External Ids for PFDN1 Gene
Previous GeneCards Identifiers for PFDN1 Gene
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
GeneCards Summary for PFDN1 Gene
PFDN1 (Prefoldin Subunit 1) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein binding involved in protein folding.
UniProtKB/Swiss-Prot Summary for PFDN1 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.