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This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
PGA3 (Pepsinogen A3) is a Protein Coding gene. Diseases associated with PGA3 include Atrophic Gastritis and Gastritis. Among its related pathways are Collagen chain trimerization and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J061202 | Promoter/Enhancer | 1 | EPDnew Ensembl dbSUPER | 769.1 | +2.2 | 2240 | 8.1 | ZBTB33 RNF2 ZNF512 ZNF316 ZNF366 EZH2 ZNF24 | PGA3 VPS37C CD6 RNU6-933P piR-45035-035 | |
GH11J061193 | Enhancer | 0.3 | dbSUPER | 13.4 | -9.4 | -9355 | 1.5 | FOXA1 | PGA3 CD5 CD6 TKFC DDB1 lnc-PGA3-1 | |
GH11J061198 | Enhancer | 0.2 | dbSUPER | 19 | -4.4 | -4351 | 0.9 | PGA3 CD6 lnc-PGA3-1 | ||
GH11J061505 | Enhancer | 0.5 | Ensembl | 5.1 | +302.6 | 302630 | 1.1 | GLIS2 ZIC2 PRDM10 ZBTB20 ZFHX2 ZNF335 FEZF1 GLIS1 ZNF398 | piR-43106-035 TMEM216 PGA3 ENSG00000255931 LOC105369329 | |
GH11J061187 | Enhancer | 0.6 | ENCODE | 0.4 | -15.6 | -15563 | 0.2 | CTCF MYC MAX RAD21 REST TRIM22 ZNF143 IRF3 RFX1 RUNX3 | VPS37C CD6 CCDC86 ENSG00000255959 lnc-PGA3-1 PGA3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004190 | aspartic-type endopeptidase activity | IBA | 21873635 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
GO:0097486 | multivesicular body lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Collagen chain trimerization | ||
2 | Metabolism of proteins | ||
3 | Surfactant metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IBA,IEA | 21873635 |
GO:0007586 | digestion | IEA | -- |
GO:0030163 | protein catabolic process | IBA | 21873635 |
GO:0044267 | cellular protein metabolic process | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PGA4 32 |
|
||
-- 33 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | PGA 33 32 |
|
OneToMany | |
cow (Bos Taurus) |
Mammalia | PGA5 32 |
|
||
PGA 33 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
mouse (Mus musculus) |
Mammalia | Pga5 33 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | LOC395926 32 |
|
||
PGA 33 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pga4 32 |
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1002371559 | -- | 61,202,961(+) | A/G | upstream_transcript_variant | |
rs1002402654 | -- | 61,203,786(+) | AAAA/AAA | intron_variant | |
rs1002738167 | -- | 61,201,875(+) | T/C | upstream_transcript_variant | |
rs1003991848 | -- | 61,201,732(+) | A/G | upstream_transcript_variant | |
rs1005745299 | -- | 61,202,438(+) | T/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1960n54 | CNV | loss | 21841781 |
esv1004439 | CNV | deletion | 20482838 |
esv2759831 | CNV | gain+loss | 17122850 |
esv2761679 | CNV | loss | 21179565 |
esv29298 | CNV | gain+loss | 19812545 |
esv3342315 | CNV | duplication | 20981092 |
esv3351352 | CNV | duplication | 20981092 |
esv3425930 | CNV | duplication | 20981092 |
esv3579734 | CNV | loss | 25503493 |
nsv1078324 | CNV | duplication | 25765185 |
nsv1118213 | CNV | deletion | 24896259 |
nsv1124641 | CNV | duplication | 24896259 |
nsv338 | CNV | insertion | 18451855 |
nsv339 | CNV | deletion | 18451855 |
nsv428259 | CNV | gain+loss | 18775914 |
nsv436823 | CNV | insertion | 17901297 |
nsv514629 | CNV | gain | 21397061 |
nsv555154 | CNV | gain | 21841781 |
nsv555155 | CNV | loss | 21841781 |
nsv555162 | CNV | loss | 21841781 |
nsv555163 | CNV | loss | 21841781 |
nsv72 | CNV | insertion | 15895083 |
nsv820586 | CNV | deletion | 20802225 |
nsv825937 | CNV | loss | 20364138 |
nsv832176 | CNV | gain+loss | 17160897 |
nsv832177 | CNV | loss | 17160897 |
nsv8833 | CNV | gain | 18304495 |
nsv952457 | CNV | duplication | 24416366 |
nsv975192 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
atrophic gastritis |
|
|
gastritis |
|
|