Aliases for PF4V1 Gene
External Ids for PF4V1 Gene
Previous GeneCards Identifiers for PF4V1 Gene
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
GeneCards Summary for PF4V1 Gene
PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Diseases associated with PF4V1 include Herpetic Whitlow. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is PF4.
UniProtKB/Swiss-Prot Summary for PF4V1 Gene
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).