- The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C … Hefler LA (European journal of obstetrics, gynecology, and reproductive biology 2008) 3 22 44 58
- The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PMID: 17004108) Jakubowska A … Hamann U (Breast cancer research and treatment 2007) 3 22 44 58
Products for PHB Gene
- R&D Systems Antibodies for PHB (Prohibitin)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for PHB
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- OriGene Purified Proteins for PHB
- Search Origene for MassSpec and Protein Over-expression Lysates for PHB
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- Browse OriGene Inhibitory RNA Products For PHB
- OriGene qPCR primer pairs and template standards for PHB
- OriGene qPCR primer pairs for PHB
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- OriGene ORF clones in human for PHB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Cell Signaling Technology (CST) Antibodies for PHB (PHB)
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- Sino Biological Human cDNA Clone for PHB
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for PHB
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for PHB
- Cloud-Clone Corp. Antibodies for PHB
- Cloud-Clone Corp. Proteins for PHB
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PHB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PHB
- VectorBuilder custom plasmid, inducible vectors for PHB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PHB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 222 available Prohibitin Antibodies ranked by validation data
- Compare Top Prohibitin Antibodies
- Recommended
- 173 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 69 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 40 available Prohibitin Elisa Kits ranked by validation data
- Compare Top Prohibitin Elisa Kits
- antibodies-online: Search results for 16 available Prohibitin Proteins ranked by validation data
- Compare Top Prohibitin Proteins
- GeneTex PHB antibody for PHB
- Search GeneTex for Proteins for PHB
- ViGene Biosciences adenoviral particle packaged cDNA for PHB gene
- ViGene Biosciences lentiviral particle packaged cDNA for PHB gene
- ViGene Biosciences ready-to-package AAV shRNAs for PHB gene
- Search ViGene Biosciences for PHB
- Santa Cruz Biotechnology (SCBT) Antibodies for PHB
- Search Santa Cruz Biotechnology (SCBT) for PHB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PHB
- genomics-online: cdna clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- orf clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- genomics-online: gRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- genomics-online: primer clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
- genomics-online: shRNA clones - Search results for 148 available Prohibitin gene related products
- Overview of 148 available Prohibitin gene related products
Sources for PHB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew