Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide ... See more...
Aliases for PEBP1 Gene
Aliases for PEBP1 Gene
- Phosphatidylethanolamine Binding Protein 1 2 3 5
- PEBP 2 3 4
- RKIP 2 3 4
- Hippocampal Cholinergic Neurostimulating Peptide 2 3
- Phosphatidylethanolamine-Binding Protein 1 3 4
- Raf Kinase Inhibitory Protein 2 3
- Raf Kinase Inhibitor Protein 3 4
- Prostatic Binding Protein 2 3
- Neuropolypeptide H3 3 4
- HCNPpp 3 4
External Ids for PEBP1 Gene
- HGNC: 8630
- NCBI Entrez Gene: 5037
- Ensembl: ENSG00000089220
- OMIM®: 604591
- UniProtKB/Swiss-Prot: P30086
Previous HGNC Symbols for PEBP1 Gene
- PBP
Previous GeneCards Identifiers for PEBP1 Gene
- GC12P117058
- GC12P118573
- GC12P115583
Summaries for PEBP1 Gene
-
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
GeneCards Summary for PEBP1 Gene
PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Myeloid Sarcoma and Lung Cancer. Among its related pathways are Signaling by GPCR and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is MRPL38.
UniProtKB/Swiss-Prot Summary for PEBP1 Gene
-
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
-
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
Additional gene information for PEBP1 Gene
- HGNC (8630)
- NCBI Entrez Gene (5037)
- Ensembl (ENSG00000089220)
- OMIM® (604591)
- UniProtKB/Swiss-Prot (P30086)
- Open Targets Platform(ENSG00000089220)
- Search for PEBP1 at DataMed
- Search for PEBP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PEBP1 Gene
Genomics for PEBP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PEBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PEBP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PEBP1
- Top Transcription factor binding sites by QIAGEN in the PEBP1 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for PEBP1 Gene
Latest Assembly
- chr12:118,136,124-118,145,584
- (GRCh38/hg38)
- Size:
- 9,461 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:118,573,929-118,583,389
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,461 bases
- Orientation:
- Plus strand
- chr12:118,573,663-118,583,389
- (GRCh37/hg19 by Ensembl)
- Size:
- 9,727 bases
- Orientation:
- Plus strand
Genomic View for PEBP1 Gene
Genes around PEBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.23 by HGNC
- 12q24.23 by Entrez Gene
- 12q24.23 by Ensembl
PEBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PEBP1 Gene
Proteins for PEBP1 Gene
-
Protein details for PEBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30086-PEBP1_HUMAN
- Recommended name:
- Phosphatidylethanolamine-binding protein 1
- Protein Accession:
- P30086
- B2R4S1
Protein attributes for PEBP1 Gene
- Size:
- 187 amino acids
- Molecular mass:
- 21057 Da
- Quaternary structure:
-
- Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
Protein Expression for PEBP1 Gene
Post-translational modifications for PEBP1 Gene
Other Protein References for PEBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PEBP1 / RKIP Antibody and PEBP1 / RKIP Monoclonal Antibody
- NSJ Bioreagents RKIP Antibody / PEBP1 / PBP
-
Custom Antibody ServicesOriGene Antibodies for PEBP1
- Novus Biologicals Antibodies for PEBP1
- Invitrogen Antibodies for PEBP1 (AFLGC-PEBP1)
-
Custom Antibody ServicesProSci Antibodies for PEBP1
- phosphatidylethanolamine binding protein 1 [13-207]
- phosphatidylethanolamine binding protein 1 [13-208]
- phosphatidylethanolamine binding protein 1 [30-381]
- phosphatidylethanolamine binding protein 1 [46-161]
- phosphatidylethanolamine binding protein 1 [46-162]
- phosphatidylethanolamine binding protein 1 [70-481]
- Phosphatidylethanolamine-binding protein 1 [63-392]
-
Santa Cruz Biotechnology (SCBT) Antibodies for PEBP1
- Sino Biological Antibodies for PEBP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PEBP1
- Origene Custom Protein Services for PEBP1
- Sino Biological Recombinant Proteins for PEBP1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PEBP1
-
Abcam proteins for PEBP1
Assay products for research
- antibodies-online: Show 37 available PEBP1 Elisa Kits ranked by validation data
- Compare Top PEBP1 Elisa Kits
-
Quality Products:
