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Aliases for PECR Gene

Aliases for PECR Gene

  • Peroxisomal Trans-2-Enoyl-CoA Reductase 2 3 3 5
  • Short Chain Dehydrogenase/Reductase Family 29C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase-Related Protein 3 4
  • SDR29C1 3 4
  • PVI-ARL 3 4
  • DCR-RP 3 4
  • TERP 3 4
  • Short Chain Dehydrogenase/Reductase Family 29C, Member 1 2
  • Putative Short Chain Alcohol Dehydrogenase 3
  • EC 1.3.1.38 4
  • HSA250303 3
  • HPDHASE 3
  • HPDHase 4
  • PVIARL 3
  • DCRRP 3

External Ids for PECR Gene

Previous GeneCards Identifiers for PECR Gene

  • GC02M215065
  • GC02M215627
  • GC02M216867
  • GC02M217105
  • GC02M216728
  • GC02M216611
  • GC02M208760

Summaries for PECR Gene

GeneCards Summary for PECR Gene

PECR (Peroxisomal Trans-2-Enoyl-CoA Reductase) is a Protein Coding gene. Among its related pathways are Metabolism and Allograft rejection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coenzyme binding. An important paralog of this gene is DECR1.

UniProtKB/Swiss-Prot for PECR Gene

  • Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.

Gene Wiki entry for PECR Gene

Additional gene information for PECR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECR Gene

Genomics for PECR Gene

GeneHancer (GH) Regulatory Elements for PECR Gene

Promoters and enhancers for PECR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J216080 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.4 -367 5.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PECR TMEM169 XRCC5 LINC01963 SMARCAL1
GH02J216000 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13 +80.7 80712 2.7 HDGF FOXA2 RB1 YBX1 BATF ZNF366 RUNX3 GATAD2B ZNF592 SP1 XRCC5 PECR TMEM169 SMARCAL1 MREG GC02M216014 ENSG00000226276
GH02J216031 Enhancer 1 ENCODE dbSUPER 16.8 +50.7 50728 1.2 PKNOX1 BACH1 BATF IRF4 RELA ZNF366 NFATC1 ATF7 FOS ETV6 MREG PECR XRCC5 TMEM169 GC02M216014
GH02J216011 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +70.2 70197 3.2 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZNF48 ETS1 GLIS2 ZNF143 ATF7 XRCC5 MREG PECR GC02M216014 ENSG00000226276
GH02J216186 Enhancer 1.1 Ensembl ENCODE 10.2 -105.5 -105514 3 FOXA2 ARNT NCOA2 TCF12 ZNF766 FOS RXRA NCOA1 REST ZNF592 XRCC5 ENSG00000231092 TMEM169 PECR ENSG00000241520 LOC100421349 ENSG00000279348
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PECR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PECR gene promoter:
  • p53
  • p300
  • C/EBPalpha
  • CUTL1
  • PPAR-alpha
  • LCR-F1
  • LHX3b
  • Lhx3a
  • IRF-2
  • ATF6

Genomic Locations for PECR Gene

Genomic Locations for PECR Gene
chr2:215,996,329-216,082,955
(GRCh38/hg38)
Size:
86,627 bases
Orientation:
Minus strand
chr2:216,861,052-216,947,678
(GRCh37/hg19)
Size:
86,627 bases
Orientation:
Minus strand

Genomic View for PECR Gene

Genes around PECR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PECR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PECR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECR Gene

Proteins for PECR Gene

  • Protein details for PECR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY49-PECR_HUMAN
    Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase
    Protein Accession:
    Q9BY49
    Secondary Accessions:
    • B2RE42
    • Q53TC4
    • Q6IAK9
    • Q9NRD4
    • Q9NY60
    • Q9P1A4

    Protein attributes for PECR Gene

    Size:
    303 amino acids
    Molecular mass:
    32544 Da
    Quaternary structure:
    • Interacts with PEX5, probably required to target it into peroxisomes.
    SequenceCaution:
    • Sequence=AAF69798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PECR Gene

    Alternative splice isoforms for PECR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PECR Gene

Post-translational modifications for PECR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PECR Gene

No data available for DME Specific Peptides for PECR Gene

Domains & Families for PECR Gene

Gene Families for PECR Gene

Suggested Antigen Peptide Sequences for PECR Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY49

UniProtKB/Swiss-Prot:

PECR_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with PECR: view

Function for PECR Gene

Molecular function for PECR Gene

UniProtKB/Swiss-Prot Function:
Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Induction:
Not induced by IR.

Enzyme Numbers (IUBMB) for PECR Gene

Phenotypes From GWAS Catalog for PECR Gene

Gene Ontology (GO) - Molecular Function for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 11669066
GO:0008670 NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA 11669066
GO:0016491 oxidoreductase activity IEA --
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity IDA,EXP 16546181
genes like me logo Genes that share ontologies with PECR: view
genes like me logo Genes that share phenotypes with PECR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PECR

Clone Products

  • Addgene plasmids for PECR

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PECR Gene

Localization for PECR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECR Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PECR gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA,IDA 11669066
GO:0005778 peroxisomal membrane TAS --
genes like me logo Genes that share ontologies with PECR: view

Pathways & Interactions for PECR Gene

genes like me logo Genes that share pathways with PECR: view

UniProtKB/Swiss-Prot Q9BY49-PECR_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0033306 phytol metabolic process IDA 16546181
genes like me logo Genes that share ontologies with PECR: view

No data available for SIGNOR curated interactions for PECR Gene

Drugs & Compounds for PECR Gene

(4) Drugs for PECR Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenine Approved Nutra Target 0
Hexanoyl-CoA Experimental Pharma 0
myristoyl-coa Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(33) Additional Compounds for PECR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with PECR: view

Transcripts for PECR Gene

mRNA/cDNA for PECR Gene

Unigene Clusters for PECR Gene

Peroxisomal trans-2-enoyl-CoA reductase:
Representative Sequences:

Clone Products

  • Addgene plasmids for PECR

Alternative Splicing Database (ASD) splice patterns (SP) for PECR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for PECR Gene

GeneLoc Exon Structure for
PECR
ECgene alternative splicing isoforms for
PECR

Expression for PECR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PECR Gene

mRNA differential expression in normal tissues according to GTEx for PECR Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for PECR Gene

This gene is overexpressed in Liver (27.2), Fetal Liver (13.4), and Nasopharynx (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PECR Gene



NURSA nuclear receptor signaling pathways regulating expression of PECR Gene:

PECR

SOURCE GeneReport for Unigene cluster for PECR Gene:

Hs.281680

Evidence on tissue expression from TISSUES for PECR Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Gall bladder(2.1)
  • Lung(2.1)
  • Thyroid gland(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PECR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PECR Gene

Orthologs for PECR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PECR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PECR 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PECR 34 33
  • 81.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PECR 34 33
  • 81.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pecr 16 34 33
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Pecr 33
  • 77.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PECR 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PECR 34 33
  • 65.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PECR 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pecr 33
  • 62.17 (n)
zebrafish
(Danio rerio)
Actinopterygii pecr 34 33
  • 60.73 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14009 33
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15521g 33
  • 46.52 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 34
  • 32 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os11g0443700 33
  • 49.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToOne
Cin.2168 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2168 33
Species where no ortholog for PECR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECR Gene

ENSEMBL:
Gene Tree for PECR (if available)
TreeFam:
Gene Tree for PECR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PECR: view image

Paralogs for PECR Gene

Paralogs for PECR Gene

(7) SIMAP similar genes for PECR Gene using alignment to 2 proteins:

  • PECR_HUMAN
  • B4DJS2_HUMAN
genes like me logo Genes that share paralogs with PECR: view

Variants for PECR Gene

Sequence variations from dbSNP and Humsavar for PECR Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000016210 -- 216,037,689(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000047597 -- 216,036,222(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000060809 -- 216,060,430(-) G/A intron_variant
rs1000201554 -- 216,053,809(-) C/T intron_variant
rs1000365963 -- 216,047,934(-) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PECR Gene

Variant ID Type Subtype PubMed ID
esv2658029 CNV deletion 23128226
esv3594289 CNV loss 21293372
nsv1011506 CNV gain 25217958
nsv998837 CNV gain 25217958

Variation tolerance for PECR Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PECR Gene

Human Gene Mutation Database (HGMD)
PECR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PECR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PECR Gene

Disorders for PECR Gene

Additional Disease Information for PECR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PECR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PECR Gene

Publications for PECR Gene

  1. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. (PMID: 11937624) Braastad CD … Hendrickson EA (Nucleic acids research 2002) 3 4 22 58
  2. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. (PMID: 11669066) Amery L … Fransen M (Combinatorial chemistry & high throughput screening 2001) 2 3 4 58
  3. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. (PMID: 10811639) Das AK … Hajra AK (The Journal of biological chemistry 2000) 2 3 4 58
  4. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PMID: 20463177) Hersh CP … Silverman EK (American journal of respiratory and critical care medicine 2010) 3 44 58
  5. Genome-wide association study of alcohol dependence. (PMID: 19581569) Treutlein J … Rietschel M (Archives of general psychiatry 2009) 3 44 58

Products for PECR Gene

  • Addgene plasmids for PECR

Sources for PECR Gene

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