Aliases for PELI1 Gene
External Ids for PELI1 Gene
Previous GeneCards Identifiers for PELI1 Gene
GeneCards Summary for PELI1 Gene
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with PELI1 include Tyrosinemia, Type Iii. Among its related pathways are Diseases associated with the TLR signaling cascade and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2.
UniProtKB/Swiss-Prot Summary for PELI1 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).