Aliases for PGAM1 Gene
External Ids for PGAM1 Gene
Previous HGNC Symbols for PGAM1 Gene
Previous GeneCards Identifiers for PGAM1 Gene
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for PGAM1 Gene
PGAM1 (Phosphoglycerate Mutase 1) is a Protein Coding gene. Diseases associated with PGAM1 include Menkes Disease and Myoglobinuria. Among its related pathways are Glucose metabolism and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and bisphosphoglycerate mutase activity. An important paralog of this gene is PGAM4.
UniProtKB/Swiss-Prot Summary for PGAM1 Gene
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 22.214.171.124 (synthase), but with a reduced activity.