Aliases for PFKFB3 Gene
Aliases for PFKFB3 Gene
External Ids for PFKFB3 Gene
- HGNC: 8874
- Entrez Gene: 5209
- Ensembl: ENSG00000170525
- OMIM: 605319
- UniProtKB: Q16875
Previous GeneCards Identifiers for PFKFB3 Gene
- GC10P006189
- GC10P006395
- GC10P006248
- GC10P006226
- GC10P006284
- GC10P006186
Summaries for PFKFB3 Gene
-
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
GeneCards Summary for PFKFB3 Gene
PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a Protein Coding gene. Diseases associated with PFKFB3 include Colon Adenocarcinoma. Among its related pathways are Akt Signaling and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB2.
UniProtKB/Swiss-Prot for PFKFB3 Gene
-
Synthesis and degradation of fructose 2,6-bisphosphate.
Additional gene information for PFKFB3 Gene
- Monarch Initiative
- Search for PFKFB3 at DataMed
- Search for PFKFB3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFKFB3 Gene
Genomics for PFKFB3 Gene
GeneHancer (GH) Regulatory Elements for PFKFB3 Gene
Promoters and enhancers for PFKFB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PFKFB3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PFKFB3 gene promoter:
-
- c-Ets-1
- POU3F2 (N-Oct-5b)
- POU3F2 (N-Oct-5a)
- POU3F2
- deltaCREB
- CREB
- Arnt
- USF-1
- USF-1:USF-2
- USF1
Regulatory Element Products
Genomic Locations for PFKFB3 Gene
Genomic Locations for PFKFB3 Gene
- chr10:6,144,880-6,254,644
- (GRCh38/hg38)
- Size:
- 109,765 bases
- Orientation:
- Plus strand
- chr10:6,186,843-6,277,508
- (GRCh37/hg19)
- Size:
- 90,666 bases
- Orientation:
- Plus strand
Genomic View for PFKFB3 Gene
Genes around PFKFB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.1 by Entrez Gene
- 10p15.1 by HGNC
- 10p15.1 by Ensembl
PFKFB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PFKFB3 Gene
Proteins for PFKFB3 Gene
-
Protein details for PFKFB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16875-F263_HUMAN
- Recommended name:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- Protein Accession:
- Q16875
- B7Z955
- O43622
- O75902
- Q5VX15
- Q5VX18
- Q5VX19
Protein attributes for PFKFB3 Gene
- Size:
- 520 amino acids
- Molecular mass:
- 59609 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for PFKFB3 Gene
Protein Expression for PFKFB3 Gene
Post-translational modifications for PFKFB3 Gene
- Phosphorylation by AMPK stimulates activity.
- Ubiquitination at Lys302
- Modification sites at PhosphoSitePlus
Other Protein References for PFKFB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PFKFB3
- Novus Biologicals Antibodies for PFKFB3
-
Abcam antibodies for PFKFB3
- Invitrogen Antibodies for PFKFB3 (AFLGC-PFKFB3)
- antibodies-online: Search results for 87 available PFKFB3 Antibodies ranked by validation data
- Compare Top PFKFB3 Antibodies
-
Recommended
- GeneTex PFKFB3 Antibody for PFKFB3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PFKFB3
Protein Products
- R&D Systems Proteins and Enzymes for PFKFB3
-
OriGene Purified Proteins for PFKFB3
- Search Origene for MassSpec and Protein Over-expression Lysates for PFKFB3
- Origene Custom Protein Services for PFKFB3
- Sino Biological Recombinant Proteins for PFKFB3
- Sino Biological Cell Lysates for PFKFB3
- Search GeneTex for Proteins for PFKFB3
-
Abcam proteins for PFKFB3
Assay Products
- antibodies-online: Search results for 1 available PFKFB3 Elisa Kits ranked by validation data
- Compare Top PFKFB3 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for PFKFB3 Gene
Domains & Families for PFKFB3 Gene
Gene Families for PFKFB3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PFKFB3 Gene
Suggested Antigen Peptide Sequences for PFKFB3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54731, highly similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (B7Z955_HUMAN)
- iPFK-2 (F263_HUMAN)
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphata se 3 (Q5VX17_HUMAN)
- cDNA FLJ75111, highly similar to Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3), mRNA (Q5VX18_HUMAN)
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphata se 3 (Q9BQU1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16875UniProtKB/Swiss-Prot:
F263_HUMAN :- In the C-terminal section; belongs to the phosphoglycerate mutase family.
- Family:
-
- In the C-terminal section; belongs to the phosphoglycerate mutase family.
