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Aliases for PGA4 Gene

Aliases for PGA4 Gene

  • Pepsinogen 4, Group I (Pepsinogen A) 2 3 5
  • Pepsinogen-4 3 4
  • Pregnancy-Associated Glycoprotein 3
  • Pepsinogen A4 3
  • EC 4
  • Pepsin A-4 3

External Ids for PGA4 Gene

Previous GeneCards Identifiers for PGA4 Gene

  • GC11U990101
  • GC11P060765
  • GC11P060727
  • GC11P060747
  • GC11P060739
  • GC11P060989

Summaries for PGA4 Gene

Entrez Gene Summary for PGA4 Gene

  • This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

GeneCards Summary for PGA4 Gene

PGA4 (Pepsinogen 4, Group I (Pepsinogen A)) is a Protein Coding gene. Diseases associated with PGA4 include Atrophic Gastritis and Gastritis. Among its related pathways are Collagen chain trimerization and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA3.

UniProtKB/Swiss-Prot for PGA4 Gene

  • Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Additional gene information for PGA4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGA4 Gene

Genomics for PGA4 Gene

GeneHancer (GH) Regulatory Elements for PGA4 Gene

Promoters and enhancers for PGA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I061222 Enhancer 0.2 Ensembl 550.8 +0.3 285 0.2 PGA4 ENSG00000256220
GH11I061221 Enhancer 0.2 dbSUPER 550.8 -0.5 -530 0.4 PGA4 PGA3
GH11I061217 Enhancer 0.2 dbSUPER 0.8 -4.2 -4166 1.4 PGA4 PGA3
GH11I061203 Enhancer 0.4 Ensembl 0.4 -18.7 -18715 0.2 ZNF366 ZNF512 PGA3 PGA4
GH11I061228 Enhancer 0.2 dbSUPER 0.4 +6.3 6267 0.4 ENSG00000256220 PGA4 PGA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PGA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGA4 gene promoter:

Genomic Locations for PGA4 Gene

Genomic Locations for PGA4 Gene
9,712 bases
Plus strand

Genomic View for PGA4 Gene

Genes around PGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGA4 Gene

Proteins for PGA4 Gene

  • Protein details for PGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pepsin A-4
    Protein Accession:
    Secondary Accessions:
    • A8K749
    • B7ZW75
    • P00790
    • Q7M4R0
    • Q8N1E3

    Protein attributes for PGA4 Gene

    388 amino acids
    Molecular mass:
    41977 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PGA4 Gene

neXtProt entry for PGA4 Gene

Post-translational modifications for PGA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGA4 Gene

No data available for DME Specific Peptides for PGA4 Gene

Domains & Families for PGA4 Gene

Gene Families for PGA4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGA4: view

Function for PGA4 Gene

Molecular function for PGA4 Gene

GENATLAS Biochemistry:
pepsinogen 4,group I (pepsinogen A),clustered with PGA3,PGA5
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1 positions. Cleaves 1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly- -Phe-24, 24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin.
UniProtKB/Swiss-Prot Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Enzyme Numbers (IUBMB) for PGA4 Gene

Gene Ontology (GO) - Molecular Function for PGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IBA --
GO:0008233 peptidase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PGA4: view
genes like me logo Genes that share phenotypes with PGA4: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGA4 Gene

Localization for PGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGA4 gene
Compartment Confidence
extracellular 5
endosome 4

Gene Ontology (GO) - Cellular Components for PGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
GO:0097486 multivesicular body lumen TAS --
genes like me logo Genes that share ontologies with PGA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PGA4 Gene

Pathways & Interactions for PGA4 Gene

genes like me logo Genes that share pathways with PGA4: view

Pathways by source for PGA4 Gene

2 Reactome pathways for PGA4 Gene
1 KEGG pathway for PGA4 Gene

Gene Ontology (GO) - Biological Process for PGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IEA --
GO:0006914 autophagy IBA --
GO:0007586 digestion IEA --
GO:0030163 protein catabolic process IBA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PGA4: view

No data available for SIGNOR curated interactions for PGA4 Gene

Drugs & Compounds for PGA4 Gene

No Compound Related Data Available

Transcripts for PGA4 Gene

mRNA/cDNA for PGA4 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGA4 Gene

Pepsinogen 4, group I (pepsinogen A):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGA4 Gene

No ASD Table

Relevant External Links for PGA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGA4 Gene

This gene is overexpressed in Stomach (x52.6).

NURSA nuclear receptor signaling pathways regulating expression of PGA4 Gene:


SOURCE GeneReport for Unigene cluster for PGA4 Gene:


Evidence on tissue expression from TISSUES for PGA4 Gene

  • Stomach(4.9)
  • Intestine(4.5)
  • Kidney(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with PGA4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGA4 Gene

Orthologs for PGA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGA4 33
  • 99.14 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia PGA 33 34
  • 86.1 (n)
(Bos Taurus)
Mammalia PGA5 33
  • 84.72 (n)
PGA 34
  • 82 (a)
(Mus musculus)
Mammalia Cym 34
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves LOC395926 33
  • 63.53 (n)
PGA 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pga4 33
  • 68.14 (n)
Species where no ortholog for PGA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PGA4 Gene

Gene Tree for PGA4 (if available)
Gene Tree for PGA4 (if available)

Paralogs for PGA4 Gene

Paralogs for PGA4 Gene

(8) SIMAP similar genes for PGA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PGA4: view

Variants for PGA4 Gene

Sequence variations from dbSNP and Humsavar for PGA4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1003927024 -- 61,221,636(+) T/A upstream_transcript_variant
rs1014015090 -- 61,230,954(+) C/G intron_variant
rs1015851097 -- 61,230,061(+) G/A coding_sequence_variant, missense_variant
rs1033619332 -- 61,230,520(+) T/ intron_variant
rs1039301952 -- 61,221,250(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PGA4 Gene

Variant ID Type Subtype PubMed ID
dgv1960n54 CNV loss 21841781
dgv1961n54 CNV loss 21841781
esv1004439 CNV deletion 20482838
esv2744587 CNV deletion 23290073
esv2759831 CNV gain+loss 17122850
esv2761679 CNV loss 21179565
esv29298 CNV gain+loss 19812545
esv3350259 CNV duplication 20981092
esv3382959 CNV duplication 20981092
esv3425930 CNV duplication 20981092
esv3579734 CNV loss 25503493
nsv1115412 CNV duplication 24896259
nsv1118213 CNV deletion 24896259
nsv339 CNV deletion 18451855
nsv340 CNV insertion 18451855
nsv428259 CNV gain+loss 18775914
nsv509414 CNV insertion 20534489
nsv514629 CNV gain 21397061
nsv555162 CNV loss 21841781
nsv555163 CNV loss 21841781
nsv820586 CNV deletion 20802225
nsv825937 CNV loss 20364138
nsv832176 CNV gain+loss 17160897
nsv832177 CNV loss 17160897
nsv8833 CNV gain 18304495
nsv952458 CNV duplication 24416366
nsv975192 CNV duplication 23825009

Variation tolerance for PGA4 Gene

Gene Damage Index Score: 0.06; 1.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGA4 Gene

Disorders for PGA4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PGA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atrophic gastritis
  • gastric atrophy
  • acute gastric mucosal erosion
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search PGA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PGA4

genes like me logo Genes that share disorders with PGA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGA4 Gene

Publications for PGA4 Gene

  1. Primary structure of human pepsinogen gene. (PMID: 6300126) Sogawa K … Takahashi K (The Journal of biological chemistry 1983) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Crystal structure of human pepsin and its complex with pepstatin. (PMID: 7663352) Fujinaga M … James MN (Protein science : a publication of the Protein Society 1995) 3 4 58
  4. A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. (PMID: 2515193) Athauda SB … Takahashi K (Journal of biochemistry 1989) 3 4 58
  5. Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. (PMID: 2714789) Evers MP … Eriksson AW (Genomics 1989) 3 4 58

Products for PGA4 Gene

Sources for PGA4 Gene

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