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Aliases for PEA15 Gene

Aliases for PEA15 Gene

  • Proliferation And Apoptosis Adaptor Protein 15 2 3 5
  • Phosphoprotein Enriched In Diabetes 2 3 4
  • 15 KDa Phosphoprotein Enriched In Astrocytes 3 4
  • Phosphoprotein Enriched In Astrocytes 15 2 3
  • Proliferation And Apoptosis Adaptor 15 2 3
  • Homolog Of Mouse MAT-1 Oncogene 2 3
  • PED 3 4
  • Mammary Transforming Gene 1, Mouse, Homolog Of 3
  • Phosphoprotein Enriched In Astrocytes, 15kD 2
  • Astrocytic Phosphoprotein PEA-15 3
  • PED-PEA15 3
  • PED/PEA15 3
  • HUMMAT1H 3
  • PEA-15 3
  • HMAT1 3
  • MAT1H 3
  • MAT1 3

External Ids for PEA15 Gene

Previous GeneCards Identifiers for PEA15 Gene

  • GC01P157967
  • GC01P155907
  • GC01P156952
  • GC01P157391
  • GC01P156990
  • GC01P158441
  • GC01P160175
  • GC01P131531

Summaries for PEA15 Gene

Entrez Gene Summary for PEA15 Gene

  • This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for PEA15 Gene

PEA15 (Proliferation And Apoptosis Adaptor Protein 15) is a Protein Coding gene. Among its related pathways are RET signaling and Apoptosis Modulation and Signaling.

UniProtKB/Swiss-Prot for PEA15 Gene

  • Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Gene Wiki entry for PEA15 Gene

Additional gene information for PEA15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEA15 Gene

Genomics for PEA15 Gene

GeneHancer (GH) Regulatory Elements for PEA15 Gene

Promoters and enhancers for PEA15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I160203 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.5 2455 7.6 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 POLR2B PEA15 LOC729867 NCSTN DCAF8 LOC100287049 IGSF8 PIGM COPA
GH01I160095 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -105.8 -105771 8.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IGSF8 ATP1A4 CASQ1 KCNJ10 PEA15 DCAF8 PEX19 PIGM ENSG00000225279 ATP1A2
GH01I160123 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.6 -78.9 -78898 6.8 PKNOX1 CLOCK FOXA2 SIN3A FOS NFIL3 ATF4 MAFF GLIS1 RCOR2 GC01P160125 GC01P160126 ATP1A4 IGSF8 PEA15 CASQ1 KCNJ9 PIGM ATP1A2 GC01M160128
GH01I160250 Enhancer 0.9 ENCODE dbSUPER 10.9 +46.3 46326 2 CTCF FOXA2 SAP130 MAX CEBPG ZNF2 RAD21 RFX5 FOXK2 HSF1 CASQ1 PEA15 ATP1A2 IGSF8 DCAF8 GC01P160261 ENSG00000258465 PIR40871
GH01I160104 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.4 -100.7 -100662 1.3 ZNF121 SPI1 KCNJ9 CASQ1 PEA15 DCAF8 PEX19 PIGM ATP1A4 ENSG00000225279 KCNJ10 IGSF8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PEA15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PEA15 gene promoter:

Genomic Locations for PEA15 Gene

Genomic Locations for PEA15 Gene
chr1:160,205,319-160,215,376
(GRCh38/hg38)
Size:
10,058 bases
Orientation:
Plus strand
chr1:160,175,125-160,185,166
(GRCh37/hg19)

Genomic View for PEA15 Gene

Genes around PEA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEA15 Gene

Proteins for PEA15 Gene

  • Protein details for PEA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15121-PEA15_HUMAN
    Recommended name:
    Astrocytic phosphoprotein PEA-15
    Protein Accession:
    Q15121
    Secondary Accessions:
    • B1AKZ3
    • O00511

    Protein attributes for PEA15 Gene

    Size:
    130 amino acids
    Molecular mass:
    15040 Da
    Quaternary structure:
    • Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.

    Three dimensional structures from OCA and Proteopedia for PEA15 Gene

    Alternative splice isoforms for PEA15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEA15 Gene

Post-translational modifications for PEA15 Gene

  • Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.

Other Protein References for PEA15 Gene

No data available for DME Specific Peptides for PEA15 Gene

Domains & Families for PEA15 Gene

Gene Families for PEA15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PEA15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PEA15: view

No data available for UniProtKB/Swiss-Prot for PEA15 Gene

Function for PEA15 Gene

Molecular function for PEA15 Gene

GENATLAS Biochemistry:
major astrocyte phosphoprotein PEA-15,murine mammary transforming gene (MAT1) homolog,15kDa,overexpressed in some breast cancer lines,controlling glucose transport
UniProtKB/Swiss-Prot Function:
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Gene Ontology (GO) - Molecular Function for PEA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10442631
genes like me logo Genes that share ontologies with PEA15: view
genes like me logo Genes that share phenotypes with PEA15: view

Animal Models for PEA15 Gene

MGI Knock Outs for PEA15:

Animal Model Products

miRNA for PEA15 Gene

miRTarBase miRNAs that target PEA15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PEA15 Gene

Localization for PEA15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEA15 Gene

Cytoplasm. Note=Associated with microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEA15 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PEA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005875 microtubule associated complex NAS 8662970
genes like me logo Genes that share ontologies with PEA15: view

Pathways & Interactions for PEA15 Gene

SuperPathways for PEA15 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK-Erk Pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with PEA15: view

Pathways by source for PEA15 Gene

2 Sino Biological pathways for PEA15 Gene
3 Cell Signaling Technology pathways for PEA15 Gene
1 BioSystems pathway for PEA15 Gene

SIGNOR curated interactions for PEA15 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PEA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IEA --
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0006810 transport TAS 9670003
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PEA15: view

Drugs & Compounds for PEA15 Gene

(2) Drugs for PEA15 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(2) Additional Compounds for PEA15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PEA15: view

Transcripts for PEA15 Gene

Unigene Clusters for PEA15 Gene

Phosphoprotein enriched in astrocytes 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PEA15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8
SP1: -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8: - - - - - -

Relevant External Links for PEA15 Gene

GeneLoc Exon Structure for
PEA15
ECgene alternative splicing isoforms for
PEA15

Expression for PEA15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PEA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEA15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.6).

Protein differential expression in normal tissues from HIPED for PEA15 Gene

This gene is overexpressed in Brain (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PEA15 Gene



Protein tissue co-expression partners for PEA15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PEA15 Gene:

PEA15

SOURCE GeneReport for Unigene cluster for PEA15 Gene:

Hs.517216

mRNA Expression by UniProt/SwissProt for PEA15 Gene:

Q15121-PEA15_HUMAN
Tissue specificity: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.

Evidence on tissue expression from TISSUES for PEA15 Gene

  • Nervous system(5)
  • Skin(4.9)
  • Liver(4.8)
  • Heart(4.7)
  • Lung(4.6)
  • Pancreas(4.5)
  • Eye(4.3)
  • Intestine(3.9)
  • Kidney(3.6)
  • Blood(3.4)
  • Bone(3.1)
  • Muscle(2.6)
  • Spleen(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PEA15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PEA15 Gene

Orthologs for PEA15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PEA15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEA15 33 34
  • 99.74 (n)
rat
(Rattus norvegicus)
Mammalia Pea15 33
  • 96.15 (n)
oppossum
(Monodelphis domestica)
Mammalia PEA15 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEA15 33 34
  • 95.38 (n)
mouse
(Mus musculus)
Mammalia Pea15a 33 16 34
  • 94.87 (n)
dog
(Canis familiaris)
Mammalia PEA15 33 34
  • 90.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PEA15 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pea15 33
  • 73.15 (n)
zebrafish
(Danio rerio)
Actinopterygii PEA15 34
  • 78 (a)
OneToOne
LOC557745 33
  • 72.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4988 34
  • 31 (a)
OneToOne
Species where no ortholog for PEA15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PEA15 Gene

ENSEMBL:
Gene Tree for PEA15 (if available)
TreeFam:
Gene Tree for PEA15 (if available)

Paralogs for PEA15 Gene

Pseudogenes.org Pseudogenes for PEA15 Gene

genes like me logo Genes that share paralogs with PEA15: view

No data available for Paralogs for PEA15 Gene

Variants for PEA15 Gene

Sequence variations from dbSNP and Humsavar for PEA15 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028275 -- 160,210,603(+) C/A intron_variant
rs1000310062 -- 160,209,214(+) C/T intron_variant
rs1000318267 -- 160,203,718(+) G/A upstream_transcript_variant
rs1000381176 -- 160,215,409(+) T/C downstream_transcript_variant
rs1000418349 -- 160,203,435(+) C/T upstream_transcript_variant

Variation tolerance for PEA15 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PEA15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEA15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PEA15 Gene

Disorders for PEA15 Gene

Additional Disease Information for PEA15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PEA15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PEA15 Gene

Publications for PEA15 Gene

  1. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. (PMID: 10607908) Wolford JK … Prochazka M (Gene 2000) 3 4 44 58
  2. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. (PMID: 9670003) Condorelli G … Beguinot F (The EMBO journal 1998) 3 4 22 58
  3. The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. (PMID: 8662970) Estellés A … Chneiweiss H (The Journal of biological chemistry 1996) 3 4 22 58
  4. Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia. (PMID: 28216548) Sung JH … Koh PO (The Journal of veterinary medical science 2017) 2 3 58
  5. Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo. (PMID: 26317969) Kerbrat S … Le Gouvello S (PloS one 2015) 2 3 58

Products for PEA15 Gene

Sources for PEA15 Gene

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