Function for PFKFB3 Gene
Molecular function for PFKFB3 Gene
- UniProtKB/Swiss-Prot Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
- GENATLAS Biochemistry:
- fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,?,expressed in kidney
Phenotypes From GWAS Catalog for PFKFB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0003873 | 6-phosphofructo-2-kinase activity | NAS,IEA | 8830046 |
| GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for PFKFB3 Gene
- MGI mutant phenotypes for PFKFB3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PFKFB3:
-
- Dynamic nuclei (hole, folded or small irregular)
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Decreased 12E8 tau but not total tau protein expression and decreased ratio of 12E8/total tau protein expression
- shRNA abundance <= 50%
- Increased simian virus 40 (SV40) infection
Animal Models for PFKFB3 Gene
- MGI Knock Outs for PFKFB3:
-
- Pfkfb3 Pfkfb3<tm1Jche>
Animal Model Products
-
Taconic Biosciences Mouse Models for PFKFB3
- Cyagen custom Knockout/knockin (KOKI) mouse models for PFKFB3
-
CRISPR Products
-
OriGene CRISPR knockouts for PFKFB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB3
- genomics-online: gRNA clones - Search results for 175 available PFKFB3 gene related products
- Overview of 175 available PFKFB3 gene related products
- Applied Biological Materials CRISPR for PFKFB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB3
- GenScript: Design CRISPR guide RNA sequences for PFKFB3
miRNA for PFKFB3 Gene
- miRTarBase miRNAs that target PFKFB3
-
- hsa-mir-26b-5p (MIRT028775)
- hsa-mir-330-3p (MIRT043840)
- hsa-mir-6779-5p (MIRT454747)
- hsa-mir-6780a-5p (MIRT454748)
- hsa-mir-3689c (MIRT454749)
- hsa-mir-3689b-3p (MIRT454750)
- hsa-mir-3689a-3p (MIRT454751)
- hsa-mir-30b-3p (MIRT454752)
- hsa-mir-1273h-5p (MIRT454753)
- hsa-mir-6778-5p (MIRT454754)
- hsa-mir-1233-5p (MIRT454755)
- hsa-mir-6799-5p (MIRT454756)
- hsa-mir-7106-5p (MIRT454757)
- hsa-mir-6775-3p (MIRT454758)
- hsa-mir-1291 (MIRT454759)
- hsa-mir-765 (MIRT454760)
- hsa-mir-423-5p (MIRT454761)
- hsa-mir-3184-5p (MIRT454762)
- hsa-mir-6856-5p (MIRT454763)
- hsa-mir-6758-5p (MIRT454764)
- hsa-mir-3185 (MIRT527973)
- hsa-mir-6892-3p (MIRT527974)
- hsa-mir-6840-5p (MIRT527975)
- hsa-mir-6865-3p (MIRT527976)
- hsa-mir-149-3p (MIRT737769)
- hsa-mir-185-5p (MIRT738253)
- hsa-mir-3150b-3p (MIRT740322)
- hsa-mir-4306 (MIRT743909)
- hsa-mir-4644 (MIRT746381)
- hsa-mir-4728-5p (MIRT747865)
- hsa-mir-4784 (MIRT748839)
- hsa-mir-6785-5p (MIRT755860)
- hsa-mir-6883-5p (MIRT758445)
- hsa-mir-1271-5p (MIRT790072)
- hsa-mir-182-5p (MIRT790132)
- hsa-mir-183-5p (MIRT790135)
- hsa-mir-3609 (MIRT790310)
- hsa-mir-548ah-5p (MIRT790736)
- hsa-mir-548az-5p (MIRT790745)
- hsa-mir-548t-5p (MIRT790752)
- hsa-mir-6759-3p (MIRT790931)
- hsa-mir-6782-3p (MIRT790957)
- hsa-mir-96-5p (MIRT791175)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PFKFB3
- Browse OriGene Inhibitory RNA Products For PFKFB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB3
- genomics-online: shRNA clones - Search results for 175 available PFKFB3 gene related products
- Overview of 175 available PFKFB3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PFKFB3
- Addgene plasmids for PFKFB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB3
- Applied Biological Materials Clones for PFKFB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PFKFB3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PFKFB3 Gene
Localization for PFKFB3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PFKFB3 Gene
Pathways & Interactions for PFKFB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Fructose and mannose metabolism | ||
| 3 | Glucose metabolism |
.52
|
|
| 4 | HIF-1 signaling pathway | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for PFKFB3 Gene
1 Sino Biological pathway for PFKFB3 Gene
3 BioSystems pathways for PFKFB3 Gene
4 Reactome pathways for PFKFB3 Gene
3 KEGG pathways for PFKFB3 Gene
2 Qiagen pathways for PFKFB3 Gene
1 Cell Signaling Technology pathway for PFKFB3 Gene
Interacting Proteins for PFKFB3 Gene
GPS-Prot Interaction Network for PFKFB3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006000 | fructose metabolic process | IEA | -- |
| GO:0006003 | fructose 2,6-bisphosphate metabolic process | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for PFKFB3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 | |||
