Aliases for PEAK3 Gene

Aliases for PEAK3 Gene

  • PEAK Family Member 3 2 3 5
  • Protein PEAK3 3 4
  • C19orf35 3 4
  • Chromosome 19 Open Reading Frame 35 2
  • FLJ45778 2
  • PEAK3 5

External Ids for PEAK3 Gene

Previous HGNC Symbols for PEAK3 Gene

  • C19orf35

Summaries for PEAK3 Gene

GeneCards Summary for PEAK3 Gene

PEAK3 (PEAK Family Member 3) is a Protein Coding gene. Diseases associated with PEAK3 include Pulmonary Embolism And Infarction and Mandibulofacial Dysostosis With Alopecia. An important paralog of this gene is PEAK1.

UniProtKB/Swiss-Prot Summary for PEAK3 Gene

  • Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869).

Additional gene information for PEAK3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PEAK3 Gene

Genomics for PEAK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PEAK3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002281 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 600.7 -0.1 -126 1.8 ZIC2 PKNOX1 REST IKZF2 BRD9 EZH2 HDAC1 ZNF341 EED SP2 PEAK3 lnc-LINGO3-1 ENSG00000273734 LINGO3
GH19J002280 Enhancer 0.6 dbSUPER 600.7 +1.1 1087 0.5 ZIC2 BRD9 SCRT2 SCRT1 BCOR ZNF768 ADNP KDM1A ZFP36 NFXL1 PEAK3 lnc-JSRP1-2 ENSG00000273734 JSRP1
GH19J002038 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 +231.2 231150 24.2 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A ZBTB33 ATF7 PRDM10 ZNF629 MKNK2 ZNF77 SF3A2 CIRBP DAZAP1 TCF3 LMNB2 ZNF555 DOT1L LOC100288123
GH19J002287 Promoter/Enhancer 1.2 FANTOM5 Ensembl dbSUPER 21.2 -5.9 -5889 0.7 GATAD2A RXRB HDAC2 FOXA2 ZBTB17 ZNF205 KDM6A BCOR SAP130 ZGPAT lnc-LINGO3-1 PEAK3 CSNK1G2 MOB3A MKNK2 KLF16 DOT1L OAZ1 MN297549 ENSG00000273734
GH19J002079 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 +193.3 193267 19 ZNF221 SP1 HNRNPL GATAD2A CTCF ATF7 ZNF629 TFE3 ZNF512 RFX1 MOB3A IZUMO4 CIRBP ZNF77 LMNB2 ZNF555 BTBD2 SF3A2 TLE2 MKNK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PEAK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PEAK3

Genomic Locations for PEAK3 Gene

Genomic Locations for PEAK3 Gene
7,545 bases
Minus strand
7,551 bases
Minus strand

Genomic View for PEAK3 Gene

Genes around PEAK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEAK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEAK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEAK3 Gene

Proteins for PEAK3 Gene

  • Protein details for PEAK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein PEAK3
    Protein Accession:

    Protein attributes for PEAK3 Gene

    473 amino acids
    Molecular mass:
    50509 Da
    Quaternary structure:
    • Homodimerizes (PubMed:31311869). Interacts with CRK isoform CRK-II; the interaction requires PEAK3 homodimerization (PubMed:31311869).

neXtProt entry for PEAK3 Gene

Post-translational modifications for PEAK3 Gene

No Post-translational modifications

Other Protein References for PEAK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PEAK3 Gene

Domains & Families for PEAK3 Gene

Gene Families for PEAK3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PEAK3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily.
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with PEAK3: view

No data available for Suggested Antigen Peptide Sequences for PEAK3 Gene

Function for PEAK3 Gene

Molecular function for PEAK3 Gene

UniProtKB/Swiss-Prot Function:
Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869).

Phenotypes From GWAS Catalog for PEAK3 Gene

Gene Ontology (GO) - Molecular Function for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA 21873635
GO:0005515 protein binding IPI 31311869
GO:0043621 protein self-association IDA 31311869
genes like me logo Genes that share ontologies with PEAK3: view
genes like me logo Genes that share phenotypes with PEAK3: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEAK3 Gene

Localization for PEAK3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEAK3 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IBA 21873635
GO:0015629 actin cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with PEAK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PEAK3 Gene

Pathways & Interactions for PEAK3 Gene

PathCards logo

SuperPathways for PEAK3 Gene

No Data Available

Interacting Proteins for PEAK3 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000345102 for PEAK3 Gene via STRING

Gene Ontology (GO) - Biological Process for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA 21873635
GO:0008360 regulation of cell shape IMP 31311869
GO:0032956 regulation of actin cytoskeleton organization IMP 31311869
genes like me logo Genes that share ontologies with PEAK3: view

No data available for Pathways by source and SIGNOR curated interactions for PEAK3 Gene

Drugs & Compounds for PEAK3 Gene

No Compound Related Data Available

Transcripts for PEAK3 Gene

mRNA/cDNA for PEAK3 Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PEAK3 Gene

No ASD Table

Relevant External Links for PEAK3 Gene

GeneLoc Exon Structure for

Expression for PEAK3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PEAK3

Evidence on tissue expression from TISSUES for PEAK3 Gene

  • Blood(4.5)
  • Skin(2.4)
  • Nervous system(2.4)
  • Liver(2.2)
  • Lung(2.2)
  • Kidney(2)
  • Intestine(2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEAK3 Gene

Orthologs for PEAK3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PEAK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C19orf35 31
  • 99 (a)
C19H19orf35 30
  • 98.6 (n)
(Bos Taurus)
Mammalia C7H19orf35 30
  • 78.55 (n)
C19orf35 31
  • 70 (a)
(Canis familiaris)
Mammalia C20H19orf35 30
  • 78.3 (n)
C19orf35 31
  • 68 (a)
(Monodelphis domestica)
Mammalia C19orf35 31
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia C19orf35 31
  • 43 (a)
Species where no ortholog for PEAK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PEAK3 Gene

Gene Tree for PEAK3 (if available)
Gene Tree for PEAK3 (if available)

Paralogs for PEAK3 Gene

Paralogs for PEAK3 Gene

genes like me logo Genes that share paralogs with PEAK3: view

Variants for PEAK3 Gene

Additional dbSNP identifiers (rs#s) for PEAK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PEAK3 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv2717882 CNV deletion 23290073
nsv578383 CNV loss 21841781
nsv833707 CNV loss 17160897

Variation tolerance for PEAK3 Gene

Gene Damage Index Score: 8.19; 84.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEAK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PEAK3 Gene

Disorders for PEAK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PEAK3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search PEAK3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PEAK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEAK3 Gene

Publications for PEAK3 Gene

  1. PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. (PMID: 31311869) Lopez ML … Jura N (Proceedings of the National Academy of Sciences of the United States of America 2019) 2 3 4
  2. SHEDding light on the role of Pragmin pseudo-kinases in cancer. (PMID: 30906642) Roche S … Labesse G (American journal of cancer research 2019) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. (PMID: 29503074) Lecointre C … Roche S (Structure (London, England : 1993) 2018) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PEAK3 Gene

Sources for PEAK3 Gene