Aliases for PF4 Gene
External Ids for PF4 Gene
Previous GeneCards Identifiers for PF4 Gene
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]
GeneCards Summary for PF4 Gene
PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include Intermediate Coronary Syndrome and Erythromelalgia. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR3 chemokine receptor binding. An important paralog of this gene is PF4V1.
UniProtKB/Swiss-Prot Summary for PF4 Gene
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.