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The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount o... See more...
Aliases for PFKFB4 Gene
Aliases for PFKFB4 Gene
External Ids for PFKFB4 Gene
- HGNC: 8875
- Entrez Gene: 5210
- Ensembl: ENSG00000114268
- OMIM: 605320
- UniProtKB: Q16877
Previous GeneCards Identifiers for PFKFB4 Gene
- GC03M048349
- GC03M047841
- GC03M048516
- GC03M048530
- GC03M048555
Summaries for PFKFB4 Gene
-
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for PFKFB4 Gene
PFKFB4 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4) is a Protein Coding gene. Among its related pathways are Akt Signaling and Fructose and mannose metabolism. Gene Ontology (GO) annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB1.
UniProtKB/Swiss-Prot Summary for PFKFB4 Gene
-
Synthesis and degradation of fructose 2,6-bisphosphate.
Additional gene information for PFKFB4 Gene
- HGNC(8875)
- Entrez Gene(5210)
- Ensembl(ENSG00000114268)
- OMIM(605320)
- UniProtKB(Q16877)
- Open Targets Platform(ENSG00000114268)
- Monarch Initiative
- Search for PFKFB4 at DataMed
- Search for PFKFB4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PFKFB4 Gene
Genomics for PFKFB4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PFKFB4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PFKFB4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PFKFB4
- Top Transcription factor binding sites by QIAGEN in the PFKFB4 gene promoter:
-
- AML1a
Genomic Locations for PFKFB4 Gene
Genomic Locations for PFKFB4 Gene
- chr3:48,517,684-48,562,383
- (GRCh38/hg38)
- Size:
- 44,700 bases
- Orientation:
- Minus strand
- chr3:48,555,117-48,599,448
- (GRCh37/hg19)
- Size:
- 44,332 bases
- Orientation:
- Minus strand
Genomic View for PFKFB4 Gene
Genes around PFKFB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by HGNC
- 3p21.31 by Entrez Gene
- 3p21.31 by Ensembl
PFKFB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PFKFB4 Gene
Proteins for PFKFB4 Gene
-
Protein details for PFKFB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16877-F264_HUMAN
- Recommended name:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
- Protein Accession:
- Q16877
- Q5S3G5
- Q5XLC2
- Q64EX5
Protein attributes for PFKFB4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 54040 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for PFKFB4 Gene
Post-translational modifications for PFKFB4 Gene
Other Protein References for PFKFB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-PFKFB4 antibody and Anti-PFKFB4 antibody [N3C3]
- Creative Diagnostics Anti-PFKFB4 (aa 200-469) polyclonal antibody
- Creative Biolabs Mouse Anti-PFKFB4 Recombinant Antibody (1C8)
-
Custom Antibody ServicesOriGene Antibodies for PFKFB4
- Novus Biologicals Antibodies for PFKFB4
-
Abcam antibodies for PFKFB4
- Invitrogen Antibodies for PFKFB4 (AFLGC-PFKFB4)
-
Biorbyt antibodies for PFKFB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PFKFB4
- Sino Biological Antibodies for PFKFB4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PFKFB4
- Origene Custom Protein Services for PFKFB4
- antibodies-online: Show 10 available PFKFB4 Proteins ranked by validation data
- Compare Top PFKFB4 Proteins
-
Quality Products:
-
Signalway Proteins for PFKFB4
-
Abcam proteins for PFKFB4
No data available for DME Specific Peptides for PFKFB4 Gene
Domains & Families for PFKFB4 Gene
Gene Families for PFKFB4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PFKFB4 Gene
- InterPro:
- Blocks:
-
- Phosphoglycerate/bisphosphoglycerate mutase
- 6-phosphofructo-2-kinase
- ProtoNet:
Suggested Antigen Peptide Sequences for PFKFB4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58271, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (B7Z5C3_HUMAN)
- cDNA FLJ53771, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (B7Z5L3_HUMAN)
- 6PF-2-K/Fru-2,6-P2ase testis-type isozyme (F264_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16877UniProtKB/Swiss-Prot:
F264_HUMAN :- In the C-terminal section; belongs to the phosphoglycerate mutase family.