- ABIN422116
- ABIN1571806
- ABIN5522692
- ABIN847257
- ABIN5593337
- ABIN771080
- ABIN5657756
- ABIN2537781
- ABIN2950295
- ABIN4971942
- ABIN429461
- ABIN2851441
- ABIN773625
- ABIN5657757
- ABIN2537782
- ABIN4971943
- ABIN6212008
- ABIN2044209
- ABIN1147752
- ABIN436251
- ABIN772287
- ABIN5657758
- ABIN6212009
- ABIN6212010
- ABIN1147754
- ABIN995049
- ABIN1147749
-
Boster Bio ELISA Kits for PEBP1
No data available for DME Specific Peptides for PEBP1 Gene
Domains & Families for PEBP1 Gene
Gene Families for PEBP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PEBP1 Gene
- InterPro:
- Blocks:
-
- Phosphatidylethanolamine-binding protein
- ProtoNet:
Suggested Antigen Peptide Sequences for PEBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51535, highly similar to Phosphatidylethanolamine-binding protein 1 (B4DRT4_HUMAN)
- Raf kinase inhibitor protein (PEBP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30086- Family:
-
- Belongs to the phosphatidylethanolamine-binding protein family.
Function for PEBP1 Gene
Molecular function for PEBP1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
- UniProtKB/Swiss-Prot Function:
- HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
Phenotypes From GWAS Catalog for PEBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 17097642 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for PEBP1 Gene
- MGI mutant phenotypes for PEBP1:
-
inferred from 3 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for PEBP1:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PEBP1 - Starting at $85 >
- * PEBP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PEBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PEBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PEBP1
miRNA for PEBP1 Gene
- miRTarBase miRNAs that target PEBP1
-
- hsa-miR-224-5p (MIRT007008)
- hsa-miR-375 (MIRT019828)
- hsa-miR-155-5p (MIRT020686)
- hsa-miR-222-3p (MIRT046731)
- hsa-miR-92a-3p (MIRT049454)
- hsa-miR-181a-5p (MIRT133211)
- hsa-miR-181b-5p (MIRT133212)
- hsa-miR-181c-5p (MIRT133213)
- hsa-miR-181d-5p (MIRT133215)
- hsa-miR-340-5p (MIRT231688)
- hsa-miR-759 (MIRT231689)
- hsa-miR-3174 (MIRT231690)
- hsa-miR-5586-3p (MIRT231691)
- hsa-miR-539-5p (MIRT335358)
- hsa-miR-4753-5p (MIRT373989)
- hsa-miR-4755-3p (MIRT373990)
- hsa-miR-6768-3p (MIRT373993)
- hsa-miR-4765 (MIRT490993)
- hsa-miR-1236-5p (MIRT490994)
- hsa-miR-5590-3p (MIRT490995)
- hsa-miR-142-5p (MIRT490996)
- hsa-miR-551b-5p (MIRT490997)
- hsa-miR-4484 (MIRT490998)
- hsa-miR-548an (MIRT490999)
- hsa-miR-4282 (MIRT491000)
- hsa-miR-4685-3p (MIRT700899)
- hsa-miR-4287 (MIRT700900)
- hsa-miR-6875-3p (MIRT711629)
- hsa-miR-103a-2-5p (MIRT711630)
- hsa-miR-4778-3p (MIRT711631)
- hsa-miR-1976 (MIRT711632)
- hsa-miR-4469 (MIRT711633)
- hsa-miR-6893-3p (MIRT711634)
- hsa-miR-370-3p (MIRT711635)
- hsa-miR-660-3p (MIRT711636)
- hsa-miR-4667-3p (MIRT711637)
- hsa-miR-1470 (MIRT711638)
- hsa-miR-665 (MIRT711639)
- hsa-miR-27a-5p (MIRT734635)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PEBP1
- Browse OriGene Inhibitory RNA Products For PEBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PEBP1
Clone products for research
- Applied Biological Materials (abm): Clones for PEBP1 - Starting at $45 >
- * PEBP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PEBP1
- Addgene plasmids for PEBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PEBP1
Cell Lines for research
-
Horizon Cell Lines for PEBP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP1 Gene
Localization for PEBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PEBP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for PEBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for PEBP1 Gene
3 BioSystems pathways for PEBP1 Gene
56 Reactome pathways for PEBP1 Gene
1 Qiagen pathway for PEBP1 Gene
- Phospholipase-C Pathway
1 Cell Signaling Technology pathway for PEBP1 Gene
Interacting Proteins for PEBP1 Gene
Selected Interacting proteins:
P30086-PEBP1_HUMAN
ENSP00000261313
for PEBP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PEBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
