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This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Myeloid Sarcoma and Lung Cancer. Among its related pathways are Signaling by GPCR and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is MRPL38.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 17097642 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
3 | Developmental Biology |
.51
|
|
4 | Cytokine Signaling in Immune system | ||
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0010466 | negative regulation of peptidase activity | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
GO:0043409 | negative regulation of MAPK cascade | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 271 | ||
Omega-3-carboxylic acids | Approved, Investigational | Pharma | Carrier, binder | 0 | ||
Methicillin Acyl-Serine | Experimental | Pharma | Target | 0 | ||
Nitrocefin Acyl-Serine | Experimental | Pharma | Target | 0 | ||
Penicillin G Acyl-Serine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
CE(22:0) |
|
61510-09-6 |
|
|||
Hydroxyclomipramine |
|
97859-69-3 | ||||
LysoPE(P-16:0/0:0) |
|
174062-72-7 | ||||
PC(18:1(9Z)e/2:0) |
|
|
||||
PC(20:2(11Z,14Z)/18:1(11Z)) |
|
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pebp1 30 17 31 |
|
OneToMany | |
Pbp2 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Pebp1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PEBP1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | PEBP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PEBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pebp1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pebp1 30 31 |
|
OneToOne | |
zgc56033 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10298 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012962 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | F40A3.3 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7271 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1050625 | Benign: not provided | 118,144,672(+) |
C/T NM_002567.4(PEBP1):c.433C>T (p.His145Tyr) |
MISSENSE | |
rs55716409 | Benign: not provided | 118,139,489(+) |
A/G NM_002567.4(PEBP1):c.284A>G (p.Asn95Ser) |
MISSENSE | |
VAR_006048 | - |
p.Ser9Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3581916 | CNV | gain | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myeloid sarcoma |
|
|
lung cancer |
|
|
alzheimer disease |
|
|
prostate cancer |
|
|
griscelli syndrome, type 3 |
|
|