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Aliases for PF4V1 Gene

Aliases for PF4V1 Gene

  • Platelet Factor 4 Variant 1 2 3 5
  • Platelet Factor 4 Variant 3 4
  • CXCL4L1 3 4
  • CXCL4V1 3 4
  • PF4var1 3 4
  • SCYB4V1 3 4
  • PF4alt 3 4
  • Platelet Factor 4, Variant 1 (PF4-Like) 3
  • C-X-C Motif Chemokine 4 Variant 4
  • C-X-C Motif Chemokine 4 3
  • PF4-ALT 3
  • PF4A 3

External Ids for PF4V1 Gene

Previous GeneCards Identifiers for PF4V1 Gene

  • GC04P074708
  • GC04P074958
  • GC04P075119
  • GC04P075185
  • GC04P075084
  • GC04P074718
  • GC04P070530

Summaries for PF4V1 Gene

Entrez Gene Summary for PF4V1 Gene

  • The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for PF4V1 Gene

PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for PF4V1 Gene

  • Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

Additional gene information for PF4V1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PF4V1 Gene

Genomics for PF4V1 Gene

GeneHancer (GH) Regulatory Elements for PF4V1 Gene

Promoters and enhancers for PF4V1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073853 Promoter/Enhancer 1.2 EPDnew Ensembl 578 +0.4 412 0.8 ZIC2 SP7 ZNF341 CTCF ZBTB48 ZNF10 ZBTB26 ZBTB17 ZNF610 WT1 PF4V1 CXCL1
GH04J073739 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 14.6 -112.5 -112529 2.7 GTF2F1 MLLT1 TEAD4 SMARCA4 MAFK TRIM24 MTA1 IKZF1 PRDM10 NFE2L2 CXCL8 PF4V1 GC04P073743
GH04J073867 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.3 +16.3 16290 3.2 L3MBTL2 SMARCA4 RAD21 IKZF1 GLIS2 ZIC2 REST PRDM10 PKNOX1 ZNF341 CXCL1 PF4V1 PF4 HNRNPA1P55
GH04J073702 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -148.5 -148491 3.8 CEBPB ZBTB33 DACH1 SP1 ZKSCAN8 ZFX CBFA2T2 L3MBTL2 TEAD4 SMARCA4 CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 ENSG00000228277 CXCL5 MTHFD2L CXCL1
GH04J073730 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -119.8 -119779 5.2 SPI1 SP1 ZNF687 ZNF24 TEAD4 SMARCA4 TRIM24 JUND CREM BACH1 CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PF4V1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PF4V1 gene promoter:
  • AML1a
  • ATF-2
  • Evi-1
  • MyoD
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for PF4V1 Gene

Genomic Locations for PF4V1 Gene
1,293 bases
Plus strand
1,293 bases
Plus strand

Genomic View for PF4V1 Gene

Genes around PF4V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PF4V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PF4V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PF4V1 Gene

Proteins for PF4V1 Gene

  • Protein details for PF4V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Platelet factor 4 variant
    Protein Accession:
    Secondary Accessions:
    • A1L4S0

    Protein attributes for PF4V1 Gene

    104 amino acids
    Molecular mass:
    11553 Da
    Quaternary structure:
    • Homotetramer.
    • Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

    Three dimensional structures from OCA and Proteopedia for PF4V1 Gene

neXtProt entry for PF4V1 Gene

Post-translational modifications for PF4V1 Gene

  • The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PF4V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PF4V1 Gene

Domains & Families for PF4V1 Gene

Gene Families for PF4V1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PF4V1 Gene

GenScript: Design optimal peptide antigens:
  • PF4var1 (PF4V_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with PF4V1: view

Function for PF4V1 Gene

Molecular function for PF4V1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).
GENATLAS Biochemistry:
platelet factor 4,variant 1 (see IMC2@)

Phenotypes From GWAS Catalog for PF4V1 Gene

Gene Ontology (GO) - Molecular Function for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity IBA 21873635
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with PF4V1: view
genes like me logo Genes that share phenotypes with PF4V1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PF4V1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PF4V1 Gene

Localization for PF4V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PF4V1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PF4V1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with PF4V1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PF4V1 Gene

Pathways & Interactions for PF4V1 Gene

genes like me logo Genes that share pathways with PF4V1: view

Gene Ontology (GO) - Biological Process for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IBA 21873635
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with PF4V1: view

No data available for SIGNOR curated interactions for PF4V1 Gene

Drugs & Compounds for PF4V1 Gene

No Compound Related Data Available

Transcripts for PF4V1 Gene

mRNA/cDNA for PF4V1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PF4V1 Gene

Platelet factor 4 variant 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PF4V1

Alternative Splicing Database (ASD) splice patterns (SP) for PF4V1 Gene

No ASD Table

Relevant External Links for PF4V1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PF4V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PF4V1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PF4V1 Gene

This gene is overexpressed in Whole Blood (x28.3) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for PF4V1 Gene

This gene is overexpressed in Monocytes (29.3), Serum (16.1), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PF4V1 Gene

Protein tissue co-expression partners for PF4V1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PF4V1 Gene:


SOURCE GeneReport for Unigene cluster for PF4V1 Gene:


Evidence on tissue expression from TISSUES for PF4V1 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with PF4V1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PF4V1 Gene

Orthologs for PF4V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PF4V1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PF4V1 35 34
  • 96.79 (n)
(Mus musculus)
Mammalia Pf4 35
  • 65 (a)
(Bos Taurus)
Mammalia PF4 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 41 (a)
-- 35
  • 37 (a)
-- 35
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 35 (a)
(Gallus gallus)
Aves -- 35
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
Species where no ortholog for PF4V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PF4V1 Gene

Gene Tree for PF4V1 (if available)
Gene Tree for PF4V1 (if available)
Evolutionary constrained regions (ECRs) for PF4V1: view image

Paralogs for PF4V1 Gene

Paralogs for PF4V1 Gene

(9) SIMAP similar genes for PF4V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PF4V1: view

Variants for PF4V1 Gene

Sequence variations from dbSNP and Humsavar for PF4V1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000494433 -- 73,854,948(+) A/G downstream_transcript_variant
rs1000633386 -- 73,854,704(+) C/T downstream_transcript_variant
rs1003176557 -- 73,852,422(+) T/C upstream_transcript_variant
rs1004772460 -- 73,854,296(+) T/C 3_prime_UTR_variant
rs1005140536 -- 73,851,858(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PF4V1 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958
nsv4389 CNV insertion 18451855

Variation tolerance for PF4V1 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PF4V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PF4V1 Gene

Disorders for PF4V1 Gene

Additional Disease Information for PF4V1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PF4V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PF4V1 Gene

Publications for PF4V1 Gene

  1. Identification and characterization of PF4varl, a human gene variant of platelet factor 4. (PMID: 2725510) Green CJ … Johnson PH (Molecular and cellular biology 1989) 2 3 4 58
  2. Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1. (PMID: 23536183) Kuo JH … Sue SC (The Journal of biological chemistry 2013) 3 4 58
  3. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian AD … CF Gene Modifier Study Group (Genes and immunity 2008) 3 45 58
  4. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PMID: 15459074) Struyf S … Strieter RM (Circulation research 2004) 3 4 58
  5. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PMID: 1695112) Eisman R … Poncz M (Blood 1990) 3 4 58

Products for PF4V1 Gene

Sources for PF4V1 Gene

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