| GO:0043409 | negative regulation of MAPK cascade | IBA | 21873635 |
Drugs & Compounds for PEBP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 271 | ||
| Omega-3-carboxylic acids | Approved, Investigational | Pharma | Carrier, binder | 0 | ||
| Methicillin Acyl-Serine | Experimental | Pharma | Target | 0 | ||
| Nitrocefin Acyl-Serine | Experimental | Pharma | Target | 0 | ||
| Penicillin G Acyl-Serine | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CE(22:0) |
|
61510-09-6 |
|
|||
| Hydroxyclomipramine |
|
97859-69-3 | ||||
| LysoPE(P-16:0/0:0) |
|
174062-72-7 | ||||
| PC(18:1(9Z)e/2:0) |
|
|
||||
| PC(20:2(11Z,14Z)/18:1(11Z)) |
|
|
Transcripts for PEBP1 Gene
mRNA/cDNA for PEBP1 Gene
- 1 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261313 1431 nts (view in UCSC)
- ENST00000542939 708 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PEBP1 - Starting at $85 >
- * PEBP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PEBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PEBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PEBP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PEBP1
- Browse OriGene Inhibitory RNA Products For PEBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PEBP1
Clone products for research
- Applied Biological Materials (abm): Clones for PEBP1 - Starting at $45 >
- * PEBP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PEBP1
- Addgene plasmids for PEBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PEBP1
Relevant External Links for PEBP1 Gene
- GeneLoc Exon Structure for
- PEBP1
Expression for PEBP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
- Islets of Langerhans
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Amnion (Extraembryonic Tissues)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PEBP1 Gene
This gene is overexpressed in Adrenal Gland (x4.2).
This gene is overexpressed in Liver, secretome (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PEBP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PEBP1
SOURCE GeneReport for Unigene cluster for PEBP1 Gene:
Hs.433863Evidence on tissue expression from TISSUES for PEBP1 Gene
- Nervous system(5)
- Lung(4.9)
- Liver(4.8)
- Pancreas(4.7)
- Skin(4.3)
- Eye(4.1)
- Kidney(3.5)
- Heart(3.4)
- Intestine(3.4)
- Adrenal gland(3.4)
- Muscle(3.1)
- Thyroid gland(3)
- Lymph node(2.8)
- Stomach(2.6)
- Spleen(2.4)
- Blood(2.4)
- Bone marrow(2.3)
Primer products for research
-
OriGene qPCR primer pairs for PEBP1
-
OriGene qPCR primer pairs and template standards for PEBP1
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEBP1 Gene
Orthologs for PEBP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PEBP1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pebp1 30 17 31 |
|
OneToMany | |
| Pbp2 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Pebp1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PEBP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | PEBP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PEBP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pebp1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pebp1 30 31 |
|
OneToOne | |
| zgc56033 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10298 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012962 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F40A3.3 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7271 31 |
|
OneToOne |
- Species where no ortholog for PEBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PEBP1 Gene
- ENSEMBL:
- Gene Tree for PEBP1 (if available)
- TreeFam:
- Gene Tree for PEBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PEBP1: view image
Paralogs for PEBP1 Gene
Pseudogenes.org Pseudogenes for PEBP1 Gene
Variants for PEBP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PEBP1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1050625 | Benign: not provided | 118,144,672(+) |
C/T NM_002567.4(PEBP1):c.433C>T (p.His145Tyr) |
MISSENSE | |
| rs55716409 | Benign: not provided | 118,139,489(+) |
A/G NM_002567.4(PEBP1):c.284A>G (p.Asn95Ser) |
MISSENSE | |
| VAR_006048 | - |
