Aliases for PFKP Gene
External Ids for PFKP Gene
Previous GeneCards Identifiers for PFKP Gene
This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for PFKP Gene
PFKP (Phosphofructokinase, Platelet) is a Protein Coding gene. Diseases associated with PFKP include Glycogen Storage Disease Vii. Among its related pathways are Glucose metabolism and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include 6-phosphofructokinase activity. An important paralog of this gene is PFKM.
UniProtKB/Swiss-Prot for PFKP Gene
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.