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This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
PGK2 (Phosphoglycerate Kinase 2) is a Protein Coding gene. Diseases associated with PGK2 include Phosphoglycerate Kinase 1 Deficiency and Testicular Torsion. Among its related pathways are Glucose metabolism and Cori Cycle. Gene Ontology (GO) annotations related to this gene include phosphoglycerate kinase activity. An important paralog of this gene is PGK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004618 | phosphoglycerate kinase activity | IBA,NAS | 3453121 |
GO:0005524 | ATP binding | IBA,ISS | -- |
GO:0016301 | kinase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0035686 | sperm fibrous sheath | IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
|
.46
|
2 | Carbon metabolism | ||
3 | Metabolism |
.40
|
|
4 | HIF-1 signaling pathway | ||
5 | Glycosaminoglycan metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006094 | gluconeogenesis | IBA | 21873635 |
GO:0006096 | glycolytic process | IBA,NAS | 3453121 |
GO:0016310 | phosphorylation | NAS | 3453121 |
GO:1903862 | positive regulation of oxidative phosphorylation | IBA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Phosphoglyceric acid |
|
2553-59-5 |
|
|||
ADP |
|
58-64-0 |
|
|||
Glyceric acid 1,3-biphosphate |
|
38168-82-0 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PGK2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PGK2 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | PGK2 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Pgk2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pgk2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | PGK1 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | pgk1 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Pgk 31 32 |
|
ManyToMany | |
CG9961 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pgk-1 31 |
|
OneToMany | |
T03F1.3 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PGK1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PGK 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6705 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.6263 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0169300 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3608949 | CNV | loss | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
phosphoglycerate kinase 1 deficiency |
|
|
testicular torsion |
|
|