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Aliases for PGLS Gene

Aliases for PGLS Gene

  • 6-Phosphogluconolactonase 2 3 3 5
  • EC 4 56
  • 6PGL 3 4
  • Epididymis Secretory Protein Li 304 3
  • HEL-S-304 3

External Ids for PGLS Gene

Previous GeneCards Identifiers for PGLS Gene

  • GC19P018116
  • GC19P018014
  • GC19P017467
  • GC19P017484
  • GC19P017485
  • GC19P017486
  • GC19P017622
  • GC19P017189
  • GC19P017556
  • GC19P017702
  • GC19P017726
  • GC19P018301
  • GC19P018693
  • GC19P019003
  • GC19P019323

Summaries for PGLS Gene

GeneCards Summary for PGLS Gene

PGLS (6-Phosphogluconolactonase) is a Protein Coding gene. Diseases associated with PGLS include Lymph Node Disease and Lymphatic System Disease. Among its related pathways are Glycosaminoglycan metabolism and Pentose phosphate pathway. Gene Ontology (GO) annotations related to this gene include monosaccharide binding and 6-phosphogluconolactonase activity.

UniProtKB/Swiss-Prot for PGLS Gene

  • Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Additional gene information for PGLS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLS Gene

Genomics for PGLS Gene

GeneHancer (GH) Regulatory Elements for PGLS Gene

Promoters and enhancers for PGLS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017507 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 559.7 -1.5 -1479 5.9 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 PGLS PIR43275 LOC100507551 IQCN MED26 ENSG00000269578 CHERP HAUS8 ENSG00000269427 SIN3B
GH19I018372 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 +869.5 869477 18 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 GDF15 NR2C2AP ENSG00000268030 UPF1 ENSG00000268938 MEF2B COLGALT1 SUGP2 MVB12A IQCN
GH19I017552 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 14.1 +43.2 43235 4.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 COLGALT1 ENSG00000269578 ENSG00000267904 ENSG00000268087 MVB12A ENSG00000268938 ENSG00000268743 GTPBP3 IQCN ENSG00000269191
GH19I018277 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.9 +769.0 769005 6.4 MLX FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC JUND GC19P020223 PIR55689 MIR3188 IQCN UPF1 ENSG00000268030 ENSG00000268938 NR2C2AP ENSG00000269191
GH19I017225 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 -284.8 -284810 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF766 OCEL1 MVB12A PGLS ENSG00000269578 ENSG00000268087 COLGALT1 USE1 ANKLE1 GC19M017243
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PGLS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGLS gene promoter:

Genomic Locations for PGLS Gene

Genomic Locations for PGLS Gene
9,666 bases
Plus strand

Genomic View for PGLS Gene

Genes around PGLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLS Gene

Proteins for PGLS Gene

  • Protein details for PGLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for PGLS Gene

    258 amino acids
    Molecular mass:
    27547 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72960.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PGLS Gene

Selected DME Specific Peptides for PGLS Gene


Post-translational modifications for PGLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGLS Gene

Domains & Families for PGLS Gene

Gene Families for PGLS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PGLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
genes like me logo Genes that share domains with PGLS: view

Function for PGLS Gene

Molecular function for PGLS Gene

GENATLAS Biochemistry:
6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity:
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate.
UniProtKB/Swiss-Prot Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Enzyme Numbers (IUBMB) for PGLS Gene

Phenotypes From GWAS Catalog for PGLS Gene

Gene Ontology (GO) - Molecular Function for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0017057 6-phosphogluconolactonase activity IDA,IEA 10518023
genes like me logo Genes that share ontologies with PGLS: view
genes like me logo Genes that share phenotypes with PGLS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGLS Gene

Localization for PGLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLS gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with PGLS: view

Pathways & Interactions for PGLS Gene

genes like me logo Genes that share pathways with PGLS: view

UniProtKB/Swiss-Prot O95336-6PGL_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Gene Ontology (GO) - Biological Process for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006098 pentose-phosphate shunt IEA,TAS --
GO:0009051 pentose-phosphate shunt, oxidative branch IBA --
genes like me logo Genes that share ontologies with PGLS: view

