Aliases for PFKFB4 Gene
Aliases for PFKFB4 Gene
External Ids for PFKFB4 Gene
- HGNC: 8875
- Entrez Gene: 5210
- Ensembl: ENSG00000114268
- OMIM: 605320
- UniProtKB: Q16877
Previous GeneCards Identifiers for PFKFB4 Gene
- GC03M048349
- GC03M047841
- GC03M048516
- GC03M048530
- GC03M048555
Summaries for PFKFB4 Gene
-
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for PFKFB4 Gene
PFKFB4 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4) is a Protein Coding gene. Among its related pathways are Fructose and mannose metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB1.
UniProtKB/Swiss-Prot for PFKFB4 Gene
-
Synthesis and degradation of fructose 2,6-bisphosphate.
Additional gene information for PFKFB4 Gene
- Monarch Initiative
- Search for PFKFB4 at DataMed
- Search for PFKFB4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFKFB4 Gene
Genomics for PFKFB4 Gene
GeneHancer (GH) Regulatory Elements for PFKFB4 Gene
Promoters and enhancers for PFKFB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PFKFB4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PFKFB4 gene promoter:
-
- AML1a
Genomic Locations for PFKFB4 Gene
Genomic Locations for PFKFB4 Gene
- chr3:48,517,684-48,562,774
- (GRCh38/hg38)
- Size:
- 45,091 bases
- Orientation:
- Minus strand
- chr3:48,555,117-48,599,448
- (GRCh37/hg19)
- Size:
- 44,332 bases
- Orientation:
- Minus strand
Genomic View for PFKFB4 Gene
Genes around PFKFB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by HGNC
- 3p21.31 by Entrez Gene
- 3p21.31 by Ensembl
PFKFB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PFKFB4 Gene
Proteins for PFKFB4 Gene
-
Protein details for PFKFB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16877-F264_HUMAN
- Recommended name:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
- Protein Accession:
- Q16877
- Q5S3G5
- Q5XLC2
- Q64EX5
Protein attributes for PFKFB4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 54040 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for PFKFB4 Gene
Post-translational modifications for PFKFB4 Gene
Other Protein References for PFKFB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-PFKFB4 Antibody (HPA066058) and Anti-PFKFB4 Antibody (HPA047719)
- GeneTex Anti-PFKFB4 antibody and Anti-PFKFB4 antibody [N3C3]
-
Custom Antibody ServicesOriGene Antibodies for PFKFB4
- Novus Biologicals Antibodies for PFKFB4
-
Abcam antibodies for PFKFB4
- Invitrogen Antibodies for PFKFB4 (AFLGC-PFKFB4)
-
Biorbyt antibodies for PFKFB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PFKFB4
Protein Products
- Atlas Antibodies PrEST Antigen PFKFB4 (APrEST88888) and PrEST Antigen PFKFB4 (APrEST91104)
-
OriGene Purified Proteins for PFKFB4
- Search Origene for MassSpec and Protein Over-expression Lysates for PFKFB4
- Origene Custom Protein Services for PFKFB4
- antibodies-online: Search results for 8 available PFKFB4 Proteins ranked by validation data
- Compare Top PFKFB4 Proteins
-
Quality Products:
-
Abcam proteins for PFKFB4
No data available for DME Specific Peptides for PFKFB4 Gene
Domains & Families for PFKFB4 Gene
Gene Families for PFKFB4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PFKFB4 Gene
Suggested Antigen Peptide Sequences for PFKFB4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58271, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (B7Z5C3_HUMAN)
- cDNA FLJ53771, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (B7Z5L3_HUMAN)
- 6PF-2-K/Fru-2,6-P2ase testis-type isozyme (F264_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16877UniProtKB/Swiss-Prot:
F264_HUMAN :- In the C-terminal section; belongs to the phosphoglycerate mutase family.
- Family:
-
- In the C-terminal section; belongs to the phosphoglycerate mutase family.
Function for PFKFB4 Gene
Molecular function for PFKFB4 Gene
- UniProtKB/Swiss-Prot Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+); Xref=Rhea:RHEA:15653, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579, ChEBI:CHEBI:456216; EC=2.7.1.105;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.
- GENATLAS Biochemistry:
- 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase bifunctional enzyme responsible for the synthesis and breakdown of fructose 2,6 biphosphate,key metabolite in the regulation of glycolysis,expressed in testis
Phenotypes From GWAS Catalog for PFKFB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0003873 | 6-phosphofructo-2-kinase activity | IEA,NAS | 10095107 |
| GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity | IBA | 21873635 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for PFKFB4 Gene
- MGI mutant phenotypes for PFKFB4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PFKFB4:
-
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased homologous recombination repair frequency
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Downregulation of NFkappaB pathway
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
Animal Models for PFKFB4 Gene
- MGI Knock Outs for PFKFB4:
-
- Pfkfb4 Pfkfb4<tm1b(KOMP)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for PFKFB4
- Cyagen custom Knockout/knockin (KOKI) mouse models for PFKFB4
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PFKFB4 - Now 50% OFF >
- * PFKFB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PFKFB4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for PFKFB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB4
- genomics-online: gRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB4
miRNA for PFKFB4 Gene
- miRTarBase miRNAs that target PFKFB4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PFKFB4
- Browse OriGene Inhibitory RNA Products For PFKFB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB4
- genomics-online: shRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PFKFB4 - Now 50% OFF >
- * PFKFB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PFKFB4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG207244
- MG215696
- MR207244
- MR207244L1
- MR207244L1V
- MR207244L2
- MR207244L2V
- MR207244L3
- MR207244L3V
- MR207244L4
- MR207244L4V
- MR215696
- MR215696L1
- MR215696L1V
- MR215696L2
- MR215696L2V
- MR215696L3
- MR215696L3V
- MR215696L4
- MR215696L4V
- RC201573
- RC201573L1
- RC201573L1V
- RC201573L2
- RC201573L2V
- RC201573L3
- RC201573L3V
- RC201573L4
- RC201573L4V
- RC501573
- RG201573
- RR214187
- RR214187L1
- RR214187L1V
- RR214187L2
- RR214187L2V
- RR214187L3
- RR214187L3V
- RR214187L4
- RR214187L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PFKFB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB4
Cell Line Products
-
Horizon Cell Lines for PFKFB4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PFKFB4 Gene
Localization for PFKFB4 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 3 |
| nucleus | 2 |
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PFKFB4 Gene
Pathways & Interactions for PFKFB4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fructose and mannose metabolism | ||
| 2 | Glucose metabolism |
.52
|
|
| 3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 4 | Akt Signaling |
.60
|
|
| 5 | AMPK Enzyme Complex Pathway | ||
Pathways by source for PFKFB4 Gene
1 BioSystems pathway for PFKFB4 Gene
4 Reactome pathways for PFKFB4 Gene
2 KEGG pathways for PFKFB4 Gene
2 Qiagen pathways for PFKFB4 Gene
Interacting Proteins for PFKFB4 Gene
Selected Interacting proteins:
Q16877-F264_HUMAN
ENSP00000232375
for PFKFB4 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for PFKFB4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006000 | fructose metabolic process | IEA | -- |
| GO:0006003 | fructose 2,6-bisphosphate metabolic process | IBA,IEA | 21873635 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for PFKFB4 Gene
Drugs & Compounds for PFKFB4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| fructose-6-phosphate | Experimental | Pharma | Target | 0 | ||
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Phosphoglyceric acid |
|
2553-59-5 |
|
|||
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| Beta-D-Fructose 6-phosphate |
|
|
||||
| D-Fructose 2,6-bisphosphate |
|
|
||||
| Fructose 6-phosphate |
|
643-13-0 |
|
Drug Products
- Atlas Antibodies PrEST Antigen PFKFB4 (APrEST88888) and PrEST Antigen PFKFB4 (APrEST91104)
Transcripts for PFKFB4 Gene
mRNA/cDNA for PFKFB4 Gene
- (6) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000232375 3499 bps (ENST00000232375.7)
- ENST00000416568 1575 bps (ENST00000416568.5)
- ENST00000417753 1744 bps (ENST00000417753.5)
- ENST00000445633 1733 bps (ENST00000445633.5)
- ENST00000383734 1491 bps (ENST00000383734.6)
Unigene Clusters for PFKFB4 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PFKFB4 - Now 50% OFF >
- * PFKFB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PFKFB4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for PFKFB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB4
- genomics-online: gRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PFKFB4
- Browse OriGene Inhibitory RNA Products For PFKFB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB4
- genomics-online: shRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for PFKFB4 - Now 50% OFF >
- * PFKFB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PFKFB4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG207244
- MG215696
- MR207244
- MR207244L1
- MR207244L1V
- MR207244L2
- MR207244L2V
- MR207244L3
- MR207244L3V
- MR207244L4
- MR207244L4V
- MR215696
- MR215696L1
- MR215696L1V
- MR215696L2
- MR215696L2V
- MR215696L3
- MR215696L3V
- MR215696L4
- MR215696L4V
- RC201573
- RC201573L1
- RC201573L1V
- RC201573L2
- RC201573L2V
- RC201573L3
- RC201573L3V
- RC201573L4
- RC201573L4V
- RC501573
- RG201573
- RR214187
- RR214187L1
- RR214187L1V
- RR214187L2
- RR214187L2V
- RR214187L3
- RR214187L3V
- RR214187L4
- RR214187L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PFKFB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB4
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for PFKFB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for PFKFB4 Gene
This gene is overexpressed in Whole Blood (x18.1).
This gene is overexpressed in Testis (37.3) and Ovary (23.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PFKFB4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PFKFB4 Gene:
PFKFB4SOURCE GeneReport for Unigene cluster for PFKFB4 Gene:
Hs.476217Evidence on tissue expression from TISSUES for PFKFB4 Gene
- Nervous system(2.7)
Primer Products
-
OriGene qPCR primer pairs for PFKFB4
-
OriGene qPCR primer pairs and template standards for PFKFB4
- genomics-online: primer clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PFKFB4 Gene
Orthologs for PFKFB4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PFKFB4 35 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PFKFB4 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PFKFB4 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PFKFB4 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pfkfb4 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pfkfb4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PFKFB4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PFKFB4 35 |
|
OneToOne | |
| LOC100859653 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | PFKFB4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pfkfb4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pfkfb4 35 34 |
|
OneToMany | |
| pfkfb4l 35 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Pfrx 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y110A7A.6b 36 |
|
|
|
| Y110A7A.6a 36 |
|
|
|||
| Y110A7A.6 35 |
|
ManyToMany | |||
| K02B2.1 35 36 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FBP26 35 |
|
OneToMany | |
| -- 37 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | F2KP 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0164100 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for PFKFB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PFKFB4 Gene
- ENSEMBL:
- Gene Tree for PFKFB4 (if available)
- TreeFam:
- Gene Tree for PFKFB4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PFKFB4: view image
Paralogs for PFKFB4 Gene
(4) SIMAP similar genes for PFKFB4 Gene using alignment to 11 proteins:
- F264_HUMAN
- B7Z5C3_HUMAN
- B7Z5L3_HUMAN
- C9JJ23_HUMAN
- C9JX77_HUMAN
- C9K0D8_HUMAN
- F8WC12_HUMAN
- F8WDY1_HUMAN
- Q5XLC2_HUMAN
- Q64EX5_HUMAN
- Q66S35_HUMAN
