Aliases for PFKFB2 Gene
External Ids for PFKFB2 Gene
Previous GeneCards Identifiers for PFKFB2 Gene
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PFKFB2 Gene
PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) is a Protein Coding gene. Among its related pathways are AKT Siganaling Pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and 6-phosphofructo-2-kinase activity. An important paralog of this gene is PFKFB3.
UniProtKB/Swiss-Prot Summary for PFKFB2 Gene
Synthesis and degradation of fructose 2,6-bisphosphate.