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Aliases for PGGT1B Gene

Aliases for PGGT1B Gene

  • Protein Geranylgeranyltransferase Type I Subunit Beta 2 3 5
  • Protein Geranylgeranyltransferase Type I, Beta Subunit 2 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Beta 3 4
  • Geranylgeranyl Transferase Type I Subunit Beta 3 4
  • GGTase-I-Beta 3 4
  • EC 4 56
  • Geranylgeranyl Transferase Type-1 Subunit Beta 3
  • Geranylgeranyltransferase Type I Beta Subunit 3
  • CTC-428G20.3 3
  • EC 2.5.1 56
  • BGGI 3
  • GGTI 3

External Ids for PGGT1B Gene

Previous GeneCards Identifiers for PGGT1B Gene

  • GC05M114151
  • GC05M114950
  • GC05M114578
  • GC05M114623
  • GC05M114575
  • GC05M109728
  • GC05M114546

Summaries for PGGT1B Gene

Entrez Gene Summary for PGGT1B Gene

  • Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

GeneCards Summary for PGGT1B Gene

PGGT1B (Protein Geranylgeranyltransferase Type I Subunit Beta) is a Protein Coding gene. Among its related pathways are G-protein signaling_Rap1B regulation pathway and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include drug binding and protein geranylgeranyltransferase activity. An important paralog of this gene is RABGGTB.

UniProtKB/Swiss-Prot for PGGT1B Gene

  • Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Tocris Summary for PGGT1B Gene

Additional gene information for PGGT1B Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGGT1B Gene

Genomics for PGGT1B Gene

GeneHancer (GH) Regulatory Elements for PGGT1B Gene

Promoters and enhancers for PGGT1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I115261 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562 +0.3 265 2.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 PGGT1B ENSG00000271797 ATG12 CCDC112
GH05I115540 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.7 -280.3 -280258 5.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FEM1C SEMA6A-AS1 ENSG00000250015 ATG12 LOC101927100 TICAM2 PGGT1B TMED7-TICAM2 TMED7 CCT5P1
GH05I115838 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -579.2 -579239 6.3 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 ATG12 AP3S1 CDO1 ENSG00000250015 PGGT1B SEMA6A-AS1 GC05M115886
GH05I115815 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.2 -553.6 -553637 1.7 ZNF2 YY1 GLIS2 ZNF213 ZNF263 SP3 MXD4 REST ZNF518A GLIS1 CDO1 ATG12 PGGT1B GC05M115775 RNU2-49P
GH05I115927 Enhancer 1.1 FANTOM5 ENCODE 9.8 -667.4 -667394 4.6 ZNF473 INSM2 KLF17 TCF12 ZNF23 ZNF366 SCRT2 ZNF416 ZNF207 FOS GC05M115931 ENSG00000250015 SEMA6A-AS1 ATG12 LVRN PGGT1B GC05M115886
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PGGT1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGGT1B gene promoter:

Genomic Locations for PGGT1B Gene

Genomic Locations for PGGT1B Gene
62,647 bases
Minus strand

Genomic View for PGGT1B Gene

Genes around PGGT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGGT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGGT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGGT1B Gene

Proteins for PGGT1B Gene

  • Protein details for PGGT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Geranylgeranyl transferase type-1 subunit beta
    Protein Accession:
    Secondary Accessions:
    • Q5MJP9

    Protein attributes for PGGT1B Gene

    377 amino acids
    Molecular mass:
    42368 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.

    Alternative splice isoforms for PGGT1B Gene


neXtProt entry for PGGT1B Gene

Selected DME Specific Peptides for PGGT1B Gene


Post-translational modifications for PGGT1B Gene

No Post-translational modifications

Other Protein References for PGGT1B Gene

Domains & Families for PGGT1B Gene

Gene Families for PGGT1B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PGGT1B Gene

Suggested Antigen Peptide Sequences for PGGT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein prenyltransferase subunit beta family.
  • Belongs to the protein prenyltransferase subunit beta family.
genes like me logo Genes that share domains with PGGT1B: view

Function for PGGT1B Gene

Molecular function for PGGT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Enzyme Numbers (IUBMB) for PGGT1B Gene

Phenotypes From GWAS Catalog for PGGT1B Gene

Gene Ontology (GO) - Molecular Function for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004659 prenyltransferase activity IEA --
GO:0004661 protein geranylgeranyltransferase activity IDA 16893176
GO:0004662 CAAX-protein geranylgeranyltransferase activity TAS,ISS --
GO:0008144 drug binding IEA --
GO:0008270 zinc ion binding ISS --
genes like me logo Genes that share ontologies with PGGT1B: view
genes like me logo Genes that share phenotypes with PGGT1B: view

Animal Models for PGGT1B Gene

MGI Knock Outs for PGGT1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PGGT1B Gene

Localization for PGGT1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGGT1B gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005953 CAAX-protein geranylgeranyltransferase complex IDA,TAS 16893176
genes like me logo Genes that share ontologies with PGGT1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PGGT1B Gene

