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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
PGR (Progesterone Receptor) is a Protein Coding gene. Diseases associated with PGR include Progesterone Resistance and Myoma. Among its related pathways are Signaling by GPCR and Cellular roles of Anthrax toxin. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and signaling receptor binding. An important paralog of this gene is NR3C2.
Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J101126 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 621.2 | +2.7 | 2680 | 4 | PRDM10 RFX1 FOXA1 ZIC2 PKNOX1 EZH2 MGA ZFX ZBTB20 UBTF | PGR PGR-AS1 lnc-TRPC6-3 RF00994-204 ARHGAP42 | |
GH11J102108 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 10.1 | -982.7 | -982692 | 9.7 | HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 ZNF512 SOX13 NFKBIZ KDM1A | YAP1 DYNC2H1 BIRC2 CEP126 PGR ENSG00000255504 ENSG00000277459 ENSG00000260008 piR-42491-034 BIRC3 | |
GH11J101008 | Enhancer | 0.4 | Ensembl | 16.6 | +120.9 | 120880 | 3.2 | TEAD4 RFX1 SPI1 | PGR ENSG00000254506 HSALNG0086708 piR-45561-001 ARHGAP42 | |
GH11J101082 | Enhancer | 0.2 | Ensembl | 20 | +48.1 | 48080 | 0.4 | PGR RF00994-204 lnc-TRPC6-2 ARHGAP42 | ||
GH11J101091 | Enhancer | 0.5 | ENCODE | 0.3 | +38.7 | 38676 | 0.2 | FOXA1 FOS JUN JUND ESR1 GATA3 FOSL2 | RF00994-204 PGR lnc-TRPC6-2 ARHGAP42 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 17785366 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 17785366 |
GO:0003677 | DNA binding | IEA,TAS | 3551956 |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Oocyte meiosis |
.44
|
|
2 | Gene Expression |
.48
|
|
3 | Nuclear Receptor transcription pathway | ||
4 | Signaling by ERBB4 | ||
5 | Gastric cancer |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001542 | ovulation from ovarian follicle | IEA | -- |
GO:0002070 | epithelial cell maturation | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0007165 | signal transduction | TAS | 1557371 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Levonorgestrel | Approved, Investigational | Pharma | Agonist, Target, modulator, binder | Synthetic progesterone analog | 376 | |
Mifepristone | Approved, Investigational | Pharma | Agonist, Antagonist, Mixed, Target, antagonist | Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist | 182 | |
Progesterone | Approved, Vet_approved | Pharma | Activator, Full agonist, Agonist, Pore Blocker, Inhibition, Target, agonist, inhibitor | Endogenous progesterone receptor agonist | 755 | |
Dydrogesterone | Approved, Investigational, Withdrawn | Pharma | Agonist, Target, agonist | 56 | ||
Norethindrone | Approved | Pharma | Agonist, Target, agonist | 116 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Levonorgestrel | Synthetic progesterone analog | 797-63-7 |
Mifepristone | Progesterone and glucocorticoid receptor antagonist | 84371-65-3 |
Progesterone | Endogenous progesterone receptor agonist | 57-83-0 |
Compound | Action | Cas Number |
---|---|---|
Alprostadil | 745-65-3 | |
Altrenogest | 850-52-2 | |
Bazedoxifene HCl | 198480-56-7 | |
Bimatoprost | 155206-00-1 | |
Clomiphene citrate | 50-41-9 | |
Dienogest | 65928-58-7 | |
Drospirenone | 67392-87-4 | |
Dydrogesterone | 152-62-5 | |
Equol | 531-95-3 | |
Estradiol Cypionate | 313-06-4 | |
Estriol | 50-27-1 | |
Estrone | Estrogenic hormone | 53-16-7 |
Ethinyl Estradiol | Oral contraceptive | 57-63-6 |
Ethisterone | Progestogen hormone | 434-03-7 |
Ethynodiol diacetate | 297-76-7 | |
Gestodene | 60282-87-3 | |
Hexestrol | 84-16-2 | |
Levonorgestrel | 797-63-7 | |
Medroxyprogesterone | 520-85-4 | |
Medroxyprogesterone acetate | Steroidal progestin | 71-58-9 |
Megestrol Acetate | Anti-estrogen agent | 595-33-5 |
Mifepristone | Progesterone receptor antagonist | 84371-65-3 |
Ospemifene | 128607-22-7 | |
Progesterone | 57-83-0 | |
Raloxifene HCl | Estrogen receptor (ER) | 82640-04-8 |
Tamoxifen Citrate | Antiestrogen drug | 54965-24-1 |
Tanaproget | Progesterone receptor agonist | 304853-42-7 |
Toremifene Citrate | 89778-27-8 | |
Ulipristal acetate | 126784-99-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PGR 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PGR 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PGR 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PGR 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pgr 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pgr 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PGR 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PGR 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PGR 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | pgr-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pgr 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708537 | Benign: not provided | 101,128,510(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
708538 | Benign: not provided | 101,128,924(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
709071 | Benign: not provided | 101,128,712(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
710125 | Likely Benign: not provided | 101,127,748(-) | G/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
710356 | Likely Benign: not provided | 101,128,848(-) | G/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762939 | CNV | loss | 21179565 |
esv3307869 | CNV | mobile element insertion | 20981092 |
nsv1159933 | CNV | duplication | 26073780 |
nsv556130 | CNV | loss | 21841781 |
nsv556131 | CNV | gain | 21841781 |
nsv826058 | CNV | loss | 20364138 |
nsv826059 | CNV | loss | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
progesterone resistance |
|
|
myoma |
|
|
endometrial hyperplasia |
|
|
female breast cancer |
|
|
smooth muscle tumor |
|