- Family:
-
- In the C-terminal section; belongs to the phosphoglycerate mutase family.
Function for PFKFB4 Gene
Molecular function for PFKFB4 Gene
- UniProtKB/Swiss-Prot Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+); Xref=Rhea:RHEA:15653, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579, ChEBI:CHEBI:456216; EC=2.7.1.105;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.
- GENATLAS Biochemistry:
- 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase bifunctional enzyme responsible for the synthesis and breakdown of fructose 2,6 biphosphate,key metabolite in the regulation of glycolysis,expressed in testis
Phenotypes From GWAS Catalog for PFKFB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0003873 | 6-phosphofructo-2-kinase activity | IEA,NAS | 10095107 |
| GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity | IBA | 21873635 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for PFKFB4 Gene
- MGI mutant phenotypes for PFKFB4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PFKFB4:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Strongly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased ionizing radiation sensitivity
- Decreased viability after Maraba virus infection
- Decreased viability
- Decreased shRNA abundance
- Increased homologous recombination repair frequency
- Downregulation of NFkappaB pathway
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation
Animal Models for PFKFB4 Gene
- MGI Knock Outs for PFKFB4:
-
- Pfkfb4 Pfkfb4<tm1b(KOMP)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for PFKFB4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PFKFB4 - Select products 50% OFF >
- * PFKFB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PFKFB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB4
miRNA for PFKFB4 Gene
- miRTarBase miRNAs that target PFKFB4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PFKFB4
- Browse OriGene Inhibitory RNA Products For PFKFB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB4
Clone Products
- Applied Biological Materials (abm): Clones for PFKFB4 - Select products 50% OFF >
- * PFKFB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207244
- MG215696
- MR207244
- MR207244L1
- MR207244L2
- MR207244L3
- MR207244L4
- MR215696
- MR215696L3
- MR215696L4
- RC201573
- RC201573L1
- RC201573L2
- RC201573L3
- RC201573L4
- RG201573
- RR214187
- RR214187L3
- RR214187L4
- MR207244L1V
- MR207244L2V
- MR207244L3V
- MR207244L4V
- MR215696L3V
- MR215696L4V
- RC201573L1V
- RC201573L2V
- RC201573L3V
- RC201573L4V
- RR214187L3V
- RR214187L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PFKFB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB4
Cell Line Products
-
Horizon Cell Lines for PFKFB4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PFKFB4 Gene
Localization for PFKFB4 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PFKFB4 Gene
Pathways & Interactions for PFKFB4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fructose and mannose metabolism | ||
| 2 | Glucose metabolism |
.52
|
|
| 3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 4 | Akt Signaling |
Akt Signaling
.60
|
|
| 5 | AMPK Enzyme Complex Pathway |
AMPK Enzyme Complex Pathway
-
|
|
Pathways by source for PFKFB4 Gene
1 BioSystems pathway for PFKFB4 Gene
4 Reactome pathways for PFKFB4 Gene
2 KEGG pathways for PFKFB4 Gene
2 Qiagen pathways for PFKFB4 Gene
- Akt Signaling
- AMPK Enzyme Complex Pathway
Interacting Proteins for PFKFB4 Gene
Selected Interacting proteins:
Q16877-F264_HUMAN
ENSP00000232375
for PFKFB4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PFKFB4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006000 | fructose metabolic process | IEA | -- |
| GO:0006003 | fructose 2,6-bisphosphate metabolic process | IEA,IBA | 21873635 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for PFKFB4 Gene
Drugs & Compounds for PFKFB4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| Fructose 6-phosphate | Experimental | Pharma | Target | 0 | ||
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Phosphoglyceric acid |
|
2553-59-5 |
|
|||
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
| Beta-D-Fructose 6-phosphate |
|
|
||||
| D-Fructose 2,6-bisphosphate |
|
|
||||
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for PFKFB4 Gene
mRNA/cDNA for PFKFB4 Gene
- 6 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000232375 3499 nts (view in UCSC)
- ENST00000383734 1491 nts (view in UCSC)
- ENST00000412035 567 nts (view in UCSC)
- ENST00000416568 1575 nts (view in UCSC)
