Aliases for PGRMC1 Gene
External Ids for PGRMC1 Gene
Previous GeneCards Identifiers for PGRMC1 Gene
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
GeneCards Summary for PGRMC1 Gene
PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Preterm Premature Rupture Of The Membranes and Placental Choriocarcinoma. Among its related pathways are Innate Immune System and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.
UniProtKB/Swiss-Prot Summary for PGRMC1 Gene
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).