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Aliases for PEBP1 Gene

Aliases for PEBP1 Gene

  • Phosphatidylethanolamine Binding Protein 1 2 3 5
  • Hippocampal Cholinergic Neurostimulating Peptide 2 3
  • Raf Kinase Inhibitory Protein 2 3
  • Raf Kinase Inhibitor Protein 3 4
  • Prostatic Binding Protein 2 3
  • Neuropolypeptide H3 3 4
  • HCNPpp 3 4
  • PEBP-1 3 4
  • PEBP 3 4
  • RKIP 3 4
  • PBP 3 4
  • Phosphatidylethanolamine-Binding Protein 1 3
  • Epididymis Secretory Protein Li 34 3
  • Epididymis Secretory Protein Li 96 3
  • Epididymis Luminal Protein 210 3
  • Prostatic-Binding Protein 4
  • HEL-S-34 3
  • HEL-S-96 3
  • HEL-210 3
  • HCNP 3

External Ids for PEBP1 Gene

Previous HGNC Symbols for PEBP1 Gene

  • PBP

Previous GeneCards Identifiers for PEBP1 Gene

  • GC12P117058
  • GC12P118573
  • GC12P115583

Summaries for PEBP1 Gene

Entrez Gene Summary for PEBP1 Gene

  • This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

GeneCards Summary for PEBP1 Gene

PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Gastric Cardia Adenocarcinoma and Lung Squamous Cell Carcinoma. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is PEBP4.

UniProtKB/Swiss-Prot for PEBP1 Gene

  • Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.

  • HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Wiki entry for PEBP1 Gene

Additional gene information for PEBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEBP1 Gene

Genomics for PEBP1 Gene

GeneHancer (GH) Regulatory Elements for PEBP1 Gene

Promoters and enhancers for PEBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I118134 Promoter/Enhancer 1.6 EPDnew ENCODE 556.6 +1.6 1588 5.3 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 VSIG10 PEBP1 LOC101928274 RFC5 WSB2 SUDS3 GC12M118176
GH12I118370 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.4 +238.4 238445 8.4 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SUDS3 TAOK3 ENSG00000270482 RFC5 PEBP1
GH12I118355 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.4 +221.9 221852 5.3 HDGF PKNOX1 CLOCK SMAD1 ARNT FEZF1 YY1 ZNF766 ZNF213 E2F8 TAOK3 SUDS3 PEBP1 RPS2P5
GH12I118236 Enhancer 0.9 Ensembl ENCODE 9.4 +102.1 102083 2.8 PKNOX1 BACH1 EBF1 BMI1 IRF4 GATA3 ATF7 BCLAF1 IKZF2 RUNX3 PEBP1 SUDS3 RPS2P5 GC12P118191 TAOK3
GH12I118328 Enhancer 1.3 Ensembl ENCODE dbSUPER 6 +194.8 194756 3.4 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ARID2 NCOA1 MBD2 MEF2D SUDS3 TAOK3 PEBP1 RPS2P5 GC12P118191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PEBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PEBP1 gene promoter:

Genomic Locations for PEBP1 Gene

Genomic Locations for PEBP1 Gene
chr12:118,135,858-118,145,585
(GRCh38/hg38)
Size:
9,728 bases
Orientation:
Plus strand
chr12:118,573,663-118,583,390
(GRCh37/hg19)

Genomic View for PEBP1 Gene

Genes around PEBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEBP1 Gene

Proteins for PEBP1 Gene

  • Protein details for PEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30086-PEBP1_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 1
    Protein Accession:
    P30086
    Secondary Accessions:
    • B2R4S1

    Protein attributes for PEBP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21057 Da
    Quaternary structure:
    • Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues Ser-338, Ser-339, Tyr-340 and Tyr-341. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for PEBP1 Gene

neXtProt entry for PEBP1 Gene

Post-translational modifications for PEBP1 Gene

  • Ubiquitination at isoforms=7, Lys47, isoforms=113, and isoforms=132

Other Protein References for PEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PEBP1 (RKIP)
  • Abcam antibodies for PEBP1

No data available for DME Specific Peptides for PEBP1 Gene

Domains & Families for PEBP1 Gene

Gene Families for PEBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PEBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P30086

UniProtKB/Swiss-Prot:

PEBP1_HUMAN :
  • Belongs to the phosphatidylethanolamine-binding protein family.
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP1: view

Function for PEBP1 Gene

Molecular function for PEBP1 Gene

UniProtKB/Swiss-Prot Function:
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
UniProtKB/Swiss-Prot Function:
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Ontology (GO) - Molecular Function for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA,HDA 22658674
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 17097642
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PEBP1: view
genes like me logo Genes that share phenotypes with PEBP1: view

Clone Products

  • Addgene plasmids for PEBP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP1 Gene

Localization for PEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with PEBP1: view

Pathways & Interactions for PEBP1 Gene

SuperPathways for PEBP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Signaling by moderate kinase activity BRAF mutants
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with PEBP1: view

Pathways by source for PEBP1 Gene

1 Cell Signaling Technology pathway for PEBP1 Gene

SIGNOR curated interactions for PEBP1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PEBP1: view

Drugs & Compounds for PEBP1 Gene

(8) Drugs for PEBP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202

(12) Additional Compounds for PEBP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-eicosenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/20:1)
  • GPCho(16:0/20:1n9)
  • GPCho(16:0/20:1w9)
  • GPCho(36:1)
88542-95-4
genes like me logo Genes that share compounds with PEBP1: view

Transcripts for PEBP1 Gene

mRNA/cDNA for PEBP1 Gene

Unigene Clusters for PEBP1 Gene

Phosphatidylethanolamine binding protein 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for PEBP1

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP1 Gene

No ASD Table

Relevant External Links for PEBP1 Gene

GeneLoc Exon Structure for
PEBP1
ECgene alternative splicing isoforms for
PEBP1

Expression for PEBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for PEBP1 Gene

This gene is overexpressed in Liver, secretome (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PEBP1 Gene



Protein tissue co-expression partners for PEBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PEBP1 Gene:

PEBP1

SOURCE GeneReport for Unigene cluster for PEBP1 Gene:

Hs.433863

Evidence on tissue expression from TISSUES for PEBP1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Pancreas(4.6)
  • Skin(4.1)
  • Eye(3.9)
  • Adrenal gland(3.2)
  • Intestine(3.2)
  • Kidney(3.1)
  • Muscle(2.8)
  • Lymph node(2.7)
  • Heart(2.5)
  • Thyroid gland(2.5)
  • Stomach(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PEBP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEBP1 Gene

Orthologs for PEBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEBP1 33 34
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia PEBP1 33 34
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia PEBP1 33 34
  • 89.13 (n)
mouse
(Mus musculus)
Mammalia Pebp1 33 16 34
  • 86.1 (n)
Pbp2 34
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pebp1 33
  • 83.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PEBP1 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PEBP1 33 34
  • 75.76 (n)
lizard
(Anolis carolinensis)
Reptilia PEBP1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pebp1 33
  • 71.53 (n)
zebrafish
(Danio rerio)
Actinopterygii pebp1 33 34
  • 68.98 (n)
zgc56033 33
fruit fly
(Drosophila melanogaster)
Insecta CG10298 33 34
  • 59.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012962 33
  • 58.49 (n)
worm
(Caenorhabditis elegans)
Secernentea F40A3.3 34
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7271 34
  • 48 (a)
OneToOne
Species where no ortholog for PEBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEBP1 Gene

ENSEMBL:
Gene Tree for PEBP1 (if available)
TreeFam:
Gene Tree for PEBP1 (if available)

Paralogs for PEBP1 Gene

Paralogs for PEBP1 Gene

(2) SIMAP similar genes for PEBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PEBP1 Gene

genes like me logo Genes that share paralogs with PEBP1: view

Variants for PEBP1 Gene

Sequence variations from dbSNP and Humsavar for PEBP1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015970 -- 118,141,419(+) T/G intron_variant
rs1000324106 -- 118,144,189(+) G/T intron_variant
rs1000559345 -- 118,137,227(+) C/T intron_variant
rs1000705292 -- 118,142,696(+) C/T intron_variant
rs1000837065 -- 118,141,763(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PEBP1 Gene

Variant ID Type Subtype PubMed ID
esv3581916 CNV gain 25503493

Variation tolerance for PEBP1 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEBP1 Gene

Human Gene Mutation Database (HGMD)
PEBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEBP1 Gene

Disorders for PEBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PEBP1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search PEBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PEBP1

genes like me logo Genes that share disorders with PEBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEBP1 Gene

Publications for PEBP1 Gene

  1. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. (PMID: 9782050) Banfield MJ … Brady RL (Structure (London, England : 1993) 1998) 3 4 22 58
  2. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. (PMID: 7637590) Tohdoh N … Ojika K (Brain research. Molecular brain research 1995) 3 4 22 58
  3. A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein. (PMID: 8144042) Hori N … Matsubara K (Gene 1994) 3 4 22 58
  4. Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. (PMID: 7807553) Seddiqi N … Schoentgen F (Journal of molecular evolution 1994) 3 4 22 58
  5. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. (PMID: 21831839) Zhao J … Wenzel SE (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58

Products for PEBP1 Gene