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PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with PELI1 include Tyrosinemia, Type Iii. Among its related pathways are Diseases associated with the TLR signaling cascade and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 12496252 |
GO:0016740 | transferase activity | IEA | -- |
GO:0034450 | ubiquitin-ubiquitin ligase activity | TAS | -- |
GO:0061630 | ubiquitin protein ligase activity | IBA,IDA | 29883609 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000778 | condensed nuclear chromosome kinetochore | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Innate Immune System |
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4 | IL-1 signaling pathway | ||
5 | Diseases associated with the TLR signaling cascade |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IBA | 21873635 |
GO:0001819 | positive regulation of cytokine production | IEA | -- |
GO:0008063 | Toll signaling pathway | IBA | 21873635 |
GO:0008592 | regulation of Toll signaling pathway | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | ||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PELI1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PELI1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PELI1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PELI1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PELI1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Peli1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Peli1 30 |
|
||
Chicken (Gallus gallus) |
Aves | PELI1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PELI1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | peli2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | peli1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | peli1b 30 31 |
|
OneToMany | |
peli1a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pli 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F25B4.2 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv151e55 | CNV | gain | 17911159 |
dgv3861n100 | CNV | gain | 25217958 |
dgv705e214 | CNV | gain | 21293372 |
esv2759055 | CNV | gain | 17122850 |
esv29437 | CNV | gain | 19812545 |
esv3302963 | CNV | tandem duplication | 20981092 |
nsv1006553 | CNV | gain | 25217958 |
nsv1013132 | CNV | loss | 25217958 |
nsv428396 | CNV | gain | 18775914 |
nsv582126 | CNV | gain | 21841781 |
nsv582127 | CNV | gain | 21841781 |
nsv7313 | OTHER | inversion | 18451855 |
nsv834243 | CNV | gain+loss | 17160897 |
nsv9957 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
tyrosinemia, type iii |
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