Aliases for PELI2 Gene

Aliases for PELI2 Gene

  • Pellino E3 Ubiquitin Protein Ligase Family Member 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase Pellino Homolog 2 3 4
  • E3 Ubiquitin-Protein Ligase Pellino Homolog 2 3 4
  • Pellino-2 3 4
  • Pellino (Drosophila) Homolog 2 2
  • Pellino Homolog 2 (Drosophila) 2
  • Protein Pellino Homolog 2 3
  • Pellino Homolog 2 3
  • EC 2.3.2.27 4

External Ids for PELI2 Gene

Previous GeneCards Identifiers for PELI2 Gene

  • GC14P053909
  • GC14P050381
  • GC14P054575
  • GC14P055654
  • GC14P056585
  • GC14P036750

Summaries for PELI2 Gene

GeneCards Summary for PELI2 Gene

PELI2 (Pellino E3 Ubiquitin Protein Ligase Family Member 2) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is PELI1.

UniProtKB/Swiss-Prot Summary for PELI2 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Gene Wiki entry for PELI2 Gene

Additional gene information for PELI2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PELI2 Gene

Genomics for PELI2 Gene

GeneHancer (GH) Regulatory Elements for PELI2 Gene

Promoters and enhancers for PELI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J056115 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.8 +0.6 625 5.1 EP300 ZIC2 ZBTB10 ZBTB26 TRIM28 CTBP1 EZH2 FOXA2 KDM5B CTCF PELI2 ENSG00000277763 ENSG00000259483 piR-38352-172
GH14J056578 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 13.2 +462.4 462358 2.5 FOXK2 ZBTB40 ZNF217 EP300 CTCF TCF12 POLR2G SP1 BCLAF1 PHF8 TMEM260 PELI2 RF00017-1564 RF00994-325
GH14J056003 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas 19.4 -112.9 -112856 3.3 FOS ZIC2 BCL11A MYNN MEF2B TCF12 FOSL1 ZNF335 GLIS1 TBX21 LOC105370512 PELI2 piR-61240-101
GH14J056170 Enhancer 1 ENCODE dbSUPER 17.6 +54.4 54426 3.1 FOS ZNF639 TRIM28 JUN HINFP CEBPG FOSL2 MAFK PBX2 NFE2 PELI2 piR-38352-172 piR-55361-184
GH14J056195 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 15.7 +78.1 78100 1.7 NRF1 EP300 MYC ATF2 TCF12 REST USF2 GABPA MAX ARNT PELI2 piR-55361-184 piR-38352-172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PELI2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PELI2

Top Transcription factor binding sites by QIAGEN in the PELI2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for PELI2 Gene

Genomic Locations for PELI2 Gene
chr14:56,117,814-56,301,581
(GRCh38/hg38)
Size:
183,768 bases
Orientation:
Plus strand
chr14:56,584,532-56,768,244
(GRCh37/hg19)
Size:
183,713 bases
Orientation:
Plus strand

Genomic View for PELI2 Gene

Genes around PELI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PELI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PELI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELI2 Gene

Proteins for PELI2 Gene

  • Protein details for PELI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT8-PELI2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase pellino homolog 2
    Protein Accession:
    Q9HAT8
    Secondary Accessions:
    • B2RDY5

    Protein attributes for PELI2 Gene

    Size:
    420 amino acids
    Molecular mass:
    46435 Da
    Quaternary structure:
    • Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Interacts with BCL10; this interaction is impaired by SOCS3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PELI2 Gene

neXtProt entry for PELI2 Gene

Post-translational modifications for PELI2 Gene

  • Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity.
  • Ubiquitination at Lys164 and Lys268
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PELI2 Gene

Domains & Families for PELI2 Gene

Gene Families for PELI2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PELI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PELI2 Gene

GenScript: Design optimal peptide antigens:
  • Protein pellino homolog 2 (PELI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HAT8

UniProtKB/Swiss-Prot:

PELI2_HUMAN :
  • The atypical FHA domain contains a 'wing' insert and mediates binding to threonine-phosphorylated IRAK1.
  • Belongs to the pellino family.
Domain:
  • The atypical FHA domain contains a 'wing' insert and mediates binding to threonine-phosphorylated IRAK1.
Family:
  • Belongs to the pellino family.
genes like me logo Genes that share domains with PELI2: view

Function for PELI2 Gene

Molecular function for PELI2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for PELI2 Gene

Phenotypes From GWAS Catalog for PELI2 Gene

Gene Ontology (GO) - Molecular Function for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12860405
GO:0016740 transferase activity IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity TAS --
GO:0061630 ubiquitin protein ligase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with PELI2: view
genes like me logo Genes that share phenotypes with PELI2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PELI2 Gene

Localization for PELI2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PELI2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 0
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PELI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PELI2 Gene

Pathways & Interactions for PELI2 Gene

genes like me logo Genes that share pathways with PELI2: view

UniProtKB/Swiss-Prot Q9HAT8-PELI2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for PELI2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0001934 positive regulation of protein phosphorylation IDA 12804775
GO:0008063 Toll signaling pathway IBA 21873635
GO:0008592 regulation of Toll signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with PELI2: view

Drugs & Compounds for PELI2 Gene

No Compound Related Data Available

Transcripts for PELI2 Gene

mRNA/cDNA for PELI2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PELI2 Gene

No ASD Table

Relevant External Links for PELI2 Gene

GeneLoc Exon Structure for
PELI2

Expression for PELI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PELI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PELI2

SOURCE GeneReport for Unigene cluster for PELI2 Gene:

Hs.657926

Evidence on tissue expression from TISSUES for PELI2 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with PELI2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PELI2 Gene

Orthologs for PELI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PELI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PELI2 31 30
  • 99.6 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PELI2 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELI2 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PELI2 31 30
  • 90.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Peli2 17 31 30
  • 87.03 (n)
rat
(Rattus norvegicus)
Mammalia Peli2 30
  • 86.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PELI2 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PELI2 31 30
  • 82.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PELI2 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia peli1 30
  • 77.72 (n)
MGC75650 30
zebrafish
(Danio rerio)
Actinopterygii peli2 31 30
  • 73.17 (n)
OneToOne
Dr.12828 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004232 30
  • 61.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pli 31 32 30
  • 61.35 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F25B4.2 30
  • 50.29 (n)
F25B4.2 31 32
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 56 (a)
OneToMany
Species where no ortholog for PELI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PELI2 Gene

ENSEMBL:
Gene Tree for PELI2 (if available)
TreeFam:
Gene Tree for PELI2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PELI2: view image

Paralogs for PELI2 Gene

Paralogs for PELI2 Gene

(2) SIMAP similar genes for PELI2 Gene using alignment to 3 proteins:

  • PELI2_HUMAN
  • H0YK56_HUMAN
  • H0YNF4_HUMAN
genes like me logo Genes that share paralogs with PELI2: view

Variants for PELI2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PELI2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
771903 Benign: not provided 56,290,386(+) G/A MISSENSE_VARIANT
777693 Benign: not provided 56,296,737(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PELI2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PELI2 Gene

Variant ID Type Subtype PubMed ID
dgv1267e59 CNV tandem duplication 20981092
esv1586377 CNV insertion 17803354
esv2676142 CNV deletion 23128226
esv3305519 CNV mobile element insertion 20981092
esv3345549 CNV duplication 20981092
esv3581210 CNV loss 25503493
esv989258 CNV insertion 20482838
nsv1142848 CNV tandem duplication 24896259
nsv1143751 CNV deletion 24896259
nsv479046 CNV novel sequence insertion 20440878
nsv519617 CNV gain 19592680

Variation tolerance for PELI2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PELI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PELI2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELI2 Gene

Disorders for PELI2 Gene

Additional Disease Information for PELI2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PELI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PELI2 Gene

Publications for PELI2 Gene

  1. Characterization of Pellino2, a substrate of IRAK1 and IRAK4. (PMID: 12860405) Strelow A … Wesche H (FEBS letters 2003) 2 3 4 54
  2. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PMID: 11306823) Resch K … Schmitt-John T (Cytogenetics and cell genetics 2001) 2 3 4 54
  3. Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. (PMID: 22669975) Kim TW … Li X (The Journal of biological chemistry 2012) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A … Cohen P (The Biochemical journal 2008) 3 4 54

Products for PELI2 Gene

Sources for PELI2 Gene