Aliases for PGRMC1 Gene
External Ids for PGRMC1 Gene
Previous GeneCards Identifiers for PGRMC1 Gene
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
GeneCards Summary for PGRMC1 Gene
PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Preterm Premature Rupture Of The Membranes and Placental Choriocarcinoma. Among its related pathways are Innate Immune System and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.
UniProtKB/Swiss-Prot Summary for PGRMC1 Gene
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).