Aliases for PGLYRP1 Gene

Aliases for PGLYRP1 Gene

  • Peptidoglycan Recognition Protein 1 2 3 4 5
  • PGRP-S 2 3 4
  • PGRP 2 3 4
  • TNFSF3L 3 4
  • PGLYRP 3 4
  • PGRPS 2 3
  • TAG7 2 3
  • TNF Superfamily, Member 3 (LTB)-Like (Peptidoglycan Recognition Protein) 3
  • Peptidoglycan Recognition Protein Short 4
  • Peptidoglycan Recognition Protein 2
  • PGLYRP1 5

External Ids for PGLYRP1 Gene

Previous HGNC Symbols for PGLYRP1 Gene

  • TNFSF3L
  • PGLYRP

Previous GeneCards Identifiers for PGLYRP1 Gene

  • GC19M051215
  • GC19M051216
  • GC19M046522
  • GC19M042950

Summaries for PGLYRP1 Gene

GeneCards Summary for PGLYRP1 Gene

PGLYRP1 (Peptidoglycan Recognition Protein 1) is a Protein Coding gene. Diseases associated with PGLYRP1 include Spherocytosis, Type 2 and Mite Infestation. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP3.

UniProtKB/Swiss-Prot Summary for PGLYRP1 Gene

  • Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Gene Wiki entry for PGLYRP1 Gene

Additional gene information for PGLYRP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGLYRP1 Gene

Genomics for PGLYRP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PGLYRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046024 Promoter 0.8 EPDnew Ensembl 600.7 -0.1 -51 0.6 SPI1 ZMYM3 LOC105372421 PGLYRP1 PTGIR IGFL4
GH19J046021 Enhancer 0.6 ENCODE 600.7 +1.4 1415 0.1 ZIC2 REST KLF9 ZFHX2 BCOR CTCF PRDM4 GLIS1 ZNF184 KLF16 LOC105372421 PGLYRP1 CCDC61 CLASRP ENSG00000268810 MIR769
GH19J046025 Promoter 0.5 Ensembl 600.7 +0.6 552 0.2 USF1 ZKSCAN1 LOC105372421 PGLYRP1 MIR769 CCDC61
GH19J046263 Enhancer 1.1 Ensembl ENCODE 11.1 -240.0 -240048 1.8 SP1 PRDM10 ZNF629 ZNF692 POLR2A ZNF174 ZNF300 PATZ1 IKZF2 ZNF311 IRF2BP1 ZC3H4 CCDC61 PPP5D1 ENSG00000269124 NOVA2 ENSG00000268810 PNMA8A HIF3A IGFL4
GH19J045952 Enhancer 0.9 ENCODE 11.3 +68.3 68281 4.5 ZBTB33 ZNF629 REST TFE3 RFX1 NFKBIZ RFX5 ZNF692 GABPA ZNF143 CCDC61 MYPOP MIR769 PGLYRP1 FOXA3 SYMPK IGFL4 HIF3A DMWD ERCC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGLYRP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGLYRP1

Top Transcription factor binding sites by QIAGEN in the PGLYRP1 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXD3
  • GR
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • MZF-1
  • Pax-5

Genomic Locations for PGLYRP1 Gene

Genomic Locations for PGLYRP1 Gene
chr19:46,019,153-46,023,053
(GRCh38/hg38)
Size:
3,901 bases
Orientation:
Minus strand
chr19:46,522,411-46,526,556
(GRCh37/hg19)
Size:
4,146 bases
Orientation:
Minus strand

Genomic View for PGLYRP1 Gene

Genes around PGLYRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP1 Gene

Proteins for PGLYRP1 Gene

  • Protein details for PGLYRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75594-PGRP1_HUMAN
    Recommended name:
    Peptidoglycan recognition protein 1
    Protein Accession:
    O75594
    Secondary Accessions:
    • Q4VB36

    Protein attributes for PGLYRP1 Gene

    Size:
    196 amino acids
    Molecular mass:
    21731 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for PGLYRP1 Gene

neXtProt entry for PGLYRP1 Gene

Post-translational modifications for PGLYRP1 Gene

  • N-glycosylated. N-glycosylation is required for bactericidal activity.
  • Glycosylation at Asn112
  • Modification sites at PhosphoSitePlus

Other Protein References for PGLYRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for PGLYRP1
  • Abcam proteins for PGLYRP1

No data available for DME Specific Peptides for PGLYRP1 Gene

Domains & Families for PGLYRP1 Gene

Gene Families for PGLYRP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for PGLYRP1 Gene

InterPro:
Blocks:
  • N-acetylmuramoyl-L-alanine amidase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for PGLYRP1 Gene

GenScript: Design optimal peptide antigens:
  • Peptidoglycan recognition protein short (PGRP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75594

UniProtKB/Swiss-Prot:

PGRP1_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP1: view

Function for PGLYRP1 Gene

Molecular function for PGLYRP1 Gene

UniProtKB/Swiss-Prot Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Phenotypes From GWAS Catalog for PGLYRP1 Gene

Gene Ontology (GO) - Molecular Function for PGLYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA --
GO:0016019 peptidoglycan receptor activity IBA,IDA 11461926
GO:0042834 peptidoglycan binding IBA,IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP1: view
genes like me logo Genes that share phenotypes with PGLYRP1: view

Animal Models for PGLYRP1 Gene

MGI Knock Outs for PGLYRP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PGLYRP1

