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Aliases for PDZD11 Gene

Aliases for PDZD11 Gene

  • PDZ Domain Containing 11 2 3 5
  • Plasma Membrane Calcium ATPase-Interacting Single-PDZ Protein 3 4
  • PMCA-Interacting Single-PDZ Protein 3 4
  • ATPase-Interacting PDZ Protein 3 4
  • PDZK11 3 4
  • AIPP1 3 4
  • PISP 3 4
  • PDZ Domain-Containing Protein 11 3

External Ids for PDZD11 Gene

Previous HGNC Symbols for PDZD11 Gene

  • PDZK11

Previous GeneCards Identifiers for PDZD11 Gene

  • GC0XM069289
  • GC0XM068822
  • GC0XM069422
  • GC0XM069506
  • GC0XM063327

Summaries for PDZD11 Gene

GeneCards Summary for PDZD11 Gene

PDZD11 (PDZ Domain Containing 11) is a Protein Coding gene. Diseases associated with PDZD11 include Purulent Acute Otitis Media and Middle Ear Disease. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is WHRN.

Gene Wiki entry for PDZD11 Gene

Additional gene information for PDZD11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDZD11 Gene

Genomics for PDZD11 Gene

GeneHancer (GH) Regulatory Elements for PDZD11 Gene

Promoters and enhancers for PDZD11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI070288 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.2 227 2.6 ATF1 ARID4B SIN3A ETS1 POLR2B GLIS2 ELK1 KLF7 RUNX3 SP3 KIF4A PDZD11 MED12 NONO IGBP1 P2RY4 ARR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDZD11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDZD11 gene promoter:

Genomic Locations for PDZD11 Gene

Genomic Locations for PDZD11 Gene
chrX:70,286,361-70,290,514
(GRCh38/hg38)
Size:
4,154 bases
Orientation:
Minus strand
chrX:69,506,211-69,510,364
(GRCh37/hg19)

Genomic View for PDZD11 Gene

Genes around PDZD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDZD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDZD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDZD11 Gene

Proteins for PDZD11 Gene

  • Protein details for PDZD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBL8-PDZ11_HUMAN
    Recommended name:
    PDZ domain-containing protein 11
    Protein Accession:
    Q5EBL8
    Secondary Accessions:
    • D3DVU3
    • Q6UWE1
    • Q9P0Q1

    Protein attributes for PDZD11 Gene

    Size:
    140 amino acids
    Molecular mass:
    16131 Da
    Quaternary structure:
    • Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A.

    Alternative splice isoforms for PDZD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDZD11 Gene

Post-translational modifications for PDZD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDZD11 Gene

No data available for DME Specific Peptides for PDZD11 Gene

Domains & Families for PDZD11 Gene

Gene Families for PDZD11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDZD11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDZD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDZD11: view

No data available for UniProtKB/Swiss-Prot for PDZD11 Gene

Function for PDZD11 Gene

Gene Ontology (GO) - Molecular Function for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16051599
genes like me logo Genes that share ontologies with PDZD11: view
genes like me logo Genes that share phenotypes with PDZD11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDZD11 Gene

Localization for PDZD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDZD11 Gene

Isoform 2: Secreted.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDZD11 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IBA --
GO:0016323 basolateral plasma membrane IBA --
genes like me logo Genes that share ontologies with PDZD11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PDZD11 Gene

Pathways & Interactions for PDZD11 Gene

genes like me logo Genes that share pathways with PDZD11: view

Pathways by source for PDZD11 Gene

Gene Ontology (GO) - Biological Process for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006768 biotin metabolic process TAS --
GO:0007269 neurotransmitter secretion IBA --
GO:0015939 pantothenate metabolic process TAS --
GO:0019730 antimicrobial humoral response TAS --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with PDZD11: view

No data available for SIGNOR curated interactions for PDZD11 Gene

Drugs & Compounds for PDZD11 Gene

No Compound Related Data Available

Transcripts for PDZD11 Gene

Unigene Clusters for PDZD11 Gene

PDZ domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDZD11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - -
SP2:
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - -

Relevant External Links for PDZD11 Gene

GeneLoc Exon Structure for
PDZD11
ECgene alternative splicing isoforms for
PDZD11

Expression for PDZD11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDZD11 Gene

Protein differential expression in normal tissues from HIPED for PDZD11 Gene

This gene is overexpressed in Salivary gland (11.4) and Stomach (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDZD11 Gene



Protein tissue co-expression partners for PDZD11 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDZD11 Gene:

PDZD11

SOURCE GeneReport for Unigene cluster for PDZD11 Gene:

Hs.11042

mRNA Expression by UniProt/SwissProt for PDZD11 Gene:

Q5EBL8-PDZ11_HUMAN
Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for PDZD11 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with PDZD11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDZD11 Gene

Orthologs for PDZD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDZD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDZD11 33 34
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia PDZD11 33 34
  • 94.76 (n)
dog
(Canis familiaris)
Mammalia PDZD11 33 34
  • 94.05 (n)
rat
(Rattus norvegicus)
Mammalia Pdzd11 33
  • 93.33 (n)
mouse
(Mus musculus)
Mammalia Pdzd11 33 16 34
  • 92.62 (n)
oppossum
(Monodelphis domestica)
Mammalia PDZD11 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDZD11 33 34
  • 81.54 (n)
lizard
(Anolis carolinensis)
Reptilia PDZD11 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdzd11 33
  • 77.62 (n)
Str.2023 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19447 33
zebrafish
(Danio rerio)
Actinopterygii pdzd11 33 34
  • 73.57 (n)
Dr.15270 33
fruit fly
(Drosophila melanogaster)
Insecta veli 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-7 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for PDZD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDZD11 Gene

ENSEMBL:
Gene Tree for PDZD11 (if available)
TreeFam:
Gene Tree for PDZD11 (if available)

Paralogs for PDZD11 Gene

Paralogs for PDZD11 Gene

(8) SIMAP similar genes for PDZD11 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PDZD11 Gene

genes like me logo Genes that share paralogs with PDZD11: view

Variants for PDZD11 Gene

Sequence variations from dbSNP and Humsavar for PDZD11 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002108254 -- 70,289,897(-) T/C 5_prime_UTR_variant
rs1003676719 -- 70,288,970(-) C/A intron_variant
rs1004016687 -- 70,291,480(-) G/C upstream_transcript_variant
rs1004070386 -- 70,291,103(-) C/T upstream_transcript_variant
rs1004243191 -- 70,287,574(-) CCTCCC/CC intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDZD11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354

Variation tolerance for PDZD11 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDZD11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDZD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDZD11 Gene

Disorders for PDZD11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDZD11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
purulent acute otitis media
  • acute suppurative otitis media
middle ear disease
  • abnormality of the middle ear
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PDZD11

genes like me logo Genes that share disorders with PDZD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDZD11 Gene

Publications for PDZD11 Gene

  1. A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis. (PMID: 16051599) Stephenson SE … La Fontaine S (The Journal of biological chemistry 2005) 3 4 22 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PDZD11 Gene

Sources for PDZD11 Gene

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