Aliases for PGLYRP3 Gene
External Ids for PGLYRP3 Gene
Previous GeneCards Identifiers for PGLYRP3 Gene
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
GeneCards Summary for PGLYRP3 Gene
PGLYRP3 (Peptidoglycan Recognition Protein 3) is a Protein Coding gene. Diseases associated with PGLYRP3 include High Pressure Neurological Syndrome and Psoriasis 4. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP4.
UniProtKB/Swiss-Prot Summary for PGLYRP3 Gene
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.