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Aliases for PEBP4 Gene

Aliases for PEBP4 Gene

  • Phosphatidylethanolamine Binding Protein 4 2 3 5
  • Protein Cousin-Of-RKIP 1 3 4
  • Cousin-Of-RKIP 1 Protein 2 3
  • PEBP-4 3 4
  • HPEBP4 3 4
  • CORK1 3 4
  • Phosphatidylethanolamine-Binding Protein 4 3
  • Epididymis Secretory Protein Li 300 3
  • HEL-S-300 3
  • GWTM1933 3
  • PRO4408 3
  • CORK-1 3

External Ids for PEBP4 Gene

Previous GeneCards Identifiers for PEBP4 Gene

  • GC08M022626
  • GC08M022570
  • GC08M021113

Summaries for PEBP4 Gene

Entrez Gene Summary for PEBP4 Gene

  • The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]

GeneCards Summary for PEBP4 Gene

PEBP4 (Phosphatidylethanolamine Binding Protein 4) is a Protein Coding gene. Diseases associated with PEBP4 include Lung Squamous Cell Carcinoma. An important paralog of this gene is PEBP1.

UniProtKB/Swiss-Prot for PEBP4 Gene

  • Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.

Additional gene information for PEBP4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEBP4 Gene

Genomics for PEBP4 Gene

GeneHancer (GH) Regulatory Elements for PEBP4 Gene

Promoters and enhancers for PEBP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022998 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -1.7 -1664 5.9 HDGF ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 RUNX3 SP3 YY2 RHOBTB2 PEBP4 EGR3 ENSG00000251034 PIR37908 ENSG00000245025
GH08J022927 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 699.7 +71.9 71935 1 SP1 RXRA HLF HNF4A PEBP4 RHOBTB2 LOC101929237 BIN3 GC08P022948 ENSG00000253142
GH08J022997 Enhancer 1 FANTOM5 ENCODE dbSUPER 650.7 +1.8 1807 0.4 PKNOX1 ZNF207 MEF2B ELF1 KLF5 ATF2 RUNX3 PEBP4 EGR3 RHOBTB2 ENSG00000245025
GH08J022920 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 44.5 +77.6 77580 2.9 KLF1 CEBPG IRF9 ZNF121 FOSL1 ZFHX2 GATA3 EGR1 FOS EGR2 PEBP4 RHOBTB2 LOC101929237 BIN3 CHMP7 ENSG00000253142 GC08P022948
GH08J022915 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.3 +82.9 82933 4.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 FOS DEK PEBP4 LOC101929237 RHOBTB2 BIN3 CHMP7 ENSG00000253142 GC08P022948
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PEBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PEBP4 gene promoter:
  • Nkx2-5
  • Lmo2
  • RREB-1
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • AREB6
  • c-Myb
  • Arnt
  • AhR

Genomic Locations for PEBP4 Gene

Genomic Locations for PEBP4 Gene
chr8:22,713,251-23,000,000
(GRCh38/hg38)
Size:
286,750 bases
Orientation:
Minus strand
chr8:22,570,765-22,857,513
(GRCh37/hg19)
Size:
286,749 bases
Orientation:
Minus strand

Genomic View for PEBP4 Gene

Genes around PEBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEBP4 Gene

Proteins for PEBP4 Gene

  • Protein details for PEBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S96-PEBP4_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 4
    Protein Accession:
    Q96S96
    Secondary Accessions:
    • Q5EVA1
    • Q8WW74

    Protein attributes for PEBP4 Gene

    Size:
    227 amino acids
    Molecular mass:
    25733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20779.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305}; Sequence=AAQ89467.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305};

neXtProt entry for PEBP4 Gene

Post-translational modifications for PEBP4 Gene

No Post-translational modifications

Other Protein References for PEBP4 Gene

No data available for DME Specific Peptides for PEBP4 Gene

Domains & Families for PEBP4 Gene

Gene Families for PEBP4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PEBP4 Gene

Suggested Antigen Peptide Sequences for PEBP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S96

UniProtKB/Swiss-Prot:

PEBP4_HUMAN :
  • Belongs to the phosphatidylethanolamine-binding protein family.
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP4: view

Function for PEBP4 Gene

Molecular function for PEBP4 Gene

UniProtKB/Swiss-Prot Function:
Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.

