Aliases for PGPEP1 Gene
External Ids for PGPEP1 Gene
Previous GeneCards Identifiers for PGPEP1 Gene
The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
GeneCards Summary for PGPEP1 Gene
PGPEP1 (Pyroglutamyl-Peptidase I) is a Protein Coding gene. Diseases associated with PGPEP1 include Specific Bursitis Often Of Occupational Origin and Olecranon Bursitis. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and pyroglutamyl-peptidase activity. An important paralog of this gene is PGPEP1L.
UniProtKB/Swiss-Prot Summary for PGPEP1 Gene
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.