Aliases for PFDN4 Gene
External Ids for PFDN4 Gene
Previous GeneCards Identifiers for PFDN4 Gene
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
GeneCards Summary for PFDN4 Gene
PFDN4 (Prefoldin Subunit 4) is a Protein Coding gene. Diseases associated with PFDN4 include Arthrogryposis, Distal, Type 2A and Arthrogryposis, Distal, Type 5. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding.
UniProtKB/Swiss-Prot Summary for PFDN4 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.