Phenotypes From GWAS Catalog for PEBP4 Gene

Gene Ontology (GO) - Molecular Function for PEBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19197339
genes like me logo Genes that share ontologies with PEBP4: view
genes like me logo Genes that share phenotypes with PEBP4: view

Animal Model Products

miRNA for PEBP4 Gene

miRTarBase miRNAs that target PEBP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP4 Gene

Localization for PEBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP4 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEBP4 gene
Compartment Confidence
extracellular 5
lysosome 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PEBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PEBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PEBP4 Gene

Pathways & Interactions for PEBP4 Gene

SuperPathways for PEBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PEBP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PEBP4 Gene

Drugs & Compounds for PEBP4 Gene

(2) Drugs for PEBP4 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 387

(7) Additional Compounds for PEBP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 1-(Hexadec-1-enyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • PE(P-16:0/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1W7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
88542-95-4
genes like me logo Genes that share compounds with PEBP4: view

Transcripts for PEBP4 Gene

mRNA/cDNA for PEBP4 Gene

Unigene Clusters for PEBP4 Gene

Phosphatidylethanolamine-binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP4 Gene

No ASD Table

Relevant External Links for PEBP4 Gene

GeneLoc Exon Structure for
PEBP4
ECgene alternative splicing isoforms for
PEBP4

Expression for PEBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PEBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP4 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.8), Muscle - Skeletal (x11.7), Heart - Atrial Appendage (x8.9), and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for PEBP4 Gene

This gene is overexpressed in Serum (28.4), Vitreous humor (17.2), and Cerebrospinal fluid (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PEBP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of PEBP4 Gene:

PEBP4

SOURCE GeneReport for Unigene cluster for PEBP4 Gene:

Hs.491242

mRNA Expression by UniProt/SwissProt for PEBP4 Gene:

Q96S96-PEBP4_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in tumor cells.

Evidence on tissue expression from TISSUES for PEBP4 Gene

  • Lung(4.5)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PEBP4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEBP4 Gene

Orthologs for PEBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PEBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEBP4 34 33
  • 98.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PEBP4 34 33
  • 81.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PEBP4 34 33
  • 80.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pebp4 33
  • 66.67 (n)
mouse
(Mus musculus)
Mammalia Pebp4 16 34 33
  • 65.98 (n)
oppossum
(Monodelphis domestica)
Mammalia PEBP4 34
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 11 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pebp4 33
  • 52.16 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882266 33
  • 53.23 (n)
PEBP4 34
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30060 34
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y69E1A.5 34
  • 24 (a)
OneToOne
Species where no ortholog for PEBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEBP4 Gene

ENSEMBL:
Gene Tree for PEBP4 (if available)
TreeFam:
Gene Tree for PEBP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PEBP4: view image

Paralogs for PEBP4 Gene

Paralogs for PEBP4 Gene

genes like me logo Genes that share paralogs with PEBP4: view

Variants for PEBP4 Gene

Sequence variations from dbSNP and Humsavar for PEBP4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000013560 -- 22,853,793(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000014727 -- 22,725,732(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000020429 -- 22,926,178(-) G/A intron_variant
rs1000034078 -- 22,748,405(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000042789 -- 22,899,980(-) AAGAAG/AAG genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PEBP4 Gene

Variant ID Type Subtype PubMed ID
dgv12056n54 CNV loss 21841781
esv2027896 CNV deletion 18987734
esv2759604 CNV loss 17122850
esv3325133 CNV insertion 20981092
esv3572634 CNV loss 25503493
esv988282 CNV insertion 20482838
nsv1020839 CNV gain 25217958
nsv1025583 CNV gain 25217958
nsv1025672 CNV gain 25217958
nsv1027718 CNV gain 25217958
nsv396765 CNV insertion 16902084
nsv477093 CNV novel sequence insertion 20440878
nsv517319 CNV loss 19592680
nsv523385 CNV loss 19592680
nsv831267 CNV gain 17160897

Variation tolerance for PEBP4 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.70; 95.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEBP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEBP4 Gene

Disorders for PEBP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PEBP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search PEBP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PEBP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PEBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEBP4 Gene

Publications for PEBP4 Gene

  1. A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. (PMID: 15302887) Wang X … Cao X (The Journal of biological chemistry 2004) 2 3 4 22 58
  2. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. (PMID: 16865237) Li P … Cao X (International journal of molecular medicine 2006) 2 3 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Regulation of human myoblast differentiation by PEBP4. (PMID: 19197339) Garcia R … Kolch W (EMBO reports 2009) 3 22 58

Products for PEBP4 Gene

Sources for PEBP4 Gene

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