- ENST00000417753 1744 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PFKFB4 - Select products 50% OFF >
- * PFKFB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PFKFB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PFKFB4
- Browse OriGene Inhibitory RNA Products For PFKFB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB4
Clone Products
- Applied Biological Materials (abm): Clones for PFKFB4 - Select products 50% OFF >
- * PFKFB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207244
- MG215696
- MR207244
- MR207244L1
- MR207244L2
- MR207244L3
- MR207244L4
- MR215696
- MR215696L3
- MR215696L4
- RC201573
- RC201573L1
- RC201573L2
- RC201573L3
- RC201573L4
- RG201573
- RR214187
- RR214187L3
- RR214187L4
- MR207244L1V
- MR207244L2V
- MR207244L3V
- MR207244L4V
- MR215696L3V
- MR215696L4V
- RC201573L1V
- RC201573L2V
- RC201573L3V
- RC201573L4V
- RR214187L3V
- RR214187L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PFKFB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB4
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for PFKFB4 Gene
- GeneLoc Exon Structure for
- PFKFB4
Expression for PFKFB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for PFKFB4 Gene
This gene is overexpressed in Whole Blood (x18.1).
This gene is overexpressed in Testis (37.3) and Ovary (23.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PFKFB4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PFKFB4
SOURCE GeneReport for Unigene cluster for PFKFB4 Gene:
Hs.476217Evidence on tissue expression from TISSUES for PFKFB4 Gene
- Nervous system(3.2)
- Blood(2.2)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for PFKFB4
-
OriGene qPCR primer pairs and template standards for PFKFB4
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PFKFB4 Gene
Orthologs for PFKFB4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PFKFB4 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PFKFB4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pfkfb4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pfkfb4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PFKFB4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PFKFB4 31 |
|
OneToOne | |
| LOC100859653 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | PFKFB4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pfkfb4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pfkfb4 30 31 |
|
OneToMany | |
| pfkfb4l 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pfrx 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y110A7A.6b 32 |
|
|
|
| Y110A7A.6a 32 |
|
|
|||
| Y110A7A.6 31 |
|
ManyToMany | |||
| K02B2.1 31 32 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FBP26 31 |
|
OneToMany | |
| -- 33 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | F2KP 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0164100 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for PFKFB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PFKFB4 Gene
- ENSEMBL:
- Gene Tree for PFKFB4 (if available)
- TreeFam:
- Gene Tree for PFKFB4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PFKFB4: view image
Paralogs for PFKFB4 Gene
(4) SIMAP similar genes for PFKFB4 Gene using alignment to 11 proteins:
- F264_HUMAN
- B7Z5C3_HUMAN
- B7Z5L3_HUMAN
- C9JJ23_HUMAN
- C9JX77_HUMAN
- C9K0D8_HUMAN
- F8WC12_HUMAN
- F8WDY1_HUMAN
- Q5XLC2_HUMAN
- Q64EX5_HUMAN
- Q66S35_HUMAN
Variants for PFKFB4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PFKFB4 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036075 | A breast cancer sample | p.Asn181Lys |
Residual Variation Intolerance Score:
9.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PFKFB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PFKFB4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKFB4 Gene
Disorders for PFKFB4 Gene
Additional Disease Information for PFKFB4
No disorders were found for PFKFB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFKFB4 Gene
Publications for PFKFB4 Gene
- Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (PMID: 10095107) Manzano A … Bartrons R (Gene 1999) 2 3 4 23
- Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. (PMID: 15642344) Gómez M … Bartrons R (FEBS letters 2005) 3 4 23
- Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. (PMID: 15474002) Minchenko O … Esumi H (FEBS letters 2004) 3 4 23
- Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PMID: 8830046) Sakai A … Sakakibara R (Journal of biochemistry 1996) 2 3 4
- Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. (PMID: 25115398) Chesney J … Telang S (Oncotarget 2014) 2 3
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