Aliases for PEAK1 Gene
External Ids for PEAK1 Gene
Previous GeneCards Identifiers for PEAK1 Gene
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
GeneCards Summary for PEAK1 Gene
PEAK1 (Pseudopodium Enriched Atypical Kinase 1) is a Protein Coding gene. Diseases associated with PEAK1 include Retinitis Pigmentosa 18 and Retinitis Pigmentosa. Among its related pathways are Tyrosine Kinases / Adaptors. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is PRAG1.
UniProtKB/Swiss-Prot Summary for PEAK1 Gene
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654).