CRISPR Products

miRNA for PGLYRP1 Gene

miRTarBase miRNAs that target PGLYRP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLYRP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PGLYRP1 Gene

Localization for PGLYRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP1 Gene

Secreted. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLYRP1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PGLYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:0070062 extracellular exosome HDA 19056867
GO:0097013 phagocytic vesicle lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PGLYRP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PGLYRP1 Gene

Pathways & Interactions for PGLYRP1 Gene

PathCards logo

SuperPathways for PGLYRP1 Gene

genes like me logo Genes that share pathways with PGLYRP1: view

Pathways by source for PGLYRP1 Gene

Gene Ontology (GO) - Biological Process for PGLYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009253 peptidoglycan catabolic process IEA --
GO:0009617 response to bacterium IEA --
GO:0016045 detection of bacterium IBA,IDA 11461926
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with PGLYRP1: view

No data available for SIGNOR curated interactions for PGLYRP1 Gene

Drugs & Compounds for PGLYRP1 Gene

(6) Drugs for PGLYRP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
L-Alanine Nutra Agonist, Full agonist Glycine receptor agonist 198

(6) Additional Compounds for PGLYRP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
  • N-Acetyl-D-muramoate
  • N-Acetylmuramic acid
  • N-Acetyl-D-muramoic acid
  • N-Acetylisomuramic acid
  • Acetylmuramic acid
N-Acetylmuramoyl-Ala
  • N-Acetyl-D-muramoyl-L-alanine
genes like me logo Genes that share compounds with PGLYRP1: view

Transcripts for PGLYRP1 Gene

mRNA/cDNA for PGLYRP1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLYRP1

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP1 Gene

No ASD Table

Relevant External Links for PGLYRP1 Gene

GeneLoc Exon Structure for
PGLYRP1

Expression for PGLYRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGLYRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGLYRP1 Gene

This gene is overexpressed in Whole Blood (x49.2).

Protein differential expression in normal tissues from HIPED for PGLYRP1 Gene

This gene is overexpressed in Urine (28.4), Lavage (22.4), and Neutrophil (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP1 Gene



Protein tissue co-expression partners for PGLYRP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGLYRP1

SOURCE GeneReport for Unigene cluster for PGLYRP1 Gene:

Hs.137583

mRNA Expression by UniProt/SwissProt for PGLYRP1 Gene:

O75594-PGRP1_HUMAN
Tissue specificity: Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.

Evidence on tissue expression from TISSUES for PGLYRP1 Gene

  • Bone marrow(4.6)
  • Blood(2.8)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with PGLYRP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLYRP1 Gene

Orthologs for PGLYRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PGLYRP1 30 31
  • 97.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PGLYRP1 30 31
  • 78.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PGLYRP1 30 31
  • 77.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pglyrp1 30 17 31
  • 75.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pglyrp1 30
  • 73.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia PGLYRP1 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PGLYRP1 31
  • 32 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii pglyrp5 30 31
  • 47.93 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta PGRP-SC1b 31
  • 42 (a)
ManyToMany
PGRP-SC1a 31
  • 42 (a)
ManyToMany
PGRP-SC2 31
  • 40 (a)
ManyToMany
PGRP-SA 31
  • 34 (a)
ManyToMany
PGRP-SD 31
  • 34 (a)
ManyToMany
PGRP-SB1 31
  • 33 (a)
ManyToMany
PGRP-SB2 31
  • 27 (a)
ManyToMany
PGRP-LB 31
  • 23 (a)
ManyToMany
Species where no ortholog for PGLYRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PGLYRP1 Gene

ENSEMBL:
Gene Tree for PGLYRP1 (if available)
TreeFam:
Gene Tree for PGLYRP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGLYRP1: view image

Paralogs for PGLYRP1 Gene

Paralogs for PGLYRP1 Gene

(3) SIMAP similar genes for PGLYRP1 Gene using alignment to 1 proteins:

  • PGRP1_HUMAN
genes like me logo Genes that share paralogs with PGLYRP1: view

Variants for PGLYRP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGLYRP1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34180629 - p.Val34Gly

Additional dbSNP identifiers (rs#s) for PGLYRP1 Gene

Variation tolerance for PGLYRP1 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGLYRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGLYRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGLYRP1 Gene

Disorders for PGLYRP1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for PGLYRP1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
spherocytosis, type 2
  • sph2
mite infestation
  • mite infestations
psoriasis 4
  • psoriasis 4, susceptibility to
spherocytosis, type 1
  • sph1
psoriasis 5
  • psoriasis 5, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PGLYRP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PGLYRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLYRP1 Gene

Publications for PGLYRP1 Gene

  1. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. (PMID: 9707603) Kang D … Steiner H (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23
  2. Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. (PMID: 15769462) Guan R … Mariuzza RA (Journal of molecular biology 2005) 3 4 23
  3. [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]. (PMID: 12669421) Kibardin AV … Kiselev SL (Genetika 2003) 2 3 23
  4. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C … Dziarski R (The Journal of biological chemistry 2001) 3 4 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for PGLYRP1 Gene

  • Boster Bio Antibodies for PGLYRP1
  • Boster Bio ELISA Kits for PGLYRP1
  • Signalway ELISA kits for PGLYRP1
  • Signalway Proteins for PGLYRP1

Sources for PGLYRP1 Gene