The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] See more...

Aliases for PEX11G Gene

Aliases for PEX11G Gene

  • Peroxisomal Biogenesis Factor 11 Gamma 2 3 5
  • Peroxisomal Biogenesis Factor 11C 3 4
  • Peroxisomal Membrane Protein 11C 3 4
  • Protein PEX11 Homolog Gamma 3 4
  • Peroxin-11C 3 4
  • PEX11-Gamma 3 4
  • Peroxisomal Biogenesis Factor 11G 3
  • Peroxin Pex11p Gamma 3
  • Pex11pgamma 3
  • PEX11C 4

External Ids for PEX11G Gene

Previous GeneCards Identifiers for PEX11G Gene

  • GC19M007436
  • GC19M007447
  • GC19M007541
  • GC19M007213

Summaries for PEX11G Gene

Entrez Gene Summary for PEX11G Gene

  • The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for PEX11G Gene

PEX11G (Peroxisomal Biogenesis Factor 11 Gamma) is a Protein Coding gene. Diseases associated with PEX11G include Peroxisome Biogenesis Disorder 1B and Zellweger Syndrome. Among its related pathways are Peroxisome.

UniProtKB/Swiss-Prot Summary for PEX11G Gene

  • Promotes membrane protrusion and elongation on the peroxisomal surface.

Additional gene information for PEX11G Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PEX11G Gene

Genomics for PEX11G Gene

GeneHancer (GH) Regulatory Elements for PEX11G Gene

Promoters and enhancers for PEX11G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007487 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 524.2 +8.4 8375 2.3 EP300 NRF1 MYC USF1 NCOR1 PHF8 JUND POLR2A TCF7 ZBTB26 PEX11G piR-43939-015 TEX45 L13712-013
GH19J007498 Promoter 0.6 EPDnew 500.7 +0.0 15 0.1 CTCF NRF1 RAD21 ZNF143 PEX11G RF00017-2785 piR-57460-337 TEX45 L13712-013
GH19J007497 Promoter 0.6 EPDnew 500.7 -0.1 -55 0.1 CTCF NRF1 RAD21 ZNF143 PEX11G RF00017-2785 TEX45 piR-57460-337 L13712-013
GH19J007499 Enhancer 0.6 FANTOM5 Ensembl 500.7 -1.7 -1716 2 ZFP36 ZNF121 ZSCAN4 PEX11G piR-57460-337 TEX45 PCP2 PNPLA6 EVI5L ENSG00000267952 L13712-013
GH19J007482 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 49.3 +14.0 13954 2 NRF1 ZNF263 CTBP1 POLR2A KLF9 NFIC CEBPB SMARCB1 IRF1 EGR1 PEX11G ARHGEF18 MCOLN1 EVI5L STXBP2 PNPLA6 CD209 RF00017-2784 piR-43939-015 L13712-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PEX11G on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PEX11G

Top Transcription factor binding sites by QIAGEN in the PEX11G gene promoter:
  • Arnt
  • ATF-2
  • ATF6
  • c-Jun
  • E4BP4
  • NRSF form 1
  • NRSF form 2
  • Zic3

Genomic Locations for PEX11G Gene

Genomic Locations for PEX11G Gene
chr19:7,476,870-7,497,485
(GRCh38/hg38)
Size:
20,616 bases
Orientation:
Minus strand
chr19:7,541,761-7,562,335
(GRCh37/hg19)
Size:
20,575 bases
Orientation:
Minus strand

Genomic View for PEX11G Gene

Genes around PEX11G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEX11G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEX11G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEX11G Gene

Proteins for PEX11G Gene

  • Protein details for PEX11G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HA9-PX11C_HUMAN
    Recommended name:
    Peroxisomal membrane protein 11C
    Protein Accession:
    Q96HA9
    Secondary Accessions:
    • Q8NDM0

    Protein attributes for PEX11G Gene

    Size:
    241 amino acids
    Molecular mass:
    26636 Da
    Quaternary structure:
    • Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts with FIS1.

    Alternative splice isoforms for PEX11G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEX11G Gene

Post-translational modifications for PEX11G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PEX11G Gene

Domains & Families for PEX11G Gene

Gene Families for PEX11G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PEX11G Gene

Blocks:
  • Peroxisomal biogenesis factor 11
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PEX11G Gene

GenScript: Design optimal peptide antigens:
  • Protein PEX11 homolog gamma (PX11C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HA9

UniProtKB/Swiss-Prot:

PX11C_HUMAN :
  • Belongs to the peroxin-11 family.
Family:
  • Belongs to the peroxin-11 family.
genes like me logo Genes that share domains with PEX11G: view

Function for PEX11G Gene

Molecular function for PEX11G Gene

UniProtKB/Swiss-Prot Function:
Promotes membrane protrusion and elongation on the peroxisomal surface.

