Aliases for PFDN6 Gene
External Ids for PFDN6 Gene
Previous HGNC Symbols for PFDN6 Gene
Previous GeneCards Identifiers for PFDN6 Gene
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
GeneCards Summary for PFDN6 Gene
PFDN6 (Prefoldin Subunit 6) is a Protein Coding gene. Diseases associated with PFDN6 include Corneal Deposit and Corneal Dystrophy. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding.
UniProtKB/Swiss-Prot Summary for PFDN6 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.