p.Ser9Asn |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3581916 | CNV | gain | 25503493 |
Residual Variation Intolerance Score:
45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.12;
38.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PEBP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEBP1 Gene
Disorders for PEBP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloid sarcoma |
|
|
| lung cancer |
|
|
| alzheimer disease |
|
|
| prostate cancer |
|
|
| griscelli syndrome, type 3 |
|
|
Search PEBP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PEBP1
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PEBP1 Gene
Publications for PEBP1 Gene
- Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. (PMID: 9782050) Banfield MJ … Brady RL (Structure (London, England : 1993) 1998) 3 4 23
- Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. (PMID: 7637590) Tohdoh N … Ojika K (Brain research. Molecular brain research 1995) 3 4 23
- A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein. (PMID: 8144042) Hori N … Matsubara K (Gene 1994) 3 4 23
- Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. (PMID: 7807553) Seddiqi N … Schoentgen F (Journal of molecular evolution 1994) 3 4 23
- 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. (PMID: 21831839) Zhao J … Wenzel SE (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
ExternalLinks
Products for PEBP1 Gene
- Custom Antibody ServicesOriGene Antibodies for PEBP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PEBP1
- Origene Custom Protein Services for PEBP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PEBP1
- Browse OriGene Inhibitory RNA Products For PEBP1
- OriGene qPCR primer pairs for PEBP1
- OriGene qPCR primer pairs and template standards for PEBP1
- OriGene CRISPR knockouts for PEBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PEBP1
- Sino Biological Human cDNA Clone for PEBP1
- Sino Biological Recombinant Proteins for PEBP1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PEBP1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PEBP1
- Novus Biologicals proteins and lysates for PEBP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PEBP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for PEBP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PEBP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PEBP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PEBP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PEBP1
- Addgene plasmids for PEBP1
- antibodies-online: Show 53 available PEBP1 Antibodies ranked by validation data
- Compare Top PEBP1 Antibodies
- antibodies-online: Show 37 available PEBP1 Elisa Kits ranked by validation data
- Compare Top PEBP1 Elisa Kits
- Quality Products:
- ABIN422116
- ABIN1571806
- ABIN5522692
- ABIN847257
- ABIN5593337
- ABIN771080
- ABIN5657756
- ABIN2537781
- ABIN2950295
- ABIN4971942
- ABIN429461
- ABIN2851441
- ABIN773625
- ABIN5657757
- ABIN2537782
- ABIN4971943
- ABIN6212008
- ABIN2044209
- ABIN1147752
- ABIN436251
- ABIN772287
- ABIN5657758
- ABIN6212009
- ABIN6212010
- ABIN1147754
- ABIN995049
- ABIN1147749
- antibodies-online: Show 20 available PEBP1 Proteins ranked by validation data
- Compare Top PEBP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PEBP1
- Search Santa Cruz Biotechnology (SCBT) for PEBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PEBP1
- Custom Antibody ServicesProSci Antibodies for PEBP1
- phosphatidylethanolamine binding protein 1 [13-207]
- phosphatidylethanolamine binding protein 1 [13-208]
- phosphatidylethanolamine binding protein 1 [30-381]
- phosphatidylethanolamine binding protein 1 [46-161]
- phosphatidylethanolamine binding protein 1 [46-162]
- phosphatidylethanolamine binding protein 1 [70-481]
- Phosphatidylethanolamine-binding protein 1 [63-392]
- Search for PEBP1 Proteins at ProSci
- Horizon Cell Lines for PEBP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PEBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PEBP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PEBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PEBP1
Sources for PEBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB