PEBP1 Gene (Protein Coding)

Phosphatidylethanolamine Binding Protein 1

GC12P118135
GIFtS:
46
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide ... See more...

Aliases for PEBP1 Gene

Aliases for PEBP1 Gene

  • Phosphatidylethanolamine Binding Protein 1 2 3 5
  • Hippocampal Cholinergic Neurostimulating Peptide 2 3
  • Phosphatidylethanolamine-Binding Protein 1 3 4
  • Raf Kinase Inhibitory Protein 2 3
  • Raf Kinase Inhibitor Protein 3 4
  • Prostatic Binding Protein 2 3
  • Neuropolypeptide H3 3 4
  • HCNPpp 3 4
  • PEBP-1 3 4
  • PEBP 3 4
  • RKIP 3 4
  • PBP 3 4
  • Epididymis Secretory Protein Li 34 3
  • Epididymis Secretory Protein Li 96 3
  • Epididymis Luminal Protein 210 3
  • Prostatic-Binding Protein 4
  • HEL-S-34 3
  • HEL-S-96 3
  • HEL-210 3
  • HCNP 3

External Ids for PEBP1 Gene

Previous HGNC Symbols for PEBP1 Gene

  • PBP

Previous GeneCards Identifiers for PEBP1 Gene

  • GC12P117058
  • GC12P118573
  • GC12P115583

Summaries for PEBP1 Gene

Entrez Gene Summary for PEBP1 Gene

  • This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

GeneCards Summary for PEBP1 Gene

PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Myeloid Sarcoma and Prostate Cancer. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is PEBP4.

UniProtKB/Swiss-Prot Summary for PEBP1 Gene

  • Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
  • HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Wiki entry for PEBP1 Gene

Additional gene information for PEBP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PEBP1 Gene

Genomics for PEBP1 Gene

GeneHancer (GH) Regulatory Elements for PEBP1 Gene

Promoters and enhancers for PEBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J118134 Promoter/Enhancer 1.7 EPDnew ENCODE CraniofacialAtlas 506.5 +1.4 1381 5.3 SIN3A NRF1 POLR2G SP1 NCOR1 PHF8 ZFX CTCF ZIC2 POLR2A VSIG10 PEBP1 LOC101928274 piR-43107-077 lnc-TAOK3-1-002 SUDS3 RFC5 WSB2 lnc-TAOK3-9
GH12J118370 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 +238.1 238098 8.7 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC POLR2G SUDS3 TAOK3 lnc-VSIG10-4 RFC5 PEBP1 ENSG00000270482
GH12J118355 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.4 +221.6 221645 5.3 ZBTB40 CTCF TCF12 PHB2 ZNF10 AFF1 TRIM28 TARDBP DNMT1 HES1 TAOK3 SUDS3 RFC5 PEBP1 HE856110 lnc-VSIG10-4
GH12J118187 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 6.6 +53.1 53142 3.6 USF1 REST CTBP1 MXI1 POLR2A NCOR1 MEF2B SPI1 TAL1 ZFP91 HSALNG0094417 KSR2 PEBP1 VSIG10 lnc-VSIG10-1 TAOK3
GH12J118236 Enhancer 0.7 ENCODE 9.4 +101.9 101876 2.8 EP300 TRIM22 BCL11A FOS ARNT MEF2B NBN SPI1 GATA3 ELF1 PEBP1 SUDS3 RPS2P5 lnc-VSIG10-3 TAOK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PEBP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PEBP1

Top Transcription factor binding sites by QIAGEN in the PEBP1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PEBP1 Gene

Genomic Locations for PEBP1 Gene
chr12:118,136,065-118,145,585
(GRCh38/hg38)
Size:
9,521 bases
Orientation:
Plus strand
chr12:118,573,663-118,583,390
(GRCh37/hg19)
Size:
9,728 bases
Orientation:
Plus strand

Genomic View for PEBP1 Gene

Genes around PEBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEBP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PEBP1 Gene

Proteins for PEBP1 Gene

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  • Protein details for PEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30086-PEBP1_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 1
    Protein Accession:
    P30086
    Secondary Accessions:
    • B2R4S1

    Protein attributes for PEBP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21057 Da
    Quaternary structure:
    • Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for PEBP1 Gene

neXtProt entry for PEBP1 Gene

Protein Expression for PEBP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PEBP1 Gene

  • Ubiquitination at Lys7, Lys47, Lys113, and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for PEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PEBP1 Gene

Domains & Families for PEBP1 Gene

Gene Families for PEBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PEBP1 Gene

Blocks:
  • Phosphatidylethanolamine-binding protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PEBP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51535, highly similar to Phosphatidylethanolamine-binding protein 1 (B4DRT4_HUMAN)
  • Raf kinase inhibitor protein (PEBP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30086

UniProtKB/Swiss-Prot:

PEBP1_HUMAN :
  • Belongs to the phosphatidylethanolamine-binding protein family.
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP1: view

Function for PEBP1 Gene

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  2. CRISPR
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Molecular function for PEBP1 Gene

UniProtKB/Swiss-Prot Function:
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
UniProtKB/Swiss-Prot Function:
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Phenotypes From GWAS Catalog for PEBP1 Gene

Gene Ontology (GO) - Molecular Function for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 17097642
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PEBP1: view
genes like me logo Genes that share phenotypes with PEBP1: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PEBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP1 Gene

Localization for PEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEBP1 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PEBP1: view

Pathways & Interactions for PEBP1 Gene

PathCards logo

SuperPathways for PEBP1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
MAP2K and MAPK activation
.90
Paradoxical activation of RAF signaling by kinase inactive BRAF
.90
Signaling by high-kinase activity BRAF mutants
.90
Signaling by moderate kinase activity BRAF mutants
.90
Signaling by RAS mutants
.78
3 Developmental Biology
Axon guidance
.51
Developmental Biology
.51
4 Cytokine Signaling in Immune system
Cytokine Signaling in Immune system
.69
Signaling by Interleukins
.69
5 HIV Life Cycle
Disease
.45
Diseases of signal transduction
.43
genes like me logo Genes that share pathways with PEBP1: view

Pathways by source for PEBP1 Gene

1 Qiagen pathway for PEBP1 Gene
  • Phospholipase-C Pathway
1 Cell Signaling Technology pathway for PEBP1 Gene

SIGNOR curated interactions for PEBP1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0043409 negative regulation of MAPK cascade IBA 21873635
genes like me logo Genes that share ontologies with PEBP1: view

Drugs & Compounds for PEBP1 Gene

Products:

  1. Drug

(12) Drugs for PEBP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 236
Omega-3-carboxylic acids Approved, Investigational Pharma Carrier, binder 0
Methicillin Acyl-Serine Experimental Pharma Target 0
Nitrocefin Acyl-Serine Experimental Pharma Target 0
Penicillin G Acyl-Serine Experimental Pharma Target 0

(12) Additional Compounds for PEBP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 1-(Hexadec-1-enyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • PE(P-16:0/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1W7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
 68737-67-7
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
 88542-95-4
genes like me logo Genes that share compounds with PEBP1: view

Transcripts for PEBP1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for PEBP1 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PEBP1

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP1 Gene

No ASD Table

Relevant External Links for PEBP1 Gene

GeneLoc Exon Structure for
PEBP1

Expression for PEBP1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PEBP1 Gene

mRNA expression in normal human tissues for PEBP1 Gene
mRNA expression by BioGPS for PEBP1 GenemRNA expression by GTEx for PEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for PEBP1 Gene

This gene is overexpressed in Liver, secretome (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PEBP1 Gene



Protein tissue co-expression partners for PEBP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PEBP1

SOURCE GeneReport for Unigene cluster for PEBP1 Gene:

Hs.433863

Evidence on tissue expression from TISSUES for PEBP1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Pancreas(4.6)
  • Skin(4.1)
  • Eye(3.9)
  • Adrenal gland(3.2)
  • Intestine(3.2)
  • Kidney(3.1)
  • Muscle(2.8)
  • Lymph node(2.6)
  • Heart(2.5)
  • Thyroid gland(2.5)
  • Stomach(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PEBP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEBP1 Gene

Orthologs for PEBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PEBP1 31 30
  • 99.47 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia PEBP1 31 30
  • 89.84 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia PEBP1 31 30
  • 89.13 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Pebp1 17 31 30
  • 86.1 (n)
Pbp2 31
  • 84 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Pebp1 30
  • 83.42 (n)
oppossum
(Monodelphis domestica)
 Mammalia PEBP1 31
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)