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The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
PFKFB4 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003824 | catalytic activity | IEA | -- |
GO:0003873 | 6-phosphofructo-2-kinase activity | IEA,NAS | 10095107 |
GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 32296183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Fructose and mannose metabolism | ||
2 | Glucose metabolism |
.52
|
|
3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
4 | Akt Signaling |
Akt Signaling
.60
|
|
5 | AMPK Enzyme Complex Pathway |
AMPK Enzyme Complex Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006000 | fructose metabolic process | IEA | -- |
GO:0006003 | fructose 2,6-bisphosphate metabolic process | IEA,IBA | 21873635 |
GO:0008152 | metabolic process | IEA | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0016311 | dephosphorylation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Phosphoglyceric acid |
|
2553-59-5 |
|
|||
ADP |
|
58-64-0 |
|
|||
Beta-D-Fructose 6-phosphate |
|
|
||||
D-Fructose 2,6-bisphosphate |
|
79082-92-1 |
|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PFKFB4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pfkfb4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pfkfb4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PFKFB4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PFKFB4 31 |
|
OneToOne | |
LOC100859653 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | PFKFB4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pfkfb4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pfkfb4 30 31 |
|
OneToMany | |
pfkfb4l 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pfrx 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | Y110A7A.6b 32 |
|
|
|
Y110A7A.6a 32 |
|
|
|||
Y110A7A.6 31 |
|
ManyToMany | |||
K02B2.1 31 32 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FBP26 31 |
|
OneToMany | |
-- 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | F2KP 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0164100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036075 | A breast cancer sample |
p.Asn181Lys |
No disorders were found for PFKFB4 Gene.