Pathways & Interactions for PGGT1B Gene

genes like me logo Genes that share pathways with PGGT1B: view

Gene Ontology (GO) - Biological Process for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0018344 protein geranylgeranylation IDA,TAS 16893176
GO:0034097 response to cytokine IEA --
GO:0045787 positive regulation of cell cycle IEA --
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA --
genes like me logo Genes that share ontologies with PGGT1B: view

No data available for SIGNOR curated interactions for PGGT1B Gene

Drugs & Compounds for PGGT1B Gene

(6) Drugs for PGGT1B Gene - From: DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma Competitive, Inhibitor 154
geranylgeranyl diphosphate Experimental Pharma Feedback inhibition, Inhibitor, Target 0
GGTI-2418 Pharma 0

(3) Additional Compounds for PGGT1B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-trans,6-trans,10-trans-Geranylgeranyl diphosphate
  • 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl diphosphate
  • All-trans-geranyl-geranyl-pp
  • Geranylgeranyl-diphosphate
  • Geranylgeranyl-PP
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
FTI 277

(3) Tocris Compounds for PGGT1B Gene

Compound Action Cas Number
FTI 277 Prodrug form of FTI 276 (Cat. No. 2406) 1217447-06-7
GGTI 298 Geranylgeranyltransferase I (GGTase I) inhibitor 1217457-86-7
LB 42708 Selective farnesyltransferase (FTase) inhibitor 226929-39-1
genes like me logo Genes that share compounds with PGGT1B: view

Transcripts for PGGT1B Gene

Unigene Clusters for PGGT1B Gene

Protein geranylgeranyltransferase type I, beta subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGGT1B Gene

No ASD Table

Relevant External Links for PGGT1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGGT1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGGT1B Gene

Protein differential expression in normal tissues from HIPED for PGGT1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.6) and Spleen (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGGT1B Gene

Protein tissue co-expression partners for PGGT1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGGT1B Gene:


SOURCE GeneReport for Unigene cluster for PGGT1B Gene:


Evidence on tissue expression from TISSUES for PGGT1B Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with PGGT1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGGT1B Gene

Orthologs for PGGT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGGT1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGGT1B 33 34
  • 99.65 (n)
(Monodelphis domestica)
Mammalia PGGT1B 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia PGGT1B 34
  • 95 (a)
(Canis familiaris)
Mammalia PGGT1B 33 34
  • 94.08 (n)
(Bos Taurus)
Mammalia PGGT1B 33 34
  • 92.48 (n)
(Rattus norvegicus)
Mammalia Pggt1b 33
  • 89.92 (n)
(Mus musculus)
Mammalia Pggt1b 33 16 34
  • 87.18 (n)
(Gallus gallus)
Aves PGGT1B 33 34
  • 82.01 (n)
(Anolis carolinensis)
Reptilia PGGT1B 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pggt1b 33
  • 74.84 (n)
Str.1329 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4454 33
(Danio rerio)
Actinopterygii pggt1b 33 34
  • 65.71 (n)
Dr.10651 33
fruit fly
(Drosophila melanogaster)
Insecta betaggt-I 33 34
  • 51.55 (n)
bgrggt-I 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008406 33
  • 51.46 (n)
(Caenorhabditis elegans)
Secernentea Y48E1B.3 33 34
  • 51.13 (n)
csp-1 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET2 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGGT-I 33
  • 51.04 (n)
(Oryza sativa)
Liliopsida Os01g0150100 33
  • 52.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3753 34
  • 51 (a)
Species where no ortholog for PGGT1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGGT1B Gene

Gene Tree for PGGT1B (if available)
Gene Tree for PGGT1B (if available)

Paralogs for PGGT1B Gene

Paralogs for PGGT1B Gene Pseudogenes for PGGT1B Gene

genes like me logo Genes that share paralogs with PGGT1B: view

Variants for PGGT1B Gene

Sequence variations from dbSNP and Humsavar for PGGT1B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000008597 -- 115,215,653(-) C/T intron_variant
rs1000035071 -- 115,259,418(-) G/A/C intron_variant
rs1000068645 -- 115,253,580(-) T/C intron_variant
rs1000073613 -- 115,226,199(-) C/A intron_variant
rs1000091077 -- 115,221,207(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PGGT1B Gene

Variant ID Type Subtype PubMed ID
nsv980715 CNV duplication 23825009
nsv830454 CNV gain+loss 17160897
nsv830453 CNV gain 17160897
nsv478622 CNV novel sequence insertion 20440878
nsv1029371 CNV loss 25217958
esv3566493 CNV deletion 23714750

Variation tolerance for PGGT1B Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGGT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGGT1B Gene

Disorders for PGGT1B Gene

Additional Disease Information for PGGT1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PGGT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGGT1B Gene

Publications for PGGT1B Gene

  1. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. (PMID: 8106351) Zhang FL … Omer CA (The Journal of biological chemistry 1994) 2 3 4 58
  2. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PMID: 19667218) Comabella M … Montalban X (Archives of neurology 2009) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion. (PMID: 23475391) Zhou X … Yu R (Journal of neuro-oncology 2013) 3 58

Products for PGGT1B Gene

Sources for PGGT1B Gene

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