Phenotypes From GWAS Catalog for PEX11G Gene

Gene Ontology (GO) - Molecular Function for PEX11G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20826455
genes like me logo Genes that share ontologies with PEX11G: view
genes like me logo Genes that share phenotypes with PEX11G: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PEX11G Gene

Localization for PEX11G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEX11G Gene

Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEX11G gene
Compartment Confidence
peroxisome 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
plasma membrane 0
cytoskeleton 0
nucleus 0
lysosome 0

Gene Ontology (GO) - Cellular Components for PEX11G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA,IEA 20826455
GO:0005778 peroxisomal membrane IEA --
GO:0005779 integral component of peroxisomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PEX11G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PEX11G Gene

Pathways & Interactions for PEX11G Gene

PathCards logo

SuperPathways for PEX11G Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with PEX11G: view

Pathways by source for PEX11G Gene

1 KEGG pathway for PEX11G Gene

Gene Ontology (GO) - Biological Process for PEX11G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016559 peroxisome fission IDA,IEA 20826455
GO:0044375 regulation of peroxisome size IDA 20826455
genes like me logo Genes that share ontologies with PEX11G: view

No data available for SIGNOR curated interactions for PEX11G Gene

Drugs & Compounds for PEX11G Gene

No Compound Related Data Available

Transcripts for PEX11G Gene

mRNA/cDNA for PEX11G Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PEX11G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3:

Relevant External Links for PEX11G Gene

GeneLoc Exon Structure for
PEX11G

Expression for PEX11G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PEX11G Gene

mRNA differential expression in normal tissues according to GTEx for PEX11G Gene

This gene is overexpressed in Testis (x6.3) and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for PEX11G Gene

This gene is overexpressed in Ovary (17.1), Testis (16.5), Gallbladder (14.3), and Liver (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PEX11G Gene



Protein tissue co-expression partners for PEX11G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PEX11G

SOURCE GeneReport for Unigene cluster for PEX11G Gene:

Hs.515100

Evidence on tissue expression from TISSUES for PEX11G Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with PEX11G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEX11G Gene

Orthologs for PEX11G Gene

This gene was present in the common ancestor of animals.

Orthologs for PEX11G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEX11G 31 30
  • 98.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PEX11G 31 30
  • 84.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PEX11G 31 30
  • 83.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pex11g 30
  • 79.39 (n)
mouse
(Mus musculus)
Mammalia Pex11g 17 31 30
  • 78.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PEX11G 31
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PEX11G 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PEX11G 31 30
  • 63.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PEX11G 31
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pex11g 31 30
  • 58.08 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13827 31 30
  • 47.37 (n)
OneToMany
CG33474 31
  • 26 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003081 30
  • 46.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for PEX11G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PEX11G Gene

ENSEMBL:
Gene Tree for PEX11G (if available)
TreeFam:
Gene Tree for PEX11G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PEX11G: view image

Paralogs for PEX11G Gene

No data available for Paralogs for PEX11G Gene

Variants for PEX11G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PEX11G Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710139 Benign: not provided 7,477,288(-) C/CTA NONSENSE,INTRON_VARIANT
rs2303146 - p.Cys91Trp

Additional dbSNP identifiers (rs#s) for PEX11G Gene

Structural Variations from Database of Genomic Variants (DGV) for PEX11G Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv2400 CNV insertion 18451855
nsv509719 CNV insertion 20534489
nsv828416 CNV loss 20364138

Variation tolerance for PEX11G Gene

Gene Damage Index Score: 3.29; 53.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEX11G Gene

Human Gene Mutation Database (HGMD)
PEX11G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEX11G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEX11G Gene

Disorders for PEX11G Gene

MalaCards: The human disease database

(2) MalaCards diseases for PEX11G Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroxisome biogenesis disorder 1b
  • pbd1b
zellweger syndrome
  • zs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PEX11G

genes like me logo Genes that share disorders with PEX11G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEX11G Gene

Publications for PEX11G Gene

  1. cDNA cloning and characterization of the third isoform of human peroxin Pex11p. (PMID: 12559946) Tanaka A … Fujiki Y (Biochemical and biophysical research communications 2003) 3 4 23 54
  2. PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. (PMID: 12417726) Li X … Gould SJ (Molecular and cellular biology 2002) 2 3 4 54
  3. PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. (PMID: 20826455) Koch J … Brocard C (Journal of cell science 2010) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 54

Products for PEX11G Gene

Sources for PEX11G Gene