PGA5 Gene (Protein Coding)

Pepsinogen A5

GC11P061241
GIFtS:
34
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromos... See more...

Aliases for PGA5 Gene

Aliases for PGA5 Gene

  • Pepsinogen A5 2 3 5
  • Pepsinogen 5, Group I (Pepsinogen A) 2 3
  • Pepsinogen-5 3 4
  • Pepsin A-5 3 4
  • Pepsin A 2 3
  • Pepsinogen-4 3
  • EC 3.4.23.1 4
  • Pepsin A-4 3
  • PGA5 5
  • Pg5 3

External Ids for PGA5 Gene

Previous GeneCards Identifiers for PGA5 Gene

  • GC11U990102
  • GC11P062521
  • GC11P061259
  • GC11P060786
  • GC11P060788
  • GC11P060767
  • GC11P060991
  • GC11P061008

Summaries for PGA5 Gene

Entrez Gene Summary for PGA5 Gene

  • This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

GeneCards Summary for PGA5 Gene

PGA5 (Pepsinogen A5) is a Protein Coding gene. Diseases associated with PGA5 include Atrophic Gastritis and Gastritis. Among its related pathways are Surfactant metabolism and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA4.

UniProtKB/Swiss-Prot Summary for PGA5 Gene

  • Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Gene Wiki entry for PGA5 Gene

Additional gene information for PGA5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PGA5 Gene

Genomics for PGA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PGA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J061240 Promoter/Enhancer 0.7 EPDnew Ensembl 250.7 -0.1 -74 3 EZH2 ZNF512 PRDM1 HSALNG0084505-002 PGA5 HSALNG0084506 piR-45035-036 ENSG00000256220 PGA4
GH11J061221 Promoter/Enhancer 0.7 EPDnew Ensembl dbSUPER 250.4 -19.0 -18975 3.2 HSALNG0084505-001 PGA4 PGA5 piR-45035-035 PGA3 HSALNG0084505-002
GH11J061293 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +53.4 53426 3.2 BCLAF1 ZNF600 SSRP1 ATF2 KLF9 POLR2A ZIC2 ZBTB10 YY1 MXD4 HSALNG0084512-001 HSALNG0084512-002 VWCE piR-51671-010 PGA5
GH11J061254 Enhancer 0.9 Ensembl ENCODE 0.4 +13.4 13409 0.7 ZNF654 REST DEK TRIM22 CTCF RAD21 SMC3 EBF1 RBM22 SMARCA5 lnc-PGA5-1 VWCE DDB1 TMEM216 TKFC CD6 HSALNG0084508 PGA5
GH11J061265 Enhancer 0.7 ENCODE 0.4 +24.3 24316 0.8 CEBPA CHD4 FOXA2 SMAD4 RXRA RARA ZSCAN9 ZBTB33 THRB FOSL2 VWCE DDB1 TKFC lnc-DDB1-4 piR-41406-011 PGA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PGA5

Top Transcription factor binding sites by QIAGEN in the PGA5 gene promoter:
  • CP2
  • FOXD1

Genomic Locations for PGA5 Gene

Latest Assembly
chr11:61,241,175-61,251,444
(GRCh38/hg38)
Size:
10,270 bases
Orientation:
Plus strand

Previous Assembly
chr11:61,008,647-61,018,916
(GRCh37/hg19 by Entrez Gene)
Size:
10,270 bases
Orientation:
Plus strand

chr11:61,008,514-61,018,920
(GRCh37/hg19 by Ensembl)
Size:
10,407 bases
Orientation:
Plus strand

Genomic View for PGA5 Gene

Genes around PGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGA5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PGA5 Gene

Proteins for PGA5 Gene

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  • Protein details for PGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJD9-PEPA5_HUMAN
    Recommended name:
    Pepsin A-5
    Protein Accession:
    P0DJD9
    Secondary Accessions:
    • A8K749
    • B7ZW62
    • B7ZW75
    • P00790
    • Q7M4R0
    • Q8N1E3

    Protein attributes for PGA5 Gene

    Size:
    388 amino acids
    Molecular mass:
    41993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PGA5 Gene

Protein Expression for PGA5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PGA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGA5 Gene

Domains & Families for PGA5 Gene

Gene Families for PGA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PGA5 Gene

InterPro:

Suggested Antigen Peptide Sequences for PGA5 Gene

GenScript: Design optimal peptide antigens:
  • Pepsinogen 5, group I (Pepsinogen A) (B7ZW66_HUMAN)
  • Pepsin A (PEPA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DJD9

UniProtKB/Swiss-Prot:

PEPA5_HUMAN :
  • Belongs to the peptidase A1 family.
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGA5: view

Function for PGA5 Gene

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  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for PGA5 Gene

UniProtKB/Swiss-Prot Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10094};.
GENATLAS Biochemistry:
pepsinogen 5,group I (pepsinogen A),clustered with PGA3,PGA4

Enzyme Numbers (IUBMB) for PGA5 Gene

Phenotypes From GWAS Catalog for PGA5 Gene

Gene Ontology (GO) - Molecular Function for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PGA5: view
genes like me logo Genes that share phenotypes with PGA5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGA5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGA5 Gene

