Aliases for PELI1 Gene
External Ids for PELI1 Gene
Previous GeneCards Identifiers for PELI1 Gene
GeneCards Summary for PELI1 Gene
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2.
UniProtKB/Swiss-Prot Summary for PELI1 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).