| 2-Phosphoglyceric acid |
|
2553-59-5 |
|
|||
| Beta-D-Fructose 6-phosphate |
|
|
||||
| D-Fructose 2,6-bisphosphate |
|
|
||||
| Fructose 6-phosphate |
|
643-13-0 |
|
Drug Products
Transcripts for PFKFB3 Gene
mRNA/cDNA for PFKFB3 Gene
- (14) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (213) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000379789 4157 bps (uc001ijd.4)
- ENST00000536985 2094 bps (uc010qaw.3)
- ENST00000639949 587 bps
- ENST00000317350 1999 bps (uc057rmt.1)
- ENST00000461744 2098 bps (uc057rmu.1)
Unigene Clusters for PFKFB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PFKFB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PFKFB3
- genomics-online: gRNA clones - Search results for 175 available PFKFB3 gene related products
- Overview of 175 available PFKFB3 gene related products
- Applied Biological Materials CRISPR for PFKFB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PFKFB3
- GenScript: Design CRISPR guide RNA sequences for PFKFB3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PFKFB3
- Browse OriGene Inhibitory RNA Products For PFKFB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PFKFB3
- genomics-online: shRNA clones - Search results for 175 available PFKFB3 gene related products
- Overview of 175 available PFKFB3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PFKFB3
- Addgene plasmids for PFKFB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PFKFB3
- Applied Biological Materials Clones for PFKFB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | · | 19d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | - | - | |||||||||||||
| SP3: | - | - | - | ||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | - | ||||||||||||||||
| SP6: | - | ||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: |
Expression for PFKFB3 Gene
mRNA differential expression in normal tissues according to GTEx for PFKFB3 Gene
This gene is overexpressed in Muscle - Skeletal (x10.1), Whole Blood (x5.7), and Adipose - Subcutaneous (x4.4).
This gene is overexpressed in Plasma (18.1), Heart (13.6), Spleen (10.6), and Peripheral blood mononuclear cells (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PFKFB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PFKFB3 Gene:
PFKFB3SOURCE GeneReport for Unigene cluster for PFKFB3 Gene:
Hs.195471mRNA Expression by UniProt/SwissProt for PFKFB3 Gene:
Q16875-F263_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for PFKFB3 Gene
- Nervous system(5)
- Muscle(4.6)
- Liver(2.4)
- Heart(2.3)
- Kidney(2.3)
- Intestine(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for PFKFB3
-
OriGene qPCR primer pairs and template standards for PFKFB3
- genomics-online: primer clones - Search results for 175 available PFKFB3 gene related products
- Overview of 175 available PFKFB3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PFKFB3 Gene
Orthologs for PFKFB3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PFKFB3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PFKFB3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PFKFB3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Pfkfb3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pfkfb3 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PFKFB3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PFKFB3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PFKFB3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PFKFB3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pfkfb3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pfkfb3 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Pfrx 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y110A7A.6 34 33 |
|
ManyToMany | |
| Y110A7A.6b 35 |
|
|
|||
| Y110A7A.6a 35 |
|
|
|||
| K02B2.1 34 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FBP26 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PFKFB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PFKFB3 Gene
- ENSEMBL:
- Gene Tree for PFKFB3 (if available)
- TreeFam:
- Gene Tree for PFKFB3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PFKFB3: view image
Paralogs for PFKFB3 Gene
(138) SIMAP similar genes for PFKFB3 Gene using alignment to 12 proteins:
- F263_HUMAN
- B7Z955_HUMAN
- F2Z2I2_HUMAN
- F5H5L1_HUMAN
- H0Y483_HUMAN
- H0YDV0_HUMAN
- Q5VX20_HUMAN
- Q5W015_HUMAN
- Q9BQU1_HUMAN
- Q9BQU2_HUMAN
