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This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provide... See more...
Aliases for PGLYRP2 Gene
Aliases for PGLYRP2 Gene
External Ids for PGLYRP2 Gene
- HGNC: 30013
- Entrez Gene: 114770
- Ensembl: ENSG00000161031
- OMIM: 608199
- UniProtKB: Q96PD5
Previous GeneCards Identifiers for PGLYRP2 Gene
- GC19M015442
- GC19M015443
- GC19M015579
- GC19M015147
Summaries for PGLYRP2 Gene
-
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
GeneCards Summary for PGLYRP2 Gene
PGLYRP2 (Peptidoglycan Recognition Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP3.
UniProtKB/Swiss-Prot Summary for PGLYRP2 Gene
-
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
Additional gene information for PGLYRP2 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGLYRP2 Gene
Genomics for PGLYRP2 Gene
GeneHancer (GH) Regulatory Elements for PGLYRP2 Gene
Promoters and enhancers for PGLYRP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PGLYRP2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGLYRP2
- Top Transcription factor binding sites by QIAGEN in the PGLYRP2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- Sp1
Genomic Locations for PGLYRP2 Gene
Genomic Locations for PGLYRP2 Gene
- chr19:15,468,645-15,498,956
- (GRCh38/hg38)
- Size:
- 30,312 bases
- Orientation:
- Minus strand
- chr19:15,579,456-15,609,767
- (GRCh37/hg19)
- Size:
- 30,312 bases
- Orientation:
- Minus strand
Genomic View for PGLYRP2 Gene
Genes around PGLYRP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by HGNC
- 19p13.12 by Entrez Gene
- 19p13.12 by Ensembl
PGLYRP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PGLYRP2 Gene
Proteins for PGLYRP2 Gene
-
Protein details for PGLYRP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PD5-PGRP2_HUMAN
- Recommended name:
- N-acetylmuramoyl-L-alanine amidase
- Protein Accession:
- Q96PD5
- A8K050
- A8K8C7
- B2RMZ2
- B7ZM33
- Q68CK1
- Q96N74
- Q9UC60
Protein attributes for PGLYRP2 Gene
- Size:
- 576 amino acids
- Molecular mass:
- 62217 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- [Isoform 1]: Major isoform.
- [Isoform 2]: May be due to an intron retention.
Protein Expression for PGLYRP2 Gene
Post-translational modifications for PGLYRP2 Gene
Other Protein References for PGLYRP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-PGLYRP2 monoclonal antibody, clone 56H2
- Creative Biolabs Recombinant Anti-Human PGLYRP2 Antibody and Mouse Anti-PGLYRP2 Recombinant Antibody (45G1)
- Novus Biologicals Antibodies for PGLYRP2
- Invitrogen Antibodies for PGLYRP2 (AFLGC-PGLYRP2)
-
Biorbyt antibodies for PGLYRP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PGLYRP2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PGLYRP2
- Origene Custom Protein Services for PGLYRP2
Assay Products
- Aviva Systems Biology PGLYRP2 ELISA Kit (Human) (OKEH02439) and PGLYRP2 ELISA Kit (Human) (OKCD08563)
No data available for DME Specific Peptides for PGLYRP2 Gene
Domains & Families for PGLYRP2 Gene
Gene Families for PGLYRP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PGLYRP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PGLYRP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Peptidoglycan recognition protein 2 (B7ZM33_HUMAN)
- Peptidoglycan recognition protein long (PGRP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96PD5- Family:
-
- Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Function for PGLYRP2 Gene
Molecular function for PGLYRP2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.; EC=3.5.1.28;.
