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Aliases for PGLYRP2 Gene

Aliases for PGLYRP2 Gene

  • Peptidoglycan Recognition Protein 2 2 3 4 5
  • Peptidoglycan Recognition Protein Long 3 4
  • N-Acetylmuramoyl-L-Alanine Amidase 2 3
  • PGLYRPL 3 4
  • PGRP-L 3 4
  • PGRPL 3 4
  • Peptidoglycan Recognition Protein L Precursor 2
  • Peptidoglycan Recognition Protein-Like 2
  • Peptidoglycan Recognition Protein L 3
  • EC 3.5.1.28 4
  • TagL-Alpha 3
  • TAGL-Like 3
  • Tagl-Beta 3
  • HMFT0141 3
  • TagL 3

External Ids for PGLYRP2 Gene

Previous GeneCards Identifiers for PGLYRP2 Gene

  • GC19M015442
  • GC19M015443
  • GC19M015579
  • GC19M015147

Summaries for PGLYRP2 Gene

Entrez Gene Summary for PGLYRP2 Gene

  • This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

GeneCards Summary for PGLYRP2 Gene

PGLYRP2 (Peptidoglycan Recognition Protein 2) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP4.

UniProtKB/Swiss-Prot for PGLYRP2 Gene

  • May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Gene Wiki entry for PGLYRP2 Gene

Additional gene information for PGLYRP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLYRP2 Gene

Genomics for PGLYRP2 Gene

GeneHancer (GH) Regulatory Elements for PGLYRP2 Gene

Promoters and enhancers for PGLYRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015479 Promoter 1 EPDnew 650.4 +19.4 19435 0.1 NCOA3 CTCF ESRRA TAF1 SAP130 ARID4B MAX SIN3A THRB ZNF48 PGLYRP2 GC19M015481 RASAL3 GC19M015202
GH19J015499 Enhancer 0.9 FANTOM5 ENCODE 654.2 -0.3 -282 0.3 PKNOX1 SP3 SP2 REST ZIC2 SP1 ZFHX2 GLIS1 CREB1 PRDM10 PGLYRP2 CYP4F22 CYP4F2 CYP4F3 CYP4F11 OR10H4 OR1I1 GC19M015202
GH19J015550 Enhancer 1 Ensembl ENCODE 12.2 -52.5 -52452 1.2 KLF14 ZNF335 GLIS2 EGR1 KLF13 EGR2 SP3 USF2 SP1 NFIC CYP4F22 PGLYRP2 RASAL3 AKAP8L CYP4F11 GC19P015545 CYP4F23P
GH19J015456 Enhancer 0.6 ENCODE 12.3 +42.0 41991 0.2 PKNOX1 KLF1 SP2 SIN3A KLF14 KLF9 KLF8 EZH2 PGLYRP2 AKAP8L RASAL3 WIZ GC19M015202
GH19J015480 Enhancer 0.8 ENCODE 0.4 +19.1 19121 0.1 CTCF ESRRA TAF1 SAP130 NFIB ARID4B MAX SIN3A THRB ZNF48 GC19M015481 PGLYRP2 RASAL3 GC19M015202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGLYRP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGLYRP2 gene promoter:
  • AP-1
  • Sp1
  • ATF-2
  • c-Jun

Genomic Locations for PGLYRP2 Gene

Genomic Locations for PGLYRP2 Gene
chr19:15,468,645-15,498,956
(GRCh38/hg38)
Size:
30,312 bases
Orientation:
Minus strand
chr19:15,579,456-15,609,767
(GRCh37/hg19)
Size:
30,312 bases
Orientation:
Minus strand

Genomic View for PGLYRP2 Gene

Genes around PGLYRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP2 Gene

Proteins for PGLYRP2 Gene

  • Protein details for PGLYRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD5-PGRP2_HUMAN
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase
    Protein Accession:
    Q96PD5
    Secondary Accessions:
    • A8K050
    • A8K8C7
    • B2RMZ2
    • B7ZM33
    • Q68CK1
    • Q96N74
    • Q9UC60

    Protein attributes for PGLYRP2 Gene

    Size:
    576 amino acids
    Molecular mass:
    62217 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGLYRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGLYRP2 Gene

Post-translational modifications for PGLYRP2 Gene

  • Glycosylation at isoforms=2485, isoforms=2367, and isoforms=277
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PGRP2_HUMAN (784)

Other Protein References for PGLYRP2 Gene

No data available for DME Specific Peptides for PGLYRP2 Gene

Domains & Families for PGLYRP2 Gene

Gene Families for PGLYRP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PGLYRP2 Gene

Suggested Antigen Peptide Sequences for PGLYRP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PD5

UniProtKB/Swiss-Prot:

PGRP2_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP2: view

Function for PGLYRP2 Gene

Molecular function for PGLYRP2 Gene

UniProtKB/Swiss-Prot Function:
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Enzyme Numbers (IUBMB) for PGLYRP2 Gene

Gene Ontology (GO) - Molecular Function for PGLYRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity EXP,TAS 7663175
GO:0016019 peptidoglycan receptor activity IDA 11461926
GO:0016787 hydrolase activity IEA --
GO:0042834 peptidoglycan binding IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP2: view
genes like me logo Genes that share phenotypes with PGLYRP2: view

Animal Models for PGLYRP2 Gene

MGI Knock Outs for PGLYRP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PGLYRP2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGLYRP2 Gene

Localization for PGLYRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP2 Gene

Secreted. Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLYRP2 gene
Compartment Confidence
extracellular 5
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGLYRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular NAS 11461926
GO:0016020 membrane NAS 11461926
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PGLYRP2: view

Pathways & Interactions for PGLYRP2 Gene

genes like me logo Genes that share pathways with PGLYRP2: view

Pathways by source for PGLYRP2 Gene

3 Reactome pathways for PGLYRP2 Gene

Interacting Proteins for PGLYRP2 Gene

Gene Ontology (GO) - Biological Process for PGLYRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001519 peptide amidation NAS 7663175
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002376 immune system process IEA --
GO:0009253 peptidoglycan catabolic process IEA --
GO:0016045 detection of bacterium IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP2: view

No data available for SIGNOR curated interactions for PGLYRP2 Gene

Drugs & Compounds for PGLYRP2 Gene

(5) Drugs for PGLYRP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Zinc Approved, Investigational Pharma Target 2430
Water Approved Pharma 0
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0

(4) Additional Compounds for PGLYRP2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
  • N-Acetyl-D-muramoate
  • N-Acetylmuramic acid
  • N-Acetyl-D-muramoic acid
  • N-Acetylisomuramic acid
  • Acetylmuramic acid
N-Acetylmuramoyl-Ala
  • N-Acetyl-D-muramoyl-L-alanine
genes like me logo Genes that share compounds with PGLYRP2: view

Transcripts for PGLYRP2 Gene

mRNA/cDNA for PGLYRP2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGLYRP2 Gene

Peptidoglycan recognition protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP2 Gene

No ASD Table

Relevant External Links for PGLYRP2 Gene

GeneLoc Exon Structure for
PGLYRP2
ECgene alternative splicing isoforms for
PGLYRP2

Expression for PGLYRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGLYRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGLYRP2 Gene

This gene is overexpressed in Liver (x48.1).

Protein differential expression in normal tissues from HIPED for PGLYRP2 Gene

This gene is overexpressed in Serum (31.5), Plasma (13.9), and Synovial fluid (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP2 Gene



Protein tissue co-expression partners for PGLYRP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGLYRP2 Gene:

PGLYRP2

SOURCE GeneReport for Unigene cluster for PGLYRP2 Gene:

Hs.282244

mRNA Expression by UniProt/SwissProt for PGLYRP2 Gene:

Q96PD5-PGRP2_HUMAN
Tissue specificity: Strongly expressed in liver and fetal liver, and secreted into serum. Expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach and testis. Isoform 2 is not detected in the liver or serum.

Evidence on tissue expression from TISSUES for PGLYRP2 Gene

  • Liver(4.5)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with PGLYRP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLYRP2 Gene

Orthologs for PGLYRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGLYRP2 34 33
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PGLYRP2 34 33
  • 81.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PGLYRP2 34 33
  • 79.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pglyrp2 16 34 33
  • 78.11 (n)
rat
(Rattus norvegicus)
Mammalia Pglyrp2 33
  • 76.14 (n)
oppossum
(Monodelphis domestica)
Mammalia PGLYRP2 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGLYRP2 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGLYRP2 34 33
  • 58.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGLYRP2 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pglyrp2 33
  • 48.35 (n)
zebrafish
(Danio rerio)
Actinopterygii pglyrp6 34 33
  • 52.97 (n)
OneToMany
pglyrp2 34
  • 37 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.535 33
African malaria mosquito
(Anopheles gambiae)
Insecta PGRPLB 33
  • 53.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta PGRP-LB 33
  • 51.34 (n)
PGRP-LE 34
  • 25 (a)
OneToMany
PGRP-LA 34
  • 19 (a)
OneToMany
PGRP-LF 34
  • 15 (a)
OneToMany
Species where no ortholog for PGLYRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGLYRP2 Gene

ENSEMBL:
Gene Tree for PGLYRP2 (if available)
TreeFam:
Gene Tree for PGLYRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGLYRP2: view image

Paralogs for PGLYRP2 Gene

Paralogs for PGLYRP2 Gene

(1) SIMAP similar genes for PGLYRP2 Gene using alignment to 4 proteins:

  • PGRP2_HUMAN
  • B7ZM33_HUMAN
  • M0QYW3_HUMAN
  • M0R2W8_HUMAN
genes like me logo Genes that share paralogs with PGLYRP2: view

Variants for PGLYRP2 Gene

Sequence variations from dbSNP and Humsavar for PGLYRP2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000072285 -- 15,480,558(-) G/A upstream_transcript_variant
rs1000114048 -- 15,470,890(-) C/T intron_variant
rs1000226092 -- 15,476,851(-) C/T intron_variant
rs1000615247 -- 15,472,044(-) G/A coding_sequence_variant, missense_variant
rs1001066133 -- 15,469,623(-) A/G coding_sequence_variant, intron_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PGLYRP2 Gene

Variant ID Type Subtype PubMed ID
nsv1064684 CNV gain 25217958
nsv828466 CNV gain 20364138
nsv833765 CNV loss 17160897

Variation tolerance for PGLYRP2 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGLYRP2 Gene

Human Gene Mutation Database (HGMD)
PGLYRP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGLYRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLYRP2 Gene

Disorders for PGLYRP2 Gene

Additional Disease Information for PGLYRP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PGLYRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGLYRP2 Gene

Publications for PGLYRP2 Gene

  1. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. (PMID: 14506276) Wang ZM … Dziarski R (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C … Dziarski R (The Journal of biological chemistry 2001) 2 3 4 22 58
  3. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. (PMID: 16054449) Zhang Y … Dziarski R (Biochimica et biophysica acta 2005) 3 4 22 58
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58

Products for PGLYRP2 Gene

Sources for PGLYRP2 Gene

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