Variants for PFKFB4 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs377441767 | uncertain-significance, Dystrophic epidermolysis bullosa | 48,564,301(-) | G/A | upstream_transcript_variant | |
| rs74780677 | uncertain-significance, Dystrophic epidermolysis bullosa | 48,564,341(-) | A/G | upstream_transcript_variant | |
| rs886058627 | uncertain-significance, Dystrophic epidermolysis bullosa | 48,564,366(-) | T/A/G | upstream_transcript_variant | |
| VAR_036075 | A breast cancer sample | p.Asn181Lys | |||
| rs1000003120 | -- | 48,551,728(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
9.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PFKFB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PFKFB4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKFB4 Gene
Disorders for PFKFB4 Gene
Additional Disease Information for PFKFB4
No disorders were found for PFKFB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFKFB4 Gene
Publications for PFKFB4 Gene
- Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (PMID: 10095107) Manzano A … Bartrons R (Gene 1999) 2 3 4 23 58
- Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. (PMID: 15642344) Gómez M … Bartrons R (FEBS letters 2005) 3 4 23 58
- Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. (PMID: 15474002) Minchenko O … Esumi H (FEBS letters 2004) 3 4 23 58
- Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PMID: 8830046) Sakai A … Sakakibara R (Journal of biochemistry 1996) 2 3 4 58
- Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. (PMID: 25115398) Chesney J … Telang S (Oncotarget 2014) 2 3 58
ExternalLinks
Products for PFKFB4 Gene
- Custom Antibody ServicesOriGene Antibodies for PFKFB4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PFKFB4
- Search Origene for MassSpec and Protein Over-expression Lysates for PFKFB4
- Origene Custom Protein Services for PFKFB4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PFKFB4
- Browse OriGene Inhibitory RNA Products For PFKFB4
- OriGene qPCR primer pairs for PFKFB4
- OriGene qPCR primer pairs and template standards for PFKFB4
- OriGene CRISPR knockouts for PFKFB4
- MG207244
- MG215696
- MR207244
- MR207244L1
- MR207244L1V
- MR207244L2
- MR207244L2V
- MR207244L3
- MR207244L3V
- MR207244L4
- MR207244L4V
- MR215696
- MR215696L1
- MR215696L1V
- MR215696L2
- MR215696L2V
- MR215696L3
- MR215696L3V
- MR215696L4
- MR215696L4V
- RC201573
- RC201573L1
- RC201573L1V
- RC201573L2
- RC201573L2V
- RC201573L3
- RC201573L3V
- RC201573L4
- RC201573L4V
- RC501573
- RG201573
- RR214187
- RR214187L1
- RR214187L1V
- RR214187L2
- RR214187L2V
- RR214187L3
- RR214187L3V
- RR214187L4
- RR214187L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PFKFB4
- Sino Biological Human cDNA Clone for PFKFB4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PFKFB4
- Novus Biologicals proteins and lysates for PFKFB4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PFKFB4
- Abcam proteins for PFKFB4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PFKFB4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PFKFB4 (AFLGC-PFKFB4)
- Cyagen custom Knockout/knockin (KOKI) mouse models for PFKFB4
- antibodies-online: Search results for 34 available PFKFB4 Antibodies ranked by validation data
- Compare Top PFKFB4 Antibodies
- antibodies-online: Search results for available PFKFB4 related products ranked by validation data
- antibodies-online: Search results for 8 available PFKFB4 Proteins ranked by validation data
- Compare Top PFKFB4 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for PFKFB4
- Search Santa Cruz Biotechnology (SCBT) for PFKFB4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB4
- Horizon Cell Lines for PFKFB4
- genomics-online: cdna clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
- orf clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
- genomics-online: gRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
- genomics-online: primer clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
- genomics-online: shRNA clones - Search results for 104 available PFKFB4 gene related products
- Overview of 104 available PFKFB4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PFKFB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB4
- Biorbyt antibodies for PFKFB4
Sources for PFKFB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind