Aliases for PGLS Gene

Aliases for PGLS Gene

  • 6-Phosphogluconolactonase 2 3 4 5
  • 6PGL 2 3 4
  • EC 4 51
  • Epididymis Secretory Sperm Binding Protein 3
  • Epididymis Secretory Protein Li 304 3
  • HEL-S-304 3
  • PGLS 5

External Ids for PGLS Gene

Previous GeneCards Identifiers for PGLS Gene

  • GC19P018116
  • GC19P018014
  • GC19P017467
  • GC19P017484
  • GC19P017485
  • GC19P017486
  • GC19P017622
  • GC19P017189
  • GC19P017556
  • GC19P017702
  • GC19P020476
  • GC19P020618
  • GC19P020724
  • GC19P022233
  • GC19P017726
  • GC19P018301
  • GC19P018693
  • GC19P019003
  • GC19P019323
  • GC19P019658
  • GC19P020016
  • GC19P020331

Summaries for PGLS Gene

GeneCards Summary for PGLS Gene

PGLS (6-Phosphogluconolactonase) is a Protein Coding gene. Diseases associated with PGLS include Persistent Generalized Lymphadenopathy and Plethora Of Newborn. Among its related pathways are Pentose phosphate pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include monosaccharide binding and 6-phosphogluconolactonase activity.

UniProtKB/Swiss-Prot Summary for PGLS Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGLS Gene

Genomics for PGLS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PGLS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGLS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGLS

Top Transcription factor binding sites by QIAGEN in the PGLS gene promoter:
  • AREB6
  • Arnt
  • ATF6
  • CUTL1
  • E47
  • HEN1
  • Lmo2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5A

Genomic Locations for PGLS Gene

Genomic Locations for PGLS Gene
9,656 bases
Plus strand
9,666 bases
Plus strand

Genomic View for PGLS Gene

Genes around PGLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLS Gene

Proteins for PGLS Gene

  • Protein details for PGLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for PGLS Gene

    258 amino acids
    Molecular mass:
    27547 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72960.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PGLS Gene

Selected DME Specific Peptides for PGLS Gene


Post-translational modifications for PGLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGLS Gene

Antibody Products

  • Abcam antibodies for PGLS
  • Boster Bio Antibodies for PGLS

Domains & Families for PGLS Gene

Gene Families for PGLS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PGLS Gene

GenScript: Design optimal peptide antigens:
  • 6-phosphogluconolactonase (6PGL_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
genes like me logo Genes that share domains with PGLS: view

Function for PGLS Gene

Molecular function for PGLS Gene

UniProtKB/Swiss-Prot Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=;.
GENATLAS Biochemistry:
6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway

Enzyme Numbers (IUBMB) for PGLS Gene

Phenotypes From GWAS Catalog for PGLS Gene

Gene Ontology (GO) - Molecular Function for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0017057 6-phosphogluconolactonase activity IEA,IDA 10518023
genes like me logo Genes that share ontologies with PGLS: view
genes like me logo Genes that share phenotypes with PGLS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGLS Gene

Localization for PGLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLS gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
plasma membrane 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PGLS: view

Pathways & Interactions for PGLS Gene

genes like me logo Genes that share pathways with PGLS: view

UniProtKB/Swiss-Prot O95336-6PGL_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Gene Ontology (GO) - Biological Process for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006098 pentose-phosphate shunt IEA,TAS --
GO:0009051 pentose-phosphate shunt, oxidative branch IBA 21873635
genes like me logo Genes that share ontologies with PGLS: view

No data available for SIGNOR curated interactions for PGLS Gene

Drugs & Compounds for PGLS Gene

(5) Drugs for PGLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gluconolactone Approved, Experimental Pharma 0
Magnesium Approved, Experimental, Investigational Pharma 0
Phenol Approved, Experimental Pharma 69
Water Approved Pharma 0
6-Phosphogluconic acid Experimental Pharma 0

(1) Additional Compounds for PGLS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 6-phospho-D-glucono-1,5-Lactone
  • 6-phosphonoglucono-delta-Lactone
  • [(2R,3S,4S,5R)-3,4,5-Trihydroxy-6-oxotetrahydro-2H-pyran-2-yl]methyl dihydrogen phosphate
  • D-Gluconic acid, delta-lactone, 6-(dihydrogen phosphate)
  • D-glucono-1,5-Lactone 6-phosphate
genes like me logo Genes that share compounds with PGLS: view

Transcripts for PGLS Gene

mRNA/cDNA for PGLS Gene

7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGLS

Alternative Splicing Database (ASD) splice patterns (SP) for PGLS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PGLS Gene

GeneLoc Exon Structure for

Expression for PGLS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGLS Gene

mRNA differential expression in normal tissues according to GTEx for PGLS Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGLS Gene

Protein tissue co-expression partners for PGLS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGLS

SOURCE GeneReport for Unigene cluster for PGLS Gene:


Evidence on tissue expression from TISSUES for PGLS Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Adrenal gland(3.2)
  • Blood(2.8)
  • Skin(2.7)
  • Lymph node(2.5)
  • Stomach(2.3)
  • Intestine(2.3)
  • Thyroid gland(2.3)
  • Lung(2.2)
  • Kidney(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PGLS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLS Gene

Orthologs for PGLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGLS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGLS 30 31
  • 99.22 (n)
(Canis familiaris)
Mammalia PGLS 30 31
  • 88.89 (n)
(Bos Taurus)
Mammalia PGLS 30 31
  • 87.34 (n)
(Mus musculus)
Mammalia Pgls 30 17 31
  • 83.14 (n)
(Rattus norvegicus)
Mammalia Pgls 30
  • 82.23 (n)
(Monodelphis domestica)
Mammalia PGLS 31
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PGLS 31
  • 81 (a)
(Gallus gallus)
Aves BRD4 30 31
  • 70.28 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 83 (a)
-- 31
  • 73 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pgls 30
  • 62.52 (n)
(Danio rerio)
Actinopterygii pgls 30 31
  • 64.15 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10079 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010866 30
  • 54.05 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17333 30 31 32
  • 53.75 (n)
(Caenorhabditis elegans)
Secernentea Y57G11C.3 31
  • 31 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER268W 30
  • 46.33 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08415g 30
  • 42.83 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOL3 31 33
  • 34 (a)
SOL4 31
  • 32 (a)
SOL2 31
  • 28 (a)
SOL1 31
  • 26 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PGL1 30
  • 47.14 (n)
(Oryza sativa)
Liliopsida Os07g0604000 30
  • 51.35 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00087 30
  • 56.14 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC16C4.10 30
  • 45.36 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1252 31
  • 45 (a)
Species where no ortholog for PGLS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PGLS Gene

Gene Tree for PGLS (if available)
Gene Tree for PGLS (if available)
Evolutionary constrained regions (ECRs) for PGLS: view image

Paralogs for PGLS Gene

(1) SIMAP similar genes for PGLS Gene using alignment to 4 proteins:

  • M0R0U3_HUMAN
  • M0R1L2_HUMAN
  • M0R261_HUMAN
genes like me logo Genes that share paralogs with PGLS: view

No data available for Paralogs for PGLS Gene

Variants for PGLS Gene

Additional dbSNP identifiers (rs#s) for PGLS Gene

Structural Variations from Database of Genomic Variants (DGV) for PGLS Gene

Variant ID Type Subtype PubMed ID
nsv833768 CNV loss 17160897

Variation tolerance for PGLS Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGLS Gene

Disorders for PGLS Gene

MalaCards: The human disease database

(18) MalaCards diseases for PGLS Gene - From: DISEASES

Disorder Aliases PubMed IDs
persistent generalized lymphadenopathy
  • pgl
plethora of newborn
  • neonatal polycythemia
lymph node disease
  • disorder of lymph node
extra-adrenal pheochromocytoma
  • pheochromocytoma, extra-adrenal
paraganglioma and gastric stromal sarcoma
  • carney-stratakis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PGLS in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PGLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLS Gene

Publications for PGLS Gene

  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). (PMID: 10518023) Collard F … Van Schaftingen E (FEBS letters 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3
  5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. (PMID: 31536960) Moutaoufik MT … Babu M (iScience 2019) 3

Products for PGLS Gene

Sources for PGLS Gene