Aliases for PGA4 Gene
External Ids for PGA4 Gene
Previous GeneCards Identifiers for PGA4 Gene
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
GeneCards Summary for PGA4 Gene
PGA4 (Pepsinogen A4) is a Protein Coding gene. Diseases associated with PGA4 include Atrophic Gastritis and Gastritis. Among its related pathways are Collagen chain trimerization and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA5.
UniProtKB/Swiss-Prot Summary for PGA4 Gene
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.