The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the cata... See more...

Aliases for PEDS1-UBE2V1 Gene

Aliases for PEDS1-UBE2V1 Gene

  • PEDS1-UBE2V1 Readthrough 2 3 5 13
  • CROC-1B 2 3
  • Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1 Read-Through 3
  • TMEM189-UBE2V1 Readthrough Transcript 3
  • TMEM189-UBE2V1 Fusion Protein 3
  • TMEM189-UBE2V1 Readthrough 2
  • TMEM189-UBE2V1 3
  • PEDS1-UBE2V1 5
  • HCG2044781 13
  • KUA-UEV 3
  • Kua-UEV 2
  • CROC1B 3

External Ids for PEDS1-UBE2V1 Gene

Previous HGNC Symbols for PEDS1-UBE2V1 Gene

  • TMEM189-UBE2V1

Summaries for PEDS1-UBE2V1 Gene

Entrez Gene Summary for PEDS1-UBE2V1 Gene

  • The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for PEDS1-UBE2V1 Gene

PEDS1-UBE2V1 (PEDS1-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and Metabolism. An important paralog of this gene is PEDS1.

Gene Wiki entry for PEDS1-UBE2V1 Gene

Additional gene information for PEDS1-UBE2V1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PEDS1-UBE2V1 Gene

Genomics for PEDS1-UBE2V1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PEDS1-UBE2V1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PEDS1-UBE2V1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PEDS1-UBE2V1

Genomic Locations for PEDS1-UBE2V1 Gene

Latest Assembly
chr20:50,081,124-50,153,723
(GRCh38/hg38)
Size:
72,600 bases
Orientation:
Minus strand

Previous Assembly
chr20:48,697,661-48,770,260
(GRCh37/hg19 by Entrez Gene)
Size:
72,600 bases
Orientation:
Minus strand

chr20:48,697,661-48,770,174
(GRCh37/hg19 by Ensembl)
Size:
72,514 bases
Orientation:
Minus strand

Genomic View for PEDS1-UBE2V1 Gene

Genes around PEDS1-UBE2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEDS1-UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEDS1-UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEDS1-UBE2V1 Gene

Proteins for PEDS1-UBE2V1 Gene

  • Protein details for PEDS1-UBE2V1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    I3L0A0-I3L0A0_HUMAN
    Recommended name:
    HCG2044781
    Protein Accession:
    I3L0A0

    Protein attributes for PEDS1-UBE2V1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PEDS1-UBE2V1 Gene

Post-translational modifications for PEDS1-UBE2V1 Gene

No Post-translational modifications

Other Protein References for PEDS1-UBE2V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PEDS1-UBE2V1 Gene

Domains & Families for PEDS1-UBE2V1 Gene

Gene Families for PEDS1-UBE2V1 Gene

Unknown:
  • Belongs to the fatty acid desaturase CarF family.
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PEDS1-UBE2V1 Gene

genes like me logo Genes that share domains with PEDS1-UBE2V1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PEDS1-UBE2V1 Gene

Function for PEDS1-UBE2V1 Gene

Phenotypes From GWAS Catalog for PEDS1-UBE2V1 Gene

Gene Ontology (GO) - Molecular Function for PEDS1-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with PEDS1-UBE2V1: view
genes like me logo Genes that share phenotypes with PEDS1-UBE2V1: view

miRNA for PEDS1-UBE2V1 Gene

miRTarBase miRNAs that target PEDS1-UBE2V1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PEDS1-UBE2V1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEDS1-UBE2V1 Gene

Localization for PEDS1-UBE2V1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PEDS1-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PEDS1-UBE2V1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PEDS1-UBE2V1 Gene

Pathways & Interactions for PEDS1-UBE2V1 Gene

PathCards logo

SuperPathways for PEDS1-UBE2V1 Gene

genes like me logo Genes that share pathways with PEDS1-UBE2V1: view

Pathways by source for PEDS1-UBE2V1 Gene

1 BioSystems pathway for PEDS1-UBE2V1 Gene
2 KEGG pathways for PEDS1-UBE2V1 Gene

UniProtKB/Swiss-Prot I3L0A0-I3L0A0_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Interacting Proteins for PEDS1-UBE2V1 Gene

Gene Ontology (GO) - Biological Process for PEDS1-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with PEDS1-UBE2V1: view

No data available for SIGNOR curated interactions for PEDS1-UBE2V1 Gene

Drugs & Compounds for PEDS1-UBE2V1 Gene

No Compound Related Data Available

Transcripts for PEDS1-UBE2V1 Gene

mRNA/cDNA for PEDS1-UBE2V1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PEDS1-UBE2V1

Alternative Splicing Database (ASD) splice patterns (SP) for PEDS1-UBE2V1 Gene

No ASD Table

Relevant External Links for PEDS1-UBE2V1 Gene

GeneLoc Exon Structure for
PEDS1-UBE2V1

Expression for PEDS1-UBE2V1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PEDS1-UBE2V1

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEDS1-UBE2V1 Gene

Orthologs for PEDS1-UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PEDS1-UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Gm20431 31
  • 92 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia TMEM189 31
  • 88 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 83 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TMEM189 31
  • 82 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia TMEM189 31
  • 66 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM189 31
  • 63 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TMEM189 31
  • 70 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 51 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii tmem189 31
  • 60 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kua 31
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y53C10A.5 31
  • 37 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MMZ1 30
  • 56.3 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0712300 30
  • 55.47 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Species where no ortholog for PEDS1-UBE2V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PEDS1-UBE2V1 Gene

ENSEMBL:
Gene Tree for PEDS1-UBE2V1 (if available)
TreeFam:
Gene Tree for PEDS1-UBE2V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PEDS1-UBE2V1: view image

Paralogs for PEDS1-UBE2V1 Gene

genes like me logo Genes that share paralogs with PEDS1-UBE2V1: view

Variants for PEDS1-UBE2V1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PEDS1-UBE2V1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs73598393 Benign: not provided 50,082,792(-) G/A
NM_001032288.3(UBE2V1):c.420C>T (p.Pro140=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PEDS1-UBE2V1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PEDS1-UBE2V1 Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV loss 18971310
esv3646041 CNV loss 21293372
nsv1061982 CNV loss 25217958
nsv1072546 CNV deletion 25765185
nsv1078793 CNV insertion 25765185
nsv474090 CNV novel sequence insertion 20440878
nsv833999 CNV loss 17160897
nsv834000 CNV gain+loss 17160897
nsv964407 CNV duplication 23825009

Variation tolerance for PEDS1-UBE2V1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEDS1-UBE2V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEDS1-UBE2V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEDS1-UBE2V1 Gene

Disorders for PEDS1-UBE2V1 Gene

Additional Disease Information for PEDS1-UBE2V1

Open Targets Platform
Open Targets Platform

No disorders were found for PEDS1-UBE2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PEDS1-UBE2V1 Gene

Publications for PEDS1-UBE2V1 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson TM … Guigó R (Genome research 2000) 2 3 23
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3
  5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3

Products for PEDS1-UBE2V1 Gene

Sources for PEDS1-UBE2V1 Gene