Aliases for PGP Gene

Aliases for PGP Gene

  • Phosphoglycolate Phosphatase 2 3 4 5
  • Aspartate-Based Ubiquitous Mg(2+)-Dependent Phosphatase 3 4
  • Glycerol-3-Phosphate Phosphatase 3 4
  • G3PP 3 4
  • AUM 3 4
  • EC 3.1.3.18 54
  • EC 3.1.3.21 4
  • EC 3.1.3.48 4
  • EC 3.1.3 54
  • PGPase 3

External Ids for PGP Gene

Previous GeneCards Identifiers for PGP Gene

  • GC16U990047
  • GC16M002201
  • GC16M002261
  • GC16M002187
  • GC16M002217
  • GC16M002224
  • GC16M002228

Summaries for PGP Gene

GeneCards Summary for PGP Gene

PGP (Phosphoglycolate Phosphatase) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and protein tyrosine phosphatase activity. An important paralog of this gene is PDXP.

UniProtKB/Swiss-Prot Summary for PGP Gene

  • Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).

Additional gene information for PGP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGP Gene

Genomics for PGP Gene

GeneHancer (GH) Regulatory Elements for PGP Gene

Promoters and enhancers for PGP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGP gene promoter:
  • GATA-2
  • GR
  • GR-alpha
  • IRF-7A
  • NF-1
  • NF-1/L
  • NF-kappaB
  • p53

Genomic Locations for PGP Gene

Genomic Locations for PGP Gene
chr16:2,211,602-2,214,821
(GRCh38/hg38)
Size:
3,220 bases
Orientation:
Minus strand
chr16:2,261,603-2,264,822
(GRCh37/hg19)
Size:
3,220 bases
Orientation:
Minus strand

Genomic View for PGP Gene

Genes around PGP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGP Gene

Proteins for PGP Gene

  • Protein details for PGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDG6-PGP_HUMAN
    Recommended name:
    Glycerol-3-phosphate phosphatase
    Protein Accession:
    A6NDG6

    Protein attributes for PGP Gene

    Size:
    321 amino acids
    Molecular mass:
    34006 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

neXtProt entry for PGP Gene

Selected DME Specific Peptides for PGP Gene

A6NDG6:
  • LFDCDGVLW
  • VDTLLFDCDGVLWRGE
  • LTLTGVS
  • YVDSIADLLPAL
  • MVGDRLDTDIL

Post-translational modifications for PGP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PGP
  • Santa Cruz Biotechnology (SCBT) Antibodies for PGP

Domains & Families for PGP Gene

Gene Families for PGP Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PGP Gene

Suggested Antigen Peptide Sequences for PGP Gene

GenScript: Design optimal peptide antigens:
  • Phosphoglycolate phosphatase (PGP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NDG6

UniProtKB/Swiss-Prot:

PGP_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Family:
  • Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
genes like me logo Genes that share domains with PGP: view

Function for PGP Gene

Molecular function for PGP Gene

UniProtKB/Swiss-Prot Function:
Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycerol 1-phosphate + H2O = glycerol + phosphate; Xref=Rhea:RHEA:11476, ChEBI:CHEBI:15377, ChEBI:CHEBI:17754, ChEBI:CHEBI:43474, ChEBI:CHEBI:231935; EC=3.1.3.21; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.4 mM for glycerol-3-phosphate {ECO:0000269 PubMed:26755581}; KM=1.5 mM for 2-phosphoglycolate {ECO:0000269 PubMed:26755581}; Vmax=100 nmol/min/mg enzyme with glycerol-3-phosphate as substrate {ECO:0000269 PubMed:26755581}; Vmax=500 nmol/min/mg enzyme with 2-phosphoglycolate as substrate {ECO:0000269 PubMed:26755581}; Note=Given the respective intracellular concentrations of glycerol-3-phosphate and 2-phosphoglycolate, glycerol-3- phosphate with a concentration of 2 to 10 mM is most probably the physiological substrate. {ECO:0000269 PubMed:26755581};
GENATLAS Biochemistry:
phosphoglycolate phosphatase

Enzyme Numbers (IUBMB) for PGP Gene

Phenotypes From GWAS Catalog for PGP Gene

Gene Ontology (GO) - Molecular Function for PGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000121 glycerol-1-phosphatase activity IEA --
GO:0000287 magnesium ion binding ISS,IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity ISS --
GO:0008967 phosphoglycolate phosphatase activity IDA 26755581
genes like me logo Genes that share ontologies with PGP: view
genes like me logo Genes that share phenotypes with PGP: view

Animal Models for PGP Gene

MGI Knock Outs for PGP:
  • Pgp Pgp<tm1.2Ango>

Animal Model Products

CRISPR Products

miRNA for PGP Gene

miRTarBase miRNAs that target PGP

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PGP Gene

Localization for PGP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGP gene
Compartment Confidence
extracellular 2
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with PGP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PGP Gene