Enzyme Numbers (IUBMB) for PGLYRP2 Gene
Phenotypes From GWAS Catalog for PGLYRP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity | TAS | 7663175 |
| GO:0016019 | peptidoglycan receptor activity | IDA,IBA | 11461926 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0042834 | peptidoglycan binding | IDA,IBA | 11461926 |
Phenotypes for PGLYRP2 Gene
- MGI mutant phenotypes for PGLYRP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PGLYRP2:
Animal Models for PGLYRP2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PGLYRP2
CRISPR Products
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PGLYRP2
miRNA Products
Inhibitory RNA Products
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- Overview of 69 available PGLYRP2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PGLYRP2 - Select products 50% OFF >
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Cell Line Products
-
Horizon Cell Lines for PGLYRP2
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGLYRP2 Gene
Localization for PGLYRP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP2 Gene
- Secreted. Membrane.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| lysosome | 0 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0016020 | membrane | NAS | 11461926 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for PGLYRP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Defensins | ||
Pathways by source for PGLYRP2 Gene
3 Reactome pathways for PGLYRP2 Gene
Interacting Proteins for PGLYRP2 Gene
GPS-Prot Interaction Network for PGLYRP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001519 | peptide amidation | NAS | 7663175 |
| GO:0002221 | pattern recognition receptor signaling pathway | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0009253 | peptidoglycan catabolic process | IEA | -- |
| GO:0016045 | detection of bacterium | IDA,IBA | 11461926 |
No data available for SIGNOR curated interactions for PGLYRP2 Gene
Drugs & Compounds for PGLYRP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 236 | ||
| Zinc | Approved, Investigational | Pharma | Target | 2822 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target | 0 | ||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| N-Acetylmuramate |
|
|
||||
| N-Acetylmuramoyl-Ala |
|
|
Transcripts for PGLYRP2 Gene
mRNA/cDNA for PGLYRP2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000292609 2758 bps (ENST00000292609.8)
- ENST00000340880 1879 bps (ENST00000340880.5)
- ENST00000594637 651 bps (ENST00000594637.1)
- ENST00000601792 578 bps (ENST00000601792.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PGLYRP2 - Select products 50% OFF >
- * PGLYRP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PGLYRP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PGLYRP2
- genomics-online: gRNA clones - Search for available PGLYRP2 gRNA products
- Overview of 69 available PGLYRP2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PGLYRP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PGLYRP2
- Browse OriGene Inhibitory RNA Products For PGLYRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLYRP2
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Clone Products
- Applied Biological Materials (abm): Clones for PGLYRP2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for PGLYRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PGLYRP2
Relevant External Links for PGLYRP2 Gene
- GeneLoc Exon Structure for
- PGLYRP2
Expression for PGLYRP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for PGLYRP2 Gene
This gene is overexpressed in Liver (x48.1).
This gene is overexpressed in Serum (31.5), Plasma (13.9), and Synovial fluid (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGLYRP2
SOURCE GeneReport for Unigene cluster for PGLYRP2 Gene:
Hs.282244mRNA Expression by UniProt/SwissProt for PGLYRP2 Gene:
Q96PD5-PGRP2_HUMAN
Tissue specificity:
Strongly expressed in liver and fetal liver, and secreted into serum. Expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach and testis. Isoform 2 is not detected in the liver or serum.
Evidence on tissue expression from TISSUES for PGLYRP2 Gene
- Liver(4.5)
- Bone marrow(4.1)
Primer Products
-
OriGene qPCR primer pairs for PGLYRP2
-
OriGene qPCR primer pairs and template standards for PGLYRP2
- genomics-online: primer clones - Search for available PGLYRP2 Primer products
- Overview of 69 available PGLYRP2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLYRP2 Gene
Orthologs for PGLYRP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PGLYRP2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PGLYRP2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PGLYRP2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pglyrp2 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pglyrp2 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PGLYRP2 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PGLYRP2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PGLYRP2 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PGLYRP2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pglyrp2 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pglyrp6 31 30 |
|
OneToMany | |
| pglyrp2 31 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.535 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | PGRPLB 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | PGRP-LB 30 |
|
||
| PGRP-LE 31 |
|
OneToMany | |||
| PGRP-LA 31 |
|
OneToMany | |||
| PGRP-LF 31 |
|
OneToMany |
- Species where no ortholog for PGLYRP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PGLYRP2 Gene
- ENSEMBL:
- Gene Tree for PGLYRP2 (if available)
- TreeFam:
- Gene Tree for PGLYRP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PGLYRP2: view image
Paralogs for PGLYRP2 Gene
Variants for PGLYRP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGLYRP2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 720778 | Benign: not provided | 15,475,969(-) | C/A | MISSENSE_VARIANT | |
| rs2304200 | - | p.Arg476Trp | |||
| rs28404490 | - | p.Thr257Asn | |||
| rs34440547 | - | p.Arg394Gln | |||
| rs3813135 | - | p.Thr46Ala |
Residual Variation Intolerance Score:
74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.12;
80.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PGLYRP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLYRP2 Gene
Disorders for PGLYRP2 Gene
Additional Disease Information for PGLYRP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PGLYRP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGLYRP2 Gene
Publications for PGLYRP2 Gene
- Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. (PMID: 14506276) Wang ZM … Dziarski R (The Journal of biological chemistry 2003) 2 3 4 23 54
- Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C … Dziarski R (The Journal of biological chemistry 2001) 2 3 4 23 54
- Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. (PMID: 16054449) Zhang Y … Dziarski R (Biochimica et biophysica acta 2005) 3 4 23 54
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
- Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D … Taylor PR (International journal of cancer 2008) 3 41 54
ExternalLinks
Products for PGLYRP2 Gene
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- Humanized Mice
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- antibodies-online: Show 7 available PGLYRP2 Antibodies ranked by validation data
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- Biorbyt antibodies for PGLYRP2
Sources for PGLYRP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
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