Localization for PGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGA5 gene
Compartment Confidence
extracellular 5
endosome 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 23533145
GO:0097486 multivesicular body lumen TAS --
genes like me logo Genes that share ontologies with PGA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PGA5 Gene

Pathways & Interactions for PGA5 Gene

genes like me logo Genes that share pathways with PGA5: view

Pathways by source for PGA5 Gene

2 Reactome pathways for PGA5 Gene
1 KEGG pathway for PGA5 Gene

Interacting Proteins for PGA5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000309542 for PGA5 Gene via STRING

GPS-Prot Interaction Network for PGA5

Gene Ontology (GO) - Biological Process for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PGA5: view

No data available for SIGNOR curated interactions for PGA5 Gene

Drugs & Compounds for PGA5 Gene

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(1) Drugs for PGA5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucralfate Approved Pharma Target, inhibitor 15
genes like me logo Genes that share compounds with PGA5: view

Transcripts for PGA5 Gene

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mRNA/cDNA for PGA5 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PGA5

Alternative Splicing Database (ASD) splice patterns (SP) for PGA5 Gene

No ASD Table

Relevant External Links for PGA5 Gene

GeneLoc Exon Structure for
PGA5

Expression for PGA5 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGA5 Gene

mRNA expression in normal human tissues for PGA5 Gene
mRNA expression by BioGPS for PGA5 GenemRNA expression by GTEx for PGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGA5 Gene

This gene is overexpressed in Stomach (x52.9).

Protein differential expression in normal tissues from HIPED for PGA5 Gene

This gene is overexpressed in Urine (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGA5 Gene



Protein tissue co-expression partners for PGA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PGA5

SOURCE GeneReport for Unigene cluster for PGA5 Gene:

Hs.432854

Evidence on tissue expression from TISSUES for PGA5 Gene

  • Nervous system(4.4)
  • Stomach(4.3)
  • Kidney(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PGA5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGA5 Gene

Orthologs for PGA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PGA4 29
  • 99.05 (n)
-- 30
  • 99 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia PGA 29 30
  • 85.66 (n)
 OneToMany
Cow
(Bos Taurus)
 Mammalia PGA5 29
  • 84.54 (n)
PGA 30
  • 82 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 51 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves LOC395926 29
  • 63.34 (n)
PGA 30
  • 62 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 72 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia pga4 29
  • 67.71 (n)
African clawed frog
(Xenopus laevis)
 Amphibia pga-A 29
Species where no ortholog for PGA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PGA5 Gene

ENSEMBL:
Gene Tree for PGA5 (if available)
TreeFam:
Gene Tree for PGA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PGA5: view image
Alliance of Genome Resources:
Additional Orthologs for PGA5

Paralogs for PGA5 Gene

Paralogs for PGA5 Gene

(8) SIMAP similar genes for PGA5 Gene using alignment to 4 proteins:

  • PEPA5_HUMAN
  • B7ZW66_HUMAN
  • C9JM59_HUMAN
  • F5GWT0_HUMAN
genes like me logo Genes that share paralogs with PGA5: view

Variants for PGA5 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PGA5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PGA5 Gene

Variant ID Type Subtype PubMed ID
esv2744587 CNV deletion 23290073
esv2759831 CNV gain+loss 17122850
esv29298 CNV gain+loss 19812545
esv3350259 CNV duplication 20981092
esv3353952 CNV duplication 20981092
esv3425930 CNV duplication 20981092
esv3579734 CNV loss 25503493
esv3626575 CNV loss 21293372
esv3626576 CNV gain 21293372
nsv1118213 CNV deletion 24896259
nsv339 CNV deletion 18451855
nsv341 CNV insertion 18451855
nsv428259 CNV gain+loss 18775914
nsv514629 CNV gain 21397061
nsv555162 CNV loss 21841781
nsv820586 CNV deletion 20802225
nsv825937 CNV loss 20364138
nsv832177 CNV loss 17160897
nsv8833 CNV gain 18304495
nsv952458 CNV duplication 24416366
nsv975192 CNV duplication 23825009

Variation tolerance for PGA5 Gene

Gene Damage Index Score: 2.18; 39.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGA5
Leiden Open Variation Database (LOVD)
PGA5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PGA5 Gene

Disorders for PGA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PGA5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
atrophic gastritis
  • gastric atrophy
gastritis
  • acute gastric mucosal erosion
chief cell adenoma
  • chief cell adenoma of parathyroid gland
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PGA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PGA5

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PGA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGA5 Gene

Publications for PGA5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Crystal structure of human pepsin and its complex with pepstatin. (PMID: 7663352) Fujinaga M … James MN (Protein science : a publication of the Protein Society 1995) 3 4
  3. A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. (PMID: 2515193) Athauda SB … Takahashi K (Journal of biochemistry 1989) 3 4
  4. Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. (PMID: 2714789) Evers MP … Eriksson AW (Genomics 1989) 3 4
  5. Activation of human pepsinogens. (PMID: 3197840) Foltmann B (FEBS letters 1988) 3 4

ExternalLinks

View latest publications for PGA5 gene in Mastermind

Products for PGA5 Gene

Sources for PGA5 Gene