- Q9BQU3_HUMAN
- Q9H178_HUMAN
- PFK2
- HINFP
- VPS33A
- SPG7
- PARK2
- PACRG
- ZNF620
- ZNF114
- IRF2
- ARL6IP5
- ADCK1
- TUBA1C
- NKIRAS2
- MRPL45
- FTSJ2
- ZNF554
- PTPLAD1
- PFKFB4
- MFSD12
- CDK10
- AARSD1
- PFKFB2
- UBXN4
- TAF2
- PUS1
- KIAA1651
- RRM2B
- ZNF799
- RQCD1
- PPP2R5C
- C1orf143
- ZNF85
- ZNF66
- ZMAT1
- TMEM78
- SUN3
- PPIL6
- IRF5
- FAM3A
- DUSP3
- C12orf76
- DKFZp781D2217
- RBP7
- EIF3G
- CLTA
- AAMDC
- RPS13
- RHBG
- PPP5D1
- NUP93
- NDC80
- DYNC1LI1
- AAR2
- SLC35E3
- FANCA
- PFKFB1
- ZNF28
- SLC16A3
- PGS1
- ATF1
- DYNC2LI1
- BIRC3
- ZNF180
- ZNF559
- TNNT1
- SEC14L3
- PTPN22
- LINC00999
- ERMN
- C4BPB
- C14orf105
- BEAN1
- UTY
- TMX3
- CALCOCO2
- ASCC1
- NLN
- ZNF415
- TFR2
- NEK4
- GCDH
- FRG1
- DOCK8
- C3orf33
- C11orf80
- AVGR8
- ARIH1
- NELFA
- ZNF429
- IDNK
- GEMIN6
- EEF1E1
- TP63
- NR5A2
- SUV420H1
- NLRC5
- COQ5
- TM2D1
- pp12301
- RARS
- SLC38A6
- SH3BP1
- RPGRIP1L
- PDILT
- MUC20
- DPP9
- CEP95
- C21orf37
- ARGFX
- IK
- SEPSECS
- LSM12
- HEXDC
- C13orf45
- NAE1
- LDLRAD3
- CCDC122
- GALK2
- NDUFS3
- CNN2
- CCNJL
- ZNF257
- TBCB
- FBLN5
- MST132
- GNB2L1
- CATSPERD
- EIF3K
- C17orf86
- ADRA1A
- SMYD4
- MMADHC
- ABI2
- FCER1G
- TCTEX1D2
- NOSTRIN
- FLJ00047
- DUSP11
Variants for PFKFB3 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021838 | -- | 6,207,547(+) | C/T | intron_variant | |
| rs1000030158 | -- | 6,190,676(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000077629 | -- | 6,168,822(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000083349 | -- | 6,239,548(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000113920 | -- | 6,158,141(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv124n67 | CNV | loss | 20364138 |
| dgv1e49 | CNV | loss | 18971310 |
| dgv66n27 | CNV | gain | 19166990 |
| dgv88e201 | CNV | deletion | 23290073 |
| dgv949n54 | CNV | gain | 21841781 |
| esv1353057 | CNV | deletion | 17803354 |
| esv2626974 | CNV | deletion | 19546169 |
| esv2731929 | CNV | deletion | 23290073 |
| esv3306994 | CNV | mobile element insertion | 20981092 |
| esv3401171 | CNV | insertion | 20981092 |
| esv3438991 | CNV | insertion | 20981092 |
| esv3545839 | CNV | deletion | 23714750 |
| esv3622241 | CNV | gain | 21293372 |
| esv3622242 | CNV | gain | 21293372 |
| esv3622243 | CNV | loss | 21293372 |
| esv994076 | CNV | deletion | 20482838 |
| nsv1072583 | CNV | deletion | 25765185 |
| nsv1136109 | CNV | deletion | 24896259 |
| nsv24567 | CNV | deletion | 16902084 |
| nsv437094 | CNV | loss | 16327808 |
| nsv437656 | CNV | loss | 16327808 |
| nsv512142 | CNV | loss | 21212237 |
| nsv521145 | CNV | loss | 19592680 |
| nsv525622 | CNV | gain | 19592680 |
| nsv5665 | CNV | insertion | 18451855 |
| nsv7198 | OTHER | inversion | 18451855 |
| nsv825235 | CNV | loss | 20364138 |
| nsv958544 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.43;
28.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PFKFB3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PFKFB3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKFB3 Gene
Disorders for PFKFB3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colon adenocarcinoma |
|
Search PFKFB3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PFKFB3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PFKFB3 Gene
Publications for PFKFB3 Gene
- Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3). (PMID: 10072580) Manzano A … Bartrons R (Cytogenetics and cell genetics 1998) 2 3 4 22 58
- The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15. (PMID: 9146922) Nicholl J … Watts CK (Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1997) 2 3 4 22 58
- Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function. (PMID: 22275052) Cavalier MC … Lee YH (Proteins 2012) 2 3 4 58
- A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. (PMID: 17499765) Kim SG … Lee YH (Journal of molecular biology 2007) 3 4 22 58
- Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. (PMID: 16316985) Kim SG … Lee YH (The Journal of biological chemistry 2006) 3 4 22 58
Products for PFKFB3 Gene
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- antibodies-online: Search results for 87 available PFKFB3 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 175 available PFKFB3 gene related products
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Sources for PFKFB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt