Aliases for PGRMC2 Gene
External Ids for PGRMC2 Gene
Previous GeneCards Identifiers for PGRMC2 Gene
GeneCards Summary for PGRMC2 Gene
PGRMC2 (Progesterone Receptor Membrane Component 2) is a Protein Coding gene. Diseases associated with PGRMC2 include Arthrogryposis, Distal, Type 6 and Arthrogryposis, Distal, Type 7. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC1.
UniProtKB/Swiss-Prot Summary for PGRMC2 Gene
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).