No data available for SIGNOR curated interactions for PGLS Gene

Drugs & Compounds for PGLS Gene

(5) Drugs for PGLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gluconolactone Approved, Experimental Pharma 0
Phenol Approved, Experimental Pharma 52
Water Approved Pharma 0
Magnesium Approved Nutra 0
6-Phosphogluconic acid Experimental Pharma 0

(1) Additional Compounds for PGLS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 6-(Dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-(9CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-D-Gluconic acid delta-lactone
  • 6-Pgdl
  • 6-Phospho-D-glucono-1,5-lactone
genes like me logo Genes that share compounds with PGLS: view

Transcripts for PGLS Gene

Unigene Clusters for PGLS Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGLS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PGLS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGLS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGLS Gene

mRNA differential expression in normal tissues according to GTEx for PGLS Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGLS Gene

Protein tissue co-expression partners for PGLS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGLS Gene:


SOURCE GeneReport for Unigene cluster for PGLS Gene:


Evidence on tissue expression from TISSUES for PGLS Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Adrenal gland(3)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with PGLS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLS Gene

Orthologs for PGLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGLS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGLS 33 34
  • 99.22 (n)
(Canis familiaris)
Mammalia PGLS 33 34
  • 88.89 (n)
(Bos Taurus)
Mammalia PGLS 33 34
  • 87.34 (n)
(Mus musculus)
Mammalia Pgls 33 16 34
  • 83.14 (n)
(Rattus norvegicus)
Mammalia Pgls 33
  • 82.23 (n)
(Monodelphis domestica)
Mammalia PGLS 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PGLS 34
  • 81 (a)
(Gallus gallus)
Aves BRD4 33 34
  • 70.28 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 83 (a)
-- 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgls 33
  • 62.52 (n)
(Danio rerio)
Actinopterygii pgls 33 34
  • 64.15 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10079 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010866 33
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17333 35 33 34
  • 53.75 (n)
(Caenorhabditis elegans)
Secernentea Y57G11C.3 34
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER268W 33
  • 46.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08415g 33
  • 42.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOL3 34 36
  • 34 (a)
SOL4 34
  • 32 (a)
SOL2 34
  • 28 (a)
SOL1 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGL1 33
  • 47.14 (n)
(Oryza sativa)
Liliopsida Os07g0604000 33
  • 51.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00087 33
  • 56.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC16C4.10 33
  • 45.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1252 34
  • 45 (a)
Species where no ortholog for PGLS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGLS Gene

Gene Tree for PGLS (if available)
Gene Tree for PGLS (if available)

Paralogs for PGLS Gene

(1) SIMAP similar genes for PGLS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGLS: view

No data available for Paralogs for PGLS Gene

Variants for PGLS Gene

Sequence variations from dbSNP and Humsavar for PGLS Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000048095 -- 17,511,895(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant
rs1000251487 -- 17,510,935(+) T/C upstream_transcript_variant
rs1000584236 -- 17,515,836(+) C/T intron_variant
rs1000655653 -- 17,517,614(+) T/C intron_variant
rs1000716747 -- 17,521,138(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PGLS Gene

Variant ID Type Subtype PubMed ID
nsv833768 CNV loss 17160897

Variation tolerance for PGLS Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLS Gene

Disorders for PGLS Gene

MalaCards: The human disease database

(2) MalaCards diseases for PGLS Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymph node disease
  • disorder of lymph node
lymphatic system disease
  • adenopathy
- elite association - COSMIC cancer census association via MalaCards
Search PGLS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PGLS

genes like me logo Genes that share disorders with PGLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLS Gene

Publications for PGLS Gene

  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). (PMID: 10518023) Collard F … Van Schaftingen E (FEBS letters 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for PGLS Gene

Sources for PGLS Gene

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