This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014] See more...

Aliases for PGLYRP3 Gene

Aliases for PGLYRP3 Gene

  • Peptidoglycan Recognition Protein 3 2 3 4 5
  • PGLYRPIalpha 2 3 4
  • PGRPIA 2 3 4
  • Peptidoglycan Recognition Protein Intermediate Alpha 3 4
  • PGRP-Ialpha 2 3
  • Peptidoglycan Recognition Protein I Alpha Precursor 2
  • Peptidoglycan Recognition Protein I Alpha 3
  • Peptidoglycan Recognition Protein I-Alpha 4
  • PGRP-I-Alpha 4
  • PGLYRP3 5

External Ids for PGLYRP3 Gene

Previous GeneCards Identifiers for PGLYRP3 Gene

  • GC01M150487
  • GC01M150083
  • GC01M151536
  • GC01M153270
  • GC01M124633

Summaries for PGLYRP3 Gene

Entrez Gene Summary for PGLYRP3 Gene

  • This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

GeneCards Summary for PGLYRP3 Gene

PGLYRP3 (Peptidoglycan Recognition Protein 3) is a Protein Coding gene. Diseases associated with PGLYRP3 include High Pressure Neurological Syndrome and Psoriasis 4. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP4.

UniProtKB/Swiss-Prot Summary for PGLYRP3 Gene

  • Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Additional gene information for PGLYRP3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGLYRP3 Gene

Genomics for PGLYRP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PGLYRP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153312 Promoter 0.7 EPDnew 600.7 +0.0 6 0.1 REST CTBP1 CEBPG CTCF SKIL CEBPB IKZF1 PGLYRP3 lnc-PGLYRP4-1 piR-53227 LORICRIN
GH01J153343 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.2 -33.7 -33726 9 ZNF512 RFX1 LEF1 IKZF1 JUND DDX20 MTA2 PHF21A ZIC2 PKNOX1 PGLYRP4 lnc-S100A12-3 UBAP2L SLC27A3 PGLYRP3 RNU6-160P RF00026-073
GH01J153373 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 10.1 -62.8 -62814 1.9 CEBPG CEBPB SMARCC1 SMARCC2 JUN JUND EP300 FOSL2 GATA3 DPF2 S100A12 PGLYRP4 RNU6-160P PGLYRP3 lnc-S100A12-1 S100A7A
GH01J153306 Enhancer 0.4 Ensembl 26.3 +6.1 6074 1 SPI1 CEBPB HLF PGLYRP4 PGLYRP3 piR-53227 LORICRIN
GH01J153489 Enhancer 1 ENCODE dbSUPER 9.8 -177.9 -177852 2.1 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 PATZ1 ZNF600 ZNF37A ZNF561 SCRT2 PGLYRP4 S100A9 RNU6-160P S100A1 S100A13 CHTOP PGLYRP3 RN7SL44P S100A3 RF00017-350
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGLYRP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGLYRP3

Top Transcription factor binding sites by QIAGEN in the PGLYRP3 gene promoter:
  • c-Myc
  • COMP1
  • Ik-3
  • Lmo2
  • Max1
  • Nkx2-2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for PGLYRP3 Gene

Genomic Locations for PGLYRP3 Gene
chr1:153,297,589-153,312,975
(GRCh38/hg38)
Size:
15,387 bases
Orientation:
Minus strand
chr1:153,270,338-153,283,194
(GRCh37/hg19)
Size:
12,857 bases
Orientation:
Minus strand

Genomic View for PGLYRP3 Gene

Genes around PGLYRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP3 Gene

Proteins for PGLYRP3 Gene

  • Protein details for PGLYRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB9-PGRP3_HUMAN
    Recommended name:
    Peptidoglycan recognition protein 3
    Protein Accession:
    Q96LB9
    Secondary Accessions:
    • A1A4U8
    • Q5SY65

    Protein attributes for PGLYRP3 Gene

    Size:
    341 amino acids
    Molecular mass:
    37611 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for PGLYRP3 Gene

neXtProt entry for PGLYRP3 Gene

Post-translational modifications for PGLYRP3 Gene

Other Protein References for PGLYRP3 Gene

No data available for DME Specific Peptides for PGLYRP3 Gene

Domains & Families for PGLYRP3 Gene

Gene Families for PGLYRP3 Gene

Protein Domains for PGLYRP3 Gene

Suggested Antigen Peptide Sequences for PGLYRP3 Gene

GenScript: Design optimal peptide antigens:
  • Peptidoglycan recognition protein intermediate alpha (PGRP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LB9

UniProtKB/Swiss-Prot:

PGRP3_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP3: view

Function for PGLYRP3 Gene

Molecular function for PGLYRP3 Gene

UniProtKB/Swiss-Prot Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to Gram-positive and Gram-negative bacteria.

