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Aliases for PGRMC1 Gene

Aliases for PGRMC1 Gene

  • Progesterone Receptor Membrane Component 1 2 3 5
  • HPR6.6 3 4
  • Dap1 3 4
  • MPR 3 4
  • IZA 3 4
  • Membrane-Associated Progesterone Receptor Component 1 3
  • Progesterone Binding Protein 3
  • PGRMC 4

External Ids for PGRMC1 Gene

Previous GeneCards Identifiers for PGRMC1 Gene

  • GC0XP113188
  • GC0XP115355
  • GC0XP116345
  • GC0XP117124
  • GC0XP118152
  • GC0XP118254
  • GC0XP118370
  • GC0XP107864

Summaries for PGRMC1 Gene

Entrez Gene Summary for PGRMC1 Gene

  • This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

GeneCards Summary for PGRMC1 Gene

PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Supraglottis Cancer and Patulous Eustachian Tube. Among its related pathways are Innate Immune System and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot for PGRMC1 Gene

  • Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Gene Wiki entry for PGRMC1 Gene

Additional gene information for PGRMC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC1 Gene

Genomics for PGRMC1 Gene

GeneHancer (GH) Regulatory Elements for PGRMC1 Gene

Promoters and enhancers for PGRMC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119234 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.8 +0.8 762 4.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PGRMC1 UPF3B NKAP EEF1A1P30 AKAP17BP
GH0XJ119674 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 +448.5 448459 20.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B FEZF1 IRF4 YY1 POLR2B SEPT6 NKAPP1 EEF1A1P30 CUL4B NKAP NKRF UPF3B MIR766 CXorf56 SLC25A5-AS1
GH0XJ119239 Enhancer 0.4 ENCODE 5.9 +4.3 4295 1.8 HNF1A PKNOX1 YY1 PGRMC1 AKAP17BP
GH0XJ119240 Enhancer 0.3 ENCODE 0.7 +3.0 3012 0 YY1 PGRMC1 AKAP17BP
GH0XJ119228 Enhancer 0.2 ENCODE 0.4 -7.5 -7532 0.2 PGRMC1 NUDT19P1 GC0XM119222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGRMC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGRMC1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • HEN1
  • USF-1
  • USF1
  • HNF-4alpha2
  • HNF-4alpha1
  • C/EBPbeta
  • c-Myb

Genomic Locations for PGRMC1 Gene

Genomic Locations for PGRMC1 Gene
8,222 bases
Plus strand
8,219 bases
Plus strand

Genomic View for PGRMC1 Gene

Genes around PGRMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC1 Gene

Proteins for PGRMC1 Gene

  • Protein details for PGRMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated progesterone receptor component 1
    Protein Accession:
    Secondary Accessions:
    • B7Z1L3
    • Q9UGJ9

    Protein attributes for PGRMC1 Gene

    195 amino acids
    Molecular mass:
    21671 Da
    Quaternary structure:
    • Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
    • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

    Three dimensional structures from OCA and Proteopedia for PGRMC1 Gene

    Alternative splice isoforms for PGRMC1 Gene


neXtProt entry for PGRMC1 Gene

Post-translational modifications for PGRMC1 Gene

  • Ubiquitination at isoforms=132, Lys105, isoforms=2102, and isoforms=296
  • Modification sites at PhosphoSitePlus

Other Protein References for PGRMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGRMC1 Gene

Domains & Families for PGRMC1 Gene

Gene Families for PGRMC1 Gene

Protein Domains for PGRMC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC1: view

Function for PGRMC1 Gene

Molecular function for PGRMC1 Gene

UniProtKB/Swiss-Prot Function:
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Gene Ontology (GO) - Molecular Function for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 21081644
GO:0008289 lipid binding IEA --
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC1: view
genes like me logo Genes that share phenotypes with PGRMC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC1 Gene

Localization for PGRMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC1 Gene

Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGRMC1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
nucleus 3
cytosol 2
lysosome 2
golgi apparatus 2
endosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 25390692
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 25390692
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA,IBA --
genes like me logo Genes that share ontologies with PGRMC1: view

Pathways & Interactions for PGRMC1 Gene

genes like me logo Genes that share pathways with PGRMC1: view

Pathways by source for PGRMC1 Gene

3 Reactome pathways for PGRMC1 Gene
1 Cell Signaling Technology pathway for PGRMC1 Gene

Gene Ontology (GO) - Biological Process for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PGRMC1: view

No data available for SIGNOR curated interactions for PGRMC1 Gene

Drugs & Compounds for PGRMC1 Gene

(11) Drugs for PGRMC1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator, Agonist, Inhibition, Pore Blocker Endogenous progesterone receptor agonist 600
Dextromethorphan Approved Pharma Target, binder 140
Nortriptyline Approved Pharma Antagonist, Pore Blocker, Target, binder 50
Sertraline Approved Pharma Inhibition, Inhibitor, Target, antagonist 306
OPC-14523 Investigational Pharma agonist, inhibitor 0