Pathways & Interactions for PGP Gene

genes like me logo Genes that share pathways with PGP: view

Pathways by source for PGP Gene

Gene Ontology (GO) - Biological Process for PGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006114 glycerol biosynthetic process IDA 26755581
GO:0006650 glycerophospholipid metabolic process IDA 26755581
GO:0016311 dephosphorylation IBA,ISS --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with PGP: view

No data available for SIGNOR curated interactions for PGP Gene

Drugs & Compounds for PGP Gene

(7) Drugs for PGP Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2231
Etoposide Approved Pharma Biomarker, inhibitor Topo II inhibitor, Topoisomerase 2 Inhibitors 1426
Paclitaxel Approved, Vet_approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 3454
Glycolic acid Approved, Investigational Pharma 24
Phosphoric acid Approved Pharma 0

(1) Additional Compounds for PGP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PGP: view

Transcripts for PGP Gene

mRNA/cDNA for PGP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGP Gene

No ASD Table

Relevant External Links for PGP Gene

GeneLoc Exon Structure for
PGP
ECgene alternative splicing isoforms for
PGP

Expression for PGP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGP Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for PGP Gene

This gene is overexpressed in Tonsil (9.7) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGP Gene



Protein tissue co-expression partners for PGP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGP Gene:

PGP

SOURCE GeneReport for Unigene cluster for PGP Gene:

Hs.442634

mRNA Expression by UniProt/SwissProt for PGP Gene:

A6NDG6-PGP_HUMAN
Tissue specificity: Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.

Evidence on tissue expression from TISSUES for PGP Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with PGP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PGP Gene

Orthologs for PGP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGP 33 32
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PGP 33 32
  • 91.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PGP 33 32
  • 90.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgp 32
  • 89.46 (n)
mouse
(Mus musculus)
Mammalia Pgp 17 33 32
  • 89.35 (n)
oppossum
(Monodelphis domestica)
Mammalia PGP 33
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGP 33
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGP 33 32
  • 73.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGP 33
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pgp 32
  • 63.51 (n)
zebrafish
(Danio rerio)
Actinopterygii pgp 33 32
  • 64.55 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011350 32
  • 51.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5567 33 32
  • 51.01 (n)
ManyToMany
CG32487 33
  • 31 (a)
ManyToMany
CG5577 33
  • 30 (a)
ManyToMany
CG11291 33
  • 27 (a)
ManyToMany
CG32488 33
  • 26 (a)
ManyToMany
CG10352 33
  • 25 (a)
ManyToMany
CG15739 33
  • 25 (a)
ManyToMany
CG2680 33
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D10.1 33 32
  • 42.87 (n)
ManyToMany
K09H11.7 33
  • 31 (a)
ManyToMany
F44E7.2 33
  • 30 (a)
ManyToMany
C53A3.2 33
  • 29 (a)
ManyToMany
C45E5.1 33
  • 28 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL184W 32
  • 53.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19382g 32
  • 44.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO13 35 33 32
  • 42.81 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGLP2 32
  • 46.3 (n)
rice
(Oryza sativa)
Liliopsida Os09g0261300 32
  • 46.81 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00088 32
  • 51.37 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pho2 32
  • 44.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9766 33
  • 42 (a)
OneToMany
Species where no ortholog for PGP was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGP Gene

ENSEMBL:
Gene Tree for PGP (if available)
TreeFam:
Gene Tree for PGP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGP: view image

Paralogs for PGP Gene

Paralogs for PGP Gene

(1) SIMAP similar genes for PGP Gene using alignment to 2 proteins:

  • PGP_HUMAN
  • H3BV17_HUMAN
genes like me logo Genes that share paralogs with PGP: view

Variants for PGP Gene

Sequence variations from dbSNP and Humsavar for PGP Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000209221 -- 2,215,300(-) C/G/T upstream_transcript_variant
rs1000468861 -- 2,215,053(-) C/G upstream_transcript_variant
rs1000631882 -- 2,213,071(-) C/T 3_prime_UTR_variant
rs1001624743 -- 2,215,302(-) T/G upstream_transcript_variant
rs1002317461 -- 2,214,490(-) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PGP Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1711 CNV insertion 18451855
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571200 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for PGP Gene

Gene Damage Index Score: 2.86; 48.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGP Gene

Disorders for PGP Gene

Additional Disease Information for PGP

No disorders were found for PGP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGP Gene

Publications for PGP Gene

  1. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes. (PMID: 26755581) Mugabo Y … Prentki M (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4 56
  2. The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia. (PMID: 17038883) Lin YC … Miller DD (Therapeutic drug monitoring 2006) 3 43 56
  3. Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness. (PMID: 16160620) de Leon J … Wedlund PJ (Journal of clinical psychopharmacology 2005) 3 43 56
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56
  5. A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling. (PMID: 29524543) Segerer G … Gohla A (Biochimica et biophysica acta. Molecular and cell biology of lipids 2018) 3 56

Products for PGP Gene

Sources for PGP Gene