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This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
PGA4 (Pepsinogen A4) is a Protein Coding gene. Diseases associated with PGA4 include Gastritis. Among its related pathways are Collagen chain trimerization and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J061221 | Promoter/Enhancer | 0.7 | EPDnew Ensembl dbSUPER | 750.6 | 0.0 | -16 | 3.2 | PGA4 PGA5 piR-45035-035 | ||
GH11J061217 | Enhancer | 0.3 | Ensembl dbSUPER | 0.6 | -4.1 | -4069 | 1.7 | PGA4 piR-45035-035 | ||
GH11J061212 | Enhancer | 0.3 | Ensembl dbSUPER | 0.4 | -7.9 | -7915 | 2.2 | piR-45035-035 PGA4 | ||
GH11J061227 | Enhancer | 0.3 | Ensembl dbSUPER | 0.4 | +5.3 | 5285 | 5 | ENSG00000256220 piR-45035-036 PGA4 | ||
GH11J061231 | Enhancer | 0.3 | Ensembl dbSUPER | 0.4 | +10.8 | 10785 | 2.4 | piR-45035-036 ENSG00000256220 PGA5 PGA4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004190 | aspartic-type endopeptidase activity | IBA | 21873635 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
GO:0097486 | multivesicular body lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization | ||
2 | Metabolism of proteins | ||
3 | Surfactant metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA,IBA | 21873635 |
GO:0007586 | digestion | IEA | -- |
GO:0030163 | protein catabolic process | IBA | 21873635 |
GO:0044267 | cellular protein metabolic process | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PGA4 32 |
|
||
-- 33 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | PGA 33 32 |
|
OneToMany | |
cow (Bos Taurus) |
Mammalia | PGA5 32 |
|
||
PGA 33 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Cym 33 |
|
ManyToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | LOC395926 32 |
|
||
PGA 33 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pga4 32 |
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1003927024 | -- | 61,221,636(+) | T/A | upstream_transcript_variant | |
rs1014015090 | -- | 61,230,954(+) | C/G | intron_variant | |
rs1015851097 | -- | 61,230,061(+) | G/A | coding_sequence_variant, missense_variant | |
rs1033619332 | -- | 61,230,520(+) | T/ | intron_variant | |
rs1039301952 | -- | 61,221,250(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1960n54 | CNV | loss | 21841781 |
dgv1961n54 | CNV | loss | 21841781 |
esv1004439 | CNV | deletion | 20482838 |
esv2744587 | CNV | deletion | 23290073 |
esv2759831 | CNV | gain+loss | 17122850 |
esv2761679 | CNV | loss | 21179565 |
esv29298 | CNV | gain+loss | 19812545 |
esv3350259 | CNV | duplication | 20981092 |
esv3382959 | CNV | duplication | 20981092 |
esv3425930 | CNV | duplication | 20981092 |
esv3579734 | CNV | loss | 25503493 |
nsv1115412 | CNV | duplication | 24896259 |
nsv1118213 | CNV | deletion | 24896259 |
nsv339 | CNV | deletion | 18451855 |
nsv340 | CNV | insertion | 18451855 |
nsv428259 | CNV | gain+loss | 18775914 |
nsv509414 | CNV | insertion | 20534489 |
nsv514629 | CNV | gain | 21397061 |
nsv555162 | CNV | loss | 21841781 |
nsv555163 | CNV | loss | 21841781 |
nsv820586 | CNV | deletion | 20802225 |
nsv825937 | CNV | loss | 20364138 |
nsv832176 | CNV | gain+loss | 17160897 |
nsv832177 | CNV | loss | 17160897 |
nsv8833 | CNV | gain | 18304495 |
nsv952458 | CNV | duplication | 24416366 |
nsv975192 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastritis |
|
|