Aliases for PHAX Gene
- Phosphorylated Adaptor For RNA Export 2 3 5
- RNA U, Small Nuclear RNA Export Adaptor (Phosphorylation Regulated) 2 3
- RNA U Small Nuclear RNA Export Adapter Protein 3 4
- Phosphorylated Adapter RNA Export Protein 3 4
- RNUXA 3 4
- RNA U, Small Nuclear RNA Export Adapter (Phosphorylation Regulated) 3
- FLJ13193 2
- PHAX 5
External Ids for PHAX Gene
Previous HGNC Symbols for PHAX Gene
Previous GeneCards Identifiers for PHAX Gene
GeneCards Summary for PHAX Gene
PHAX (Phosphorylated Adaptor For RNA Export) is a Protein Coding gene. Diseases associated with PHAX include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Retinitis Pigmentosa 57. Among its related pathways are Transport of the SLBP independent Mature mRNA and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and toxic substance binding.
UniProtKB/Swiss-Prot Summary for PHAX Gene
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.