Aliases for PELO Gene
External Ids for PELO Gene
Previous GeneCards Identifiers for PELO Gene
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
GeneCards Summary for PELO Gene
PELO (Pelota MRNA Surveillance And Ribosome Rescue Factor) is a Protein Coding gene. Diseases associated with PELO include Angiokeratoma Of Fordyce and Achenbach Syndrome. Among its related pathways are Focal Adhesion and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include endonuclease activity.
UniProtKB/Swiss-Prot Summary for PELO Gene
Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).