(2) Additional Compounds for PGRMC1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
genes like me logo Genes that share compounds with PGRMC1: view

Transcripts for PGRMC1 Gene

mRNA/cDNA for PGRMC1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(593) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGRMC1 Gene

Progesterone receptor membrane component 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PGRMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGRMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGRMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC1 Gene

This gene is overexpressed in Nasal epithelium (13.6), Bone (8.7), and Fetal testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGRMC1 Gene

Protein tissue co-expression partners for PGRMC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PGRMC1 Gene:


SOURCE GeneReport for Unigene cluster for PGRMC1 Gene:


mRNA Expression by UniProt/SwissProt for PGRMC1 Gene:

Tissue specificity: Widely expressed, with highest expression in liver and kidney.

Evidence on tissue expression from TISSUES for PGRMC1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.4)
  • Intestine(2.9)
  • Kidney(2.9)
  • Lung(2.7)
  • Eye(2.6)
  • Skin(2.6)
  • Heart(2.5)
  • Muscle(2.2)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Adrenal gland(2)
  • Bone(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PGRMC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGRMC1 Gene

Orthologs for PGRMC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGRMC1 34
  • 99 (a)
(Canis familiaris)
Mammalia PGRMC1 34 33
  • 95.38 (n)
(Bos Taurus)
Mammalia PGRMC1 34 33
  • 92.78 (n)
(Mus musculus)
Mammalia Pgrmc1 16 34 33
  • 91.79 (n)
(Ornithorhynchus anatinus)
Mammalia PGRMC1 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Pgrmc1 33
  • 87.7 (n)
(Monodelphis domestica)
Mammalia PGRMC1 34
  • 79 (a)
(Gallus gallus)
Aves PGRMC1 34 33
  • 75.39 (n)
(Anolis carolinensis)
Reptilia PGRMC1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc1 33
  • 69.41 (n)
Str.1525 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5375 33
(Danio rerio)
Actinopterygii pgrmc1 34 33
  • 65.48 (n)
Dr.26789 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.28 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000767 33
  • 62.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta MSBP 34 33
  • 54.41 (n)
CG9066 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea vem-1 34 33
  • 51.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL106W 33
  • 52.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09757g 33
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 36 34 33
  • 48.39 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07286 33
  • 54.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dap1 33
  • 50.68 (n)
Species where no ortholog for PGRMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC1 Gene

Gene Tree for PGRMC1 (if available)
Gene Tree for PGRMC1 (if available)
Evolutionary constrained regions (ECRs) for PGRMC1: view image

Paralogs for PGRMC1 Gene

Paralogs for PGRMC1 Gene

(2) SIMAP similar genes for PGRMC1 Gene using alignment to 3 proteins:

  • B7Z1L3_HUMAN
  • Q6IB11_HUMAN Pseudogenes for PGRMC1 Gene

genes like me logo Genes that share paralogs with PGRMC1: view

Variants for PGRMC1 Gene

Sequence variations from dbSNP and Humsavar for PGRMC1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000130913 -- 119,244,690(+) A/G downstream_transcript_variant
rs1001402611 -- 119,236,565(+) C/T coding_sequence_variant, missense_variant
rs1001656160 -- 119,242,011(+) T/C intron_variant
rs1001706050 -- 119,241,313(+) C/G intron_variant
rs1002008841 -- 119,234,295(+) T/A upstream_transcript_variant

Variation tolerance for PGRMC1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGRMC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGRMC1 Gene

Disorders for PGRMC1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for PGRMC1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
supraglottis cancer
  • ca larynx - supraglottis
eustachian tube disease
  • eustachian tube disorder
patulous eustachian tube
  • pet
herpetic whitlow
  • herpetic felon
trachea adenoid cystic carcinoma
  • adenoid cystic carcinoma of trachea
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PGRMC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PGRMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGRMC1 Gene

Publications for PGRMC1 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D … Falkenstein E (Biological chemistry 1998) 2 3 4 22 58
  2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PMID: 11697142) Bernauer S … Falkenstein E (DNA sequence : the journal of DNA sequencing and mapping 2001) 3 4 22 58
  3. Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1. (PMID: 28007569) Pati ML … Abate C (Pharmacological research 2017) 3 4 58
  4. Spectroscopic and mutagenesis studies of human PGRMC1. (PMID: 25675345) Kaluka D … Yeh SR (Biochemistry 2015) 3 4 58
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 44 58

Products for PGRMC1 Gene

Sources for PGRMC1 Gene

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