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This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
PGLYRP2 (Peptidoglycan Recognition Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity | IDA,TAS | 7663175 |
GO:0016019 | peptidoglycan receptor activity | IBA,IDA | 11461926 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0016020 | membrane | NAS | 11461926 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Defensins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001519 | peptide amidation | NAS | 7663175 |
GO:0002376 | immune system process | IEA | -- |
GO:0009253 | peptidoglycan catabolic process | IEA | -- |
GO:0016045 | detection of bacterium | IBA,IDA | 11461926 |
GO:0019730 | antimicrobial humoral response | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 271 | ||
Zinc | Approved, Investigational | Pharma | Target | 1687 | ||
zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
Zinc chloride | Approved, Investigational | Pharma | Target, binder | 0 | ||
Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, binder | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
N-Acetylmuramate |
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|
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N-Acetylmuramoyl-Ala |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PGLYRP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PGLYRP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PGLYRP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pglyrp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pglyrp2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PGLYRP2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PGLYRP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PGLYRP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PGLYRP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pglyrp2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pglyrp6 30 31 |
|
OneToMany | |
pglyrp2 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.535 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | PGRPLB 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | PGRP-LB 30 |
|
||
PGRP-LE 31 |
|
OneToMany | |||
PGRP-LA 31 |
|
OneToMany | |||
PGRP-LF 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs144572782 | Benign: not provided | 15,475,969(-) |
C/A NM_052890.4(PGLYRP2):c.701G>T (p.Gly234Val) |
MISSENSE | |
rs2304200 | - |
p.Arg476Trp |
|||
rs28404490 | - |
p.Thr257Asn |
|||
rs34440547 | - |
p.Arg394Gln |
|||
rs3813135 | - |
p.Thr46Ala |
No disorders were found for PGLYRP2 Gene.