This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010] See more...

Aliases for PGRMC1 Gene

Aliases for PGRMC1 Gene

  • Progesterone Receptor Membrane Component 1 2 3 5
  • Membrane-Associated Progesterone Receptor Component 1 3 4
  • HPR6.6 3 4
  • Dap1 3 4
  • MPR 3 4
  • IZA 3 4
  • Progesterone Binding Protein 3
  • PGRMC 4

External Ids for PGRMC1 Gene

Previous GeneCards Identifiers for PGRMC1 Gene

  • GC0XP113188
  • GC0XP115355
  • GC0XP116345
  • GC0XP117124
  • GC0XP118152
  • GC0XP118254
  • GC0XP118370
  • GC0XP107864

Summaries for PGRMC1 Gene

Entrez Gene Summary for PGRMC1 Gene

  • This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

GeneCards Summary for PGRMC1 Gene

PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Preterm Premature Rupture Of The Membranes and Placental Choriocarcinoma. Among its related pathways are Innate Immune System and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot Summary for PGRMC1 Gene

  • Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Gene Wiki entry for PGRMC1 Gene

Additional gene information for PGRMC1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGRMC1 Gene

Genomics for PGRMC1 Gene

GeneHancer (GH) Regulatory Elements for PGRMC1 Gene

Promoters and enhancers for PGRMC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119234 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 505.7 +0.8 756 4.8 NRF1 USF1 POLR2G GTF2E2 PHF8 ZFX ZIC2 POLR2A ZBTB10 ZBTB26 PGRMC1 UPF3B FR772910-011
GH0XJ119674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 +448.5 448466 20.2 FOXK2 HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G SP1 SEPTIN6 NKAPP1 UPF3B NKRF MIR766 CXorf56 LINC01402 EEF1A1P30 SLC25A5-AS1 CUL4B
GH0XJ119187 Enhancer 0.6 Ensembl 11.8 -48.8 -48816 0.5 RBM25 FOXA2 JUND IRF1 FOXA1 HNF4A FOS HLF NFYC YY1 ARL5AP1 lnc-KIAA1210-3 piR-31926-042 KIAA1210 PGRMC1 lnc-PGRMC1-2 RF00017-8640
GH0XJ119239 Enhancer 0.5 ENCODE 5.8 +4.3 4295 1.8 FOS ZNF513 NR2F1 NR2F6 NFE2L2 HNF1A PKNOX1 YY1 PGRMC1 FR772910-011
GH0XJ119317 Enhancer 0.2 Ensembl 11.3 +81.5 81456 0.2 piR-37567-245 lnc-PGRMC1-3 piR-30444-356 PGRMC1 ENSG00000226661 SLC25A43 LOC101928336
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGRMC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGRMC1

Top Transcription factor binding sites by QIAGEN in the PGRMC1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myb
  • C/EBPbeta
  • HEN1
  • HNF-4alpha1
  • HNF-4alpha2
  • USF-1
  • USF1

Genomic Locations for PGRMC1 Gene

Genomic Locations for PGRMC1 Gene
chrX:119,236,245-119,244,466
(GRCh38/hg38)
Size:
8,222 bases
Orientation:
Plus strand
chrX:118,370,211-118,378,429
(GRCh37/hg19)
Size:
8,219 bases
Orientation:
Plus strand

Genomic View for PGRMC1 Gene

Genes around PGRMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC1 Gene

Proteins for PGRMC1 Gene

  • Protein details for PGRMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00264-PGRC1_HUMAN
    Recommended name:
    Membrane-associated progesterone receptor component 1
    Protein Accession:
    O00264
    Secondary Accessions:
    • B7Z1L3
    • Q9UGJ9

    Protein attributes for PGRMC1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21671 Da
    Quaternary structure:
    • Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
    Miscellaneous:
    • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

    Three dimensional structures from OCA and Proteopedia for PGRMC1 Gene

    Alternative splice isoforms for PGRMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGRMC1 Gene

Post-translational modifications for PGRMC1 Gene

  • Ubiquitination at Lys96, Lys102, Lys105, and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for PGRMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGRMC1 Gene

Domains & Families for PGRMC1 Gene

Gene Families for PGRMC1 Gene

Protein Domains for PGRMC1 Gene

Blocks:
  • Cytochrome b5
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PGRMC1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50115, moderately similar to Membrane-associated progesterone receptor component 1 (B7Z1L3_HUMAN)
  • Membrane-associated progesterone receptor component 1 (PGRC1_HUMAN)
  • cDNA, FLJ94602, Homo sapiens progesterone receptor membrane component 1 (PGRMC1),mRNA (Q6IB11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00264

UniProtKB/Swiss-Prot:

PGRC1_HUMAN :
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
Domain:
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC1: view

Function for PGRMC1 Gene

Molecular function for PGRMC1 Gene

UniProtKB/Swiss-Prot Function:
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Gene Ontology (GO) - Molecular Function for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding TAS 26871627
GO:0005496 steroid binding TAS,IEA --
GO:0005515 protein binding IPI 21081644
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PGRMC1: view
genes like me logo Genes that share phenotypes with PGRMC1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC1 Gene

Localization for PGRMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC1 Gene

Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGRMC1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 25390692
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 25390692
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PGRMC1: view

Pathways & Interactions for PGRMC1 Gene

genes like me logo Genes that share pathways with PGRMC1: view

Pathways by source for PGRMC1 Gene

3 Reactome pathways for PGRMC1 Gene
1 Cell Signaling Technology pathway for PGRMC1 Gene

Gene Ontology (GO) - Biological Process for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PGRMC1: view

No data available for SIGNOR curated interactions for PGRMC1 Gene

Drugs & Compounds for PGRMC1 Gene

(12) Drugs for PGRMC1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator, Agonist, Inhibition, Pore Blocker Endogenous progesterone receptor agonist 721
Dextromethorphan Approved Pharma Target, binder 164
Nortriptyline Approved Pharma Antagonist, Pore Blocker, Target, binder 53
Sertraline Approved Pharma Inhibition, Inhibitor, Target, inhibitor, binder 332
Iron Approved, Experimental Pharma 1496

(1) Additional Compounds for PGRMC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PGRMC1: view

Transcripts for PGRMC1 Gene

mRNA/cDNA for PGRMC1 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PGRMC1 Gene

GeneLoc Exon Structure for
PGRMC1

Expression for PGRMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGRMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC1 Gene

This gene is overexpressed in Nasal epithelium (13.6), Bone (8.7), and Fetal testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGRMC1 Gene



Protein tissue co-expression partners for PGRMC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGRMC1

SOURCE GeneReport for Unigene cluster for PGRMC1 Gene:

Hs.90061

mRNA Expression by UniProt/SwissProt for PGRMC1 Gene:

O00264-PGRC1_HUMAN
Tissue specificity: Widely expressed, with highest expression in liver and kidney.

Evidence on tissue expression from TISSUES for PGRMC1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.4)
  • Intestine(2.9)
  • Kidney(2.9)
  • Lung(2.7)
  • Eye(2.6)
  • Skin(2.6)
  • Heart(2.5)
  • Muscle(2.2)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Adrenal gland(2)
  • Bone(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PGRMC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGRMC1 Gene

Orthologs for PGRMC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGRMC1 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGRMC1 31 30
  • 95.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PGRMC1 31 30
  • 92.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pgrmc1 17 31 30
  • 91.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PGRMC1 31
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgrmc1 30
  • 87.7 (n)
oppossum
(Monodelphis domestica)
Mammalia PGRMC1 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGRMC1 31 30
  • 75.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGRMC1 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc1 30
  • 69.41 (n)
Str.1525 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5375 30
zebrafish
(Danio rerio)
Actinopterygii pgrmc1 31 30
  • 65.48 (n)
OneToOne
Dr.26789 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.28 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000767 30
  • 62.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta MSBP 31 30
  • 54.41 (n)
OneToMany
CG9066 32
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea vem-1 31 30
  • 51.24 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL106W 30
  • 52.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09757g 30
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 33 31 30
  • 48.39 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07286 30
  • 54.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dap1 30
  • 50.68 (n)
Species where no ortholog for PGRMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC1 Gene

ENSEMBL:
Gene Tree for PGRMC1 (if available)
TreeFam:
Gene Tree for PGRMC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGRMC1: view image

Paralogs for PGRMC1 Gene

Paralogs for PGRMC1 Gene

(2) SIMAP similar genes for PGRMC1 Gene using alignment to 3 proteins:

  • PGRC1_HUMAN
  • B7Z1L3_HUMAN
  • Q6IB11_HUMAN

Pseudogenes.org Pseudogenes for PGRMC1 Gene

genes like me logo Genes that share paralogs with PGRMC1: view

Variants for PGRMC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGRMC1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
739704 Benign: not provided 119,236,507(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PGRMC1 Gene

Variation tolerance for PGRMC1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGRMC1 Gene

Human Gene Mutation Database (HGMD)
PGRMC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGRMC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGRMC1 Gene

Disorders for PGRMC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PGRMC1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PGRMC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PGRMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGRMC1 Gene

Publications for PGRMC1 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D … Falkenstein E (Biological chemistry 1998) 2 3 4 23 54
  2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PMID: 11697142) Bernauer S … Falkenstein E (DNA sequence : the journal of DNA sequencing and mapping 2001) 3 4 23 54
  3. Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1. (PMID: 28007569) Pati ML … Abate C (Pharmacological research 2017) 3 4 54
  4. Spectroscopic and mutagenesis studies of human PGRMC1. (PMID: 25675345) Kaluka D … Yeh SR (Biochemistry 2015) 3 4 54
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 41 54

Products for PGRMC1 Gene

Sources for PGRMC1 Gene