Phenotypes From GWAS Catalog for PGLYRP3 Gene

Gene Ontology (GO) - Molecular Function for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA --
GO:0016019 peptidoglycan receptor activity IBA,IDA 11461926
GO:0042834 peptidoglycan binding IBA,IDA 11461926
GO:0046982 protein heterodimerization activity IPI 16354652
genes like me logo Genes that share ontologies with PGLYRP3: view
genes like me logo Genes that share phenotypes with PGLYRP3: view

Animal Models for PGLYRP3 Gene

MGI Knock Outs for PGLYRP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLYRP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGLYRP3 Gene

Localization for PGLYRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLYRP3 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0016020 membrane NAS 11461926
GO:0032991 protein-containing complex IDA 16354652
genes like me logo Genes that share ontologies with PGLYRP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PGLYRP3 Gene

Pathways & Interactions for PGLYRP3 Gene

PathCards logo

SuperPathways for PGLYRP3 Gene

genes like me logo Genes that share pathways with PGLYRP3: view

Pathways by source for PGLYRP3 Gene

3 Reactome pathways for PGLYRP3 Gene

Gene Ontology (GO) - Biological Process for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009253 peptidoglycan catabolic process IEA --
GO:0016045 detection of bacterium IBA,IDA 11461926
GO:0019730 antimicrobial humoral response TAS --
GO:0031640 killing of cells of other organism IDA 16354652
genes like me logo Genes that share ontologies with PGLYRP3: view

No data available for SIGNOR curated interactions for PGLYRP3 Gene

Drugs & Compounds for PGLYRP3 Gene

(3) Drugs for PGLYRP3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE Experimental Pharma Target 0
L-Alanine Nutra Agonist, Full agonist Glycine receptor agonist 198

(2) Additional Compounds for PGLYRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
  • N-Acetyl-D-muramoate
  • N-Acetylmuramic acid
  • N-Acetyl-D-muramoic acid
  • N-Acetylisomuramic acid
  • Acetylmuramic acid
N-Acetylmuramoyl-Ala
  • N-Acetyl-D-muramoyl-L-alanine
genes like me logo Genes that share compounds with PGLYRP3: view

Transcripts for PGLYRP3 Gene

mRNA/cDNA for PGLYRP3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLYRP3

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP3 Gene

No ASD Table

Relevant External Links for PGLYRP3 Gene

GeneLoc Exon Structure for
PGLYRP3

Expression for PGLYRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGLYRP3 Gene

mRNA differential expression in normal tissues according to GTEx for PGLYRP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Skin - Sun Exposed (Lower leg) (x12.4), Skin - Not Sun Exposed (Suprapubic) (x11.5), Vagina (x8.0), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for PGLYRP3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP3 Gene



Protein tissue co-expression partners for PGLYRP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGLYRP3

SOURCE GeneReport for Unigene cluster for PGLYRP3 Gene:

Hs.348266

mRNA Expression by UniProt/SwissProt for PGLYRP3 Gene:

Q96LB9-PGRP3_HUMAN
Tissue specificity: Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.

Evidence on tissue expression from TISSUES for PGLYRP3 Gene

  • Intestine(2)
  • Skin(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PGLYRP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLYRP3 Gene

Orthologs for PGLYRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PGLYRP3 30 31
  • 99.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PGLYRP3 30 31
  • 84.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pglyrp3 30 17 31
  • 79.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pglyrp3 30
  • 79.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 61 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 50 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii pglyrp5 31
  • 28 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta PGRP-LF 30
  • 49.17 (n)
PGRP-SB1 31
  • 40 (a)
ManyToMany
PGRP-SA 31
  • 37 (a)
ManyToMany
PGRP-SD 31
  • 37 (a)
ManyToMany
PGRP-SC2 31
  • 34 (a)
ManyToMany
PGRP-SC1b 31
  • 33 (a)
ManyToMany
PGRP-SC1a 31
  • 33 (a)
ManyToMany
PGRP-SB2 31
  • 30 (a)
ManyToMany
PGRP-LB 31
  • 27 (a)
ManyToMany
Species where no ortholog for PGLYRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PGLYRP3 Gene

ENSEMBL:
Gene Tree for PGLYRP3 (if available)
TreeFam:
Gene Tree for PGLYRP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGLYRP3: view image

Paralogs for PGLYRP3 Gene

Paralogs for PGLYRP3 Gene

(2) SIMAP similar genes for PGLYRP3 Gene using alignment to 1 proteins:

  • PGRP3_HUMAN
genes like me logo Genes that share paralogs with PGLYRP3: view

Variants for PGLYRP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGLYRP3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714802 Benign: not provided 153,303,879(-) T/C SYNONYMOUS_VARIANT
719342 Benign: not provided 153,298,104(-) G/A MISSENSE_VARIANT
726936 Benign: not provided 153,310,602(-) A/G INTRON_VARIANT
727525 Benign: not provided 153,307,188(-) G/C SYNONYMOUS_VARIANT
767703 Benign: not provided 153,307,121(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PGLYRP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PGLYRP3 Gene

Variant ID Type Subtype PubMed ID
nsv999024 CNV loss 25217958

Variation tolerance for PGLYRP3 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.37; 97.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGLYRP3 Gene

Human Gene Mutation Database (HGMD)
PGLYRP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGLYRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLYRP3 Gene

Disorders for PGLYRP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PGLYRP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
high pressure neurological syndrome
psoriasis 4
  • psoriasis 4, susceptibility to
reflex epilepsy
  • epilepsy, sensory-induced
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PGLYRP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PGLYRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLYRP3 Gene

Publications for PGLYRP3 Gene

  1. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. (PMID: 16354652) Lu X … Dziarski R (The Journal of biological chemistry 2006) 3 4 23
  2. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. (PMID: 16641493) Guan R … Mariuzza RA (Protein science : a publication of the Protein Society 2006) 3 4 23
  3. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C … Dziarski R (The Journal of biological chemistry 2001) 2 3 4
  4. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S … Hoffjan S (International journal of immunogenetics 2009) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PGLYRP3 Gene

  • Signalway ELISA kits for PGLYRP3
  • Signalway Proteins for PGLYRP3